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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 2
2005 1
2006 2
2011 1
2012 6
2013 7
2014 11
2015 10
2016 15
2017 20
2018 15
2019 19
2020 20
2021 29
2022 26
2023 31
2024 13

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208 results

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Page 1
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.
Marabelle A, Le DT, Ascierto PA, Di Giacomo AM, De Jesus-Acosta A, Delord JP, Geva R, Gottfried M, Penel N, Hansen AR, Piha-Paul SA, Doi T, Gao B, Chung HC, Lopez-Martin J, Bang YJ, Frommer RS, Shah M, Ghori R, Joe AK, Pruitt SK, Diaz LA Jr. Marabelle A, et al. J Clin Oncol. 2020 Jan 1;38(1):1-10. doi: 10.1200/JCO.19.02105. Epub 2019 Nov 4. J Clin Oncol. 2020. PMID: 31682550 Free PMC article. Clinical Trial.
Pembrolizumab, an anti-programmed death-1 monoclonal antibody, has antitumor activity against MSI-H/dMMR cancer. We report data from the phase II KEYNOTE-158 study of pembrolizumab in patients with previously treated, advanced noncolorectal MSI-H/dMMR cancer. ...RES …
Pembrolizumab, an anti-programmed death-1 monoclonal antibody, has antitumor activity against MSI-H/dMMR cancer. We report data from …
A disordered region controls cBAF activity via condensation and partner recruitment.
Patil A, Strom AR, Paulo JA, Collings CK, Ruff KM, Shinn MK, Sankar A, Cervantes KS, Wauer T, St Laurent JD, Xu G, Becker LA, Gygi SP, Pappu RV, Brangwynne CP, Kadoch C. Patil A, et al. Cell. 2023 Oct 26;186(22):4936-4955.e26. doi: 10.1016/j.cell.2023.08.032. Epub 2023 Oct 3. Cell. 2023. PMID: 37788668 Free article.
These features concentrate a specific cBAF protein-protein interaction network and are essential for chromatin localization and activity. Importantly, human disease-associated perturbations in ARID1B IDR sequence grammars disrupt cBAF function in cells. Together, these dat …
These features concentrate a specific cBAF protein-protein interaction network and are essential for chromatin localization and activity. Im …
TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer.
Yang B, Chen J, Li X, Zhang X, Hu L, Jiang S, Zhang Z, Teng Y. Yang B, et al. Cancer Lett. 2021 Sep 1;515:14-27. doi: 10.1016/j.canlet.2021.05.016. Epub 2021 May 25. Cancer Lett. 2021. PMID: 34044070
However, TNPO1, as an important karyopherin-beta family member, underlying functional roles in cancers remain largely unclear. In this study, under integrated gene-expression profiling screen of karyopherin-beta in gynecologic cancer, we identify TNPO1 as a pivotal …
However, TNPO1, as an important karyopherin-beta family member, underlying functional roles in cancers remain largely unclear. In thi …
Autism genes converge on asynchronous development of shared neuron classes.
Paulsen B, Velasco S, Kedaigle AJ, Pigoni M, Quadrato G, Deo AJ, Adiconis X, Uzquiano A, Sartore R, Yang SM, Simmons SK, Symvoulidis P, Kim K, Tsafou K, Podury A, Abbate C, Tucewicz A, Smith SN, Albanese A, Barrett L, Sanjana NE, Shi X, Chung K, Lage K, Boyden ES, Regev A, Levin JZ, Arlotta P. Paulsen B, et al. Nature. 2022 Feb;602(7896):268-273. doi: 10.1038/s41586-021-04358-6. Epub 2022 Feb 2. Nature. 2022. PMID: 35110736 Free PMC article.
Here we used organoid models of the human cerebral cortex to identify cell-type-specific developmental abnormalities that result from haploinsufficiency in three ASD risk genes-SUV420H1 (also known as KMT5B), ARID1B and CHD8-in multiple cell lines from different donors, us …
Here we used organoid models of the human cerebral cortex to identify cell-type-specific developmental abnormalities that result from haploi …
ARID1B: From the Garden of Eden to the Sahara.
Lin J. Lin J. J Thorac Cardiovasc Surg. 2018 Jun;155(6):e193-e194. doi: 10.1016/j.jtcvs.2018.01.058. Epub 2018 Feb 8. J Thorac Cardiovasc Surg. 2018. PMID: 29526365 Free article. No abstract available.
Targeting ARID1A-mutant colorectal cancer: depletion of ARID1B increases radiosensitivity and modulates DNA damage response.
Niedermaier B, Sak A, Zernickel E, Xu S, Groneberg M, Stuschke M. Niedermaier B, et al. Sci Rep. 2019 Dec 3;9(1):18207. doi: 10.1038/s41598-019-54757-z. Sci Rep. 2019. PMID: 31796878 Free PMC article.
Here, we investigated weather knockdown of ARID1B, one of two mutually exclusive subunits within the SWI/SNF complex, can sensitize colorectal cancer cell lines mutated in the other subunit, ARID1A, to ionizing radiation (IR). ARID1A-mutated colorectal cancer …
Here, we investigated weather knockdown of ARID1B, one of two mutually exclusive subunits within the SWI/SNF complex, can sensitize c …
DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis.
Sahm F, Schrimpf D, Stichel D, Jones DTW, Hielscher T, Schefzyk S, Okonechnikov K, Koelsche C, Reuss DE, Capper D, Sturm D, Wirsching HG, Berghoff AS, Baumgarten P, Kratz A, Huang K, Wefers AK, Hovestadt V, Sill M, Ellis HP, Kurian KM, Okuducu AF, Jungk C, Drueschler K, Schick M, Bewerunge-Hudler M, Mawrin C, Seiz-Rosenhagen M, Ketter R, Simon M, Westphal M, Lamszus K, Becker A, Koch A, Schittenhelm J, Rushing EJ, Collins VP, Brehmer S, Chavez L, Platten M, Hänggi D, Unterberg A, Paulus W, Wick W, Pfister SM, Mittelbronn M, Preusser M, Herold-Mende C, Weller M, von Deimling A. Sahm F, et al. Lancet Oncol. 2017 May;18(5):682-694. doi: 10.1016/S1470-2045(17)30155-9. Epub 2017 Mar 15. Lancet Oncol. 2017. PMID: 28314689 Free article.
We consider methylation-based tumour classification highly relevant for the future diagnosis and treatment of meningioma. FUNDING: German Cancer Aid, Else Kroner-Fresenius Foundation, and DKFZ/Heidelberg Institute of Personalized Oncology/Precision Oncology Program....
We consider methylation-based tumour classification highly relevant for the future diagnosis and treatment of meningioma. FUNDING: German …
Paraspeckles interact with SWI/SNF subunit ARID1B to regulate transcription and splicing.
Reddy D, Bhattacharya S, Levy M, Zhang Y, Gogol M, Li H, Florens L, Workman JL. Reddy D, et al. EMBO Rep. 2023 Jan 9;24(1):e55345. doi: 10.15252/embr.202255345. Epub 2022 Nov 10. EMBO Rep. 2023. PMID: 36354291 Free PMC article.
This is specifically mediated by the direct interaction of the long-non-coding RNA NEAT1 of the paraspeckles with ARID1B of the cBAF-type SWI/SNF complex. Strikingly, ARID1B depletion, in addition to resulting in loss of interaction with the SWI/SNF complex, decreas …
This is specifically mediated by the direct interaction of the long-non-coding RNA NEAT1 of the paraspeckles with ARID1B of the cBAF- …
Clinicopathological significance of ARID1B in breast invasive ductal carcinoma.
Shao F, Guo T, Chua PJ, Tang L, Thike AA, Tan PH, Bay BH, Baeg GH. Shao F, et al. Histopathology. 2015 Nov;67(5):709-18. doi: 10.1111/his.12701. Epub 2015 May 17. Histopathology. 2015. PMID: 25817822
METHODS AND RESULTS: Immunohistochemical analysis of ARID1B expression using breast cancer tissue microarrays containing 156 breast invasive ductal carcinoma patient samples and subsequent statistical data analysis based on ARID1B immunoreactivity score were …
METHODS AND RESULTS: Immunohistochemical analysis of ARID1B expression using breast cancer tissue microarrays containing 156 b …
Establishment and validation of preclinical models of SMARCA4-inactivated and ARID1A/ARID1B co-inactivated dedifferentiated endometrial carcinoma.
Wong NKY, Llaurado Fernandez M, Kommoss FKF, Praveen Kumar P, Kim H, Liu J, Zhang G, Coatham M, Lin YY, Haegert AM, Volik S, Le Bihan S, Collins CC, Fu Y, Postovit LM, von Deimling A, Wu R, Xue H, Wang Y, Köbel M, Carey MS, Lee CH. Wong NKY, et al. Gynecol Oncol. 2023 Sep;176:162-172. doi: 10.1016/j.ygyno.2023.07.016. Epub 2023 Aug 7. Gynecol Oncol. 2023. PMID: 37556934
OBJECTIVE: Dedifferentiated endometrial cancer (DDEC) is an uncommon and clinically highly aggressive subtype of endometrial cancer characterized by genomic inactivation of SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protein. ...The SMARCA4-deficienct DDEC mode …
OBJECTIVE: Dedifferentiated endometrial cancer (DDEC) is an uncommon and clinically highly aggressive subtype of endometrial cance …
208 results