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ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade.
Liu X, Cen X, Wu R, Chen Z, Xie Y, Wang F, Shan B, Zeng L, Zhou J, Xie B, Cai Y, Huang J, Liang Y, Wu Y, Zhang C, Wang D, Xia H. Liu X, et al. Nat Commun. 2023 Jul 10;14(1):4066. doi: 10.1038/s41467-023-39920-5. Nat Commun. 2023. PMID: 37429863 Free PMC article.
Using an ICB-insensitive tumor model, here we discover cisplatin enhances the anti-tumor effect of PD-L1 blockade and upregulates the expression of Ariadne RBR E3 ubiquitin-protein ligase 1 (ARIH1) in tumors. Arih1 overexpression promotes cytotoxic T cell infiltrati …
Using an ICB-insensitive tumor model, here we discover cisplatin enhances the anti-tumor effect of PD-L1 blockade and upregulates the expres …
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.
Wu Y, Zhang C, Liu X, He Z, Shan B, Zeng Q, Zhao Q, Zhu H, Liao H, Cen X, Xu X, Zhang M, Hou T, Wang Z, Yan H, Yang S, Sun Y, Chen Y, Wu R, Xie T, Chen W, Najafov A, Ying S, Xia H. Wu Y, et al. Nat Commun. 2021 Apr 20;12(1):2346. doi: 10.1038/s41467-021-22467-8. Nat Commun. 2021. PMID: 33879767 Free PMC article.
Overexpression of ARIH1 suppresses tumor growth and promotes cytotoxic T cell activation in wild-type, but not in immunocompromised mice, highlighting the role of ARIH1 in anti-tumor immunity. Moreover, combining EGFR inhibitor ES-072 with anti-CTLA4 immunotherapy r …
Overexpression of ARIH1 suppresses tumor growth and promotes cytotoxic T cell activation in wild-type, but not in immunocompromised m …
The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
Xiong TC, Wei MC, Li FX, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P, Zhong B, Zhang ZD, Lin D. Xiong TC, et al. Nat Commun. 2022 Oct 10;13(1):5973. doi: 10.1038/s41467-022-33671-5. Nat Commun. 2022. PMID: 36217001 Free PMC article.
Consistently, tamoxifen-treated ER-Cre;Arih1(fl/fl) mice and Lyz2-Cre; Arih1(fl/fl) mice are hypersensitive to HSV-1 infection compared with the controls. ...Mechanistically, HSV-1- or cytosolic DNA-induced oligomerization and activation of cGAS are potentiated by I …
Consistently, tamoxifen-treated ER-Cre;Arih1(fl/fl) mice and Lyz2-Cre; Arih1(fl/fl) mice are hypersensitive to HSV-1 infection …
The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.
Howley BV, Mohanty B, Dalton A, Grelet S, Karam J, Dincman T, Howe PH. Howley BV, et al. Oncogene. 2022 Mar;41(12):1679-1690. doi: 10.1038/s41388-022-02199-9. Epub 2022 Jan 31. Oncogene. 2022. PMID: 35102251 Free PMC article.
ARIH1 silencing in breast cancer cells significantly attenuated cancer cell stemness in vitro and tumor formation in vivo. Finally, we utilized miniTurboID proximity labeling to identify novel ARIH1 interactors that may contribute to ARIH1's fun …
ARIH1 silencing in breast cancer cells significantly attenuated cancer cell stemness in vitro and tumor formation in vi …
Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells.
Villa E, Proïcs E, Rubio-Patiño C, Obba S, Zunino B, Bossowski JP, Rozier RM, Chiche J, Mondragón L, Riley JS, Marchetti S, Verhoeyen E, Tait SWG, Ricci JE. Villa E, et al. Cell Rep. 2017 Sep 19;20(12):2846-2859. doi: 10.1016/j.celrep.2017.08.087. Cell Rep. 2017. PMID: 28930681 Free article.
Here, we identified an E3 ubiquitin ligase (ARIH1/HHARI) that triggers mitophagy in cancer cells in a PINK1-dependent manner. ...Importantly, ARIH1 is widely expressed in cancer cells, notably in breast and lung adenocarcinomas; ARIH1 expression …
Here, we identified an E3 ubiquitin ligase (ARIH1/HHARI) that triggers mitophagy in cancer cells in a PINK1-dependent manner. …
RBR E3 ubiquitin ligases in tumorigenesis.
Wang P, Dai X, Jiang W, Li Y, Wei W. Wang P, et al. Semin Cancer Biol. 2020 Dec;67(Pt 2):131-144. doi: 10.1016/j.semcancer.2020.05.002. Epub 2020 May 19. Semin Cancer Biol. 2020. PMID: 32442483 Review.
Emerging evidence has demonstrated that RBR E3 ligases play essential roles in neurodegenerative diseases, infection, inflammation and cancer. Accumulated evidence has revealed that RBR E3 ligases exert their biological functions in various types of cancers by modul …
Emerging evidence has demonstrated that RBR E3 ligases play essential roles in neurodegenerative diseases, infection, inflammation and ca …
A novel ARIH1::BRAF fusion in a glioma.
Xu E, Stone SL, Zhong Y, Golenberg N, Qiu L, Abdullaev Z, Aldape K, Bagley L, Halpern CH, Amankulor N, Nasrallah MP. Xu E, et al. J Neuropathol Exp Neurol. 2023 Oct 20;82(11):966-969. doi: 10.1093/jnen/nlad074. J Neuropathol Exp Neurol. 2023. PMID: 37742132 Free PMC article. No abstract available.
The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
von Stechow L, Typas D, Carreras Puigvert J, Oort L, Siddappa R, Pines A, Vrieling H, van de Water B, Mullenders LH, Danen EH. von Stechow L, et al. Mol Cell Biol. 2015 Apr;35(7):1254-68. doi: 10.1128/MCB.01152-14. Epub 2015 Jan 26. Mol Cell Biol. 2015. PMID: 25624349 Free PMC article.
Silencing ARIH1 sensitized ES and cancer cells to genotoxic compounds and ionizing radiation, irrespective of their p53 or caspase-3 status. ...These findings identify ARIH1 as a potent mediator of DNA damage-induced translation arrest that protects stem and …
Silencing ARIH1 sensitized ES and cancer cells to genotoxic compounds and ionizing radiation, irrespective of their p53 or cas …
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex.
Nguyen DM, Rath DH, Devost D, Pétrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hébert TE, Privé GG. Nguyen DM, et al. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2315018121. doi: 10.1073/pnas.2315018121. Epub 2024 Apr 16. Proc Natl Acad Sci U S A. 2024. PMID: 38625940
The cryo-EM structure of a 5:5:5 KCTD5/CUL3(NTD)/Gbeta(1)gamma(2) assembly reveals a highly dynamic complex with rotations of over 60 between the KCTD5(BTB)/CUL3(NTD) and KCTD5(CTD)/Gbetagamma moieties of the structure. CRL3(KCTD5) engages the E3 ligase ARIH1 to ubiquityla …
The cryo-EM structure of a 5:5:5 KCTD5/CUL3(NTD)/Gbeta(1)gamma(2) assembly reveals a highly dynamic complex with rotations of over 60 betwee …
Age-related mutations and chronic myelomonocytic leukemia.
Mason CC, Khorashad JS, Tantravahi SK, Kelley TW, Zabriskie MS, Yan D, Pomicter AD, Reynolds KR, Eiring AM, Kronenberg Z, Sherman RL, Tyner JW, Dalley BK, Dao KH, Yandell M, Druker BJ, Gotlib J, O'Hare T, Deininger MW. Mason CC, et al. Leukemia. 2016 Apr;30(4):906-13. doi: 10.1038/leu.2015.337. Epub 2015 Dec 9. Leukemia. 2016. PMID: 26648538 Free PMC article.
Genes mutated in 10% of patients were SRSF2, TET2, ASXL1, RUNX1, SETBP1, KRAS, EZH2, CBL and NRAS, as well as the novel CMML genes FAT4, ARIH1, DNAH2 and CSMD1. Most CMML patients (71%) had mutations in 2 ARCH genes and 52% had 7 mutations overall. ...
Genes mutated in 10% of patients were SRSF2, TET2, ASXL1, RUNX1, SETBP1, KRAS, EZH2, CBL and NRAS, as well as the novel CMML genes FAT4, …
21 results