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The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
Jia J, Absmeier E, Holton N, Pietrzyk-Brzezinska AJ, Hackert P, Bohnsack KE, Bohnsack MT, Wahl MC. Jia J, et al. Nat Commun. 2020 Nov 2;11(1):5535. doi: 10.1038/s41467-020-19221-x. Nat Commun. 2020. PMID: 33139697 Free PMC article.
ASCC2-ASCC3 interfaces are evolutionarily highly conserved and comprise a large number of residues affected by somatic cancer mutations. We quantified contributions of protein regions to the ASCC2-ASCC3 interaction, observing that changes found in cancers …
ASCC2-ASCC3 interfaces are evolutionarily highly conserved and comprise a large number of residues affected by somatic cancer …
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinović V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N. Tsao N, et al. Mol Cell. 2021 Oct 21;81(20):4228-4242.e8. doi: 10.1016/j.molcel.2021.09.024. Mol Cell. 2021. PMID: 34686315 Free PMC article.
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N. Brickner JR, et al. Nature. 2017 Nov 16;551(7680):389-393. doi: 10.1038/nature24484. Epub 2017 Nov 8. Nature. 2017. PMID: 29144457 Free PMC article.
Understanding the upstream signalling events that mediate recognition and repair of DNA alkylation damage is particularly important, since alkylation chemotherapy is one of the most widely used systemic modalities for cancer treatment and because environmental chemicals ma …
Understanding the upstream signalling events that mediate recognition and repair of DNA alkylation damage is particularly important, since a …
The ASC-1 Complex Disassembles Collided Ribosomes.
Juszkiewicz S, Speldewinde SH, Wan L, Svejstrup JQ, Hegde RS. Juszkiewicz S, et al. Mol Cell. 2020 Aug 20;79(4):603-614.e8. doi: 10.1016/j.molcel.2020.06.006. Epub 2020 Jun 23. Mol Cell. 2020. PMID: 32579943 Free PMC article.
Whole-genome characterization of myoepithelial carcinomas of the soft tissue.
Cyrta J, Rosiene J, Bareja R, Kudman S, Al Zoughbi W, Motanagh S, Wilkes DC, Eng K, Zhang T, Sticca E, Mathew S, Rubin MA, Sboner A, Elemento O, Rubin BP, Imielinski M, Mosquera JM. Cyrta J, et al. Cold Spring Harb Mol Case Stud. 2022 Dec 28;8(7):a006227. doi: 10.1101/mcs.a006227. Print 2022 Dec. Cold Spring Harb Mol Case Stud. 2022. PMID: 36577525 Free PMC article.
By WES and WGS, tumors from both patients displayed low tumor mutation burdens, and no targetable alterations in cancer genes were detected. P2's tumor harbored an EWSR1::KLF15 rearrangement, whereas the tumor from P1 showed a novel ASCC2::GGNBP2 fusion. ...Furtherm …
By WES and WGS, tumors from both patients displayed low tumor mutation burdens, and no targetable alterations in cancer genes were de …
Cellular response to small molecules that selectively stall protein synthesis by the ribosome.
Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD. Liaud N, et al. PLoS Genet. 2019 Mar 15;15(3):e1008057. doi: 10.1371/journal.pgen.1008057. eCollection 2019 Mar. PLoS Genet. 2019. PMID: 30875366 Free PMC article.
The two most potent genetic modifiers of cell fitness in the presence of PF8503, the ubiquitin binding protein ASCC2 and helicase ASCC3, bind to the ribosome and protect cells from toxic effects of high concentrations of the compound. ...In genetic interaction experiments, …
The two most potent genetic modifiers of cell fitness in the presence of PF8503, the ubiquitin binding protein ASCC2 and helicase ASC …
Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac.
Sudha T, Bharali DJ, Yalcin M, Darwish NH, Coskun MD, Keating KA, Lin HY, Davis PJ, Mousa SA. Sudha T, et al. Nanomedicine (Lond). 2017 Feb;12(3):195-205. doi: 10.2217/nnm-2016-0315. Epub 2017 Jan 19. Nanomedicine (Lond). 2017. PMID: 28102776
AIM: Nano-diamino-tetrac (NDAT) targets a receptor on integrin alphavbeta3; alphavbeta3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. ...CONCLUSION: NDAT markedly enhances cisplatin delivery to urinary b …
AIM: Nano-diamino-tetrac (NDAT) targets a receptor on integrin alphavbeta3; alphavbeta3 is generously expressed by cancer cells and d …