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Year Number of Results
2008 1
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2011 2
2012 5
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2017 10
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2021 14
2022 17
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132 results

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Page 1
Ferroptosis is a type of autophagy-dependent cell death.
Zhou B, Liu J, Kang R, Klionsky DJ, Kroemer G, Tang D. Zhou B, et al. Semin Cancer Biol. 2020 Nov;66:89-100. doi: 10.1016/j.semcancer.2019.03.002. Epub 2019 Mar 14. Semin Cancer Biol. 2020. PMID: 30880243 Review.
Ferroptosis was originally defined in 2012 as an iron-dependent form of cancer cell death different from apoptosis, necrosis, and autophagy. However, this latter assumption came into question because, in response to ferroptosis activators (e.g., erastin and RSL3), autophag …
Ferroptosis was originally defined in 2012 as an iron-dependent form of cancer cell death different from apoptosis, necrosis, and aut …
OBHS impairs the viability of breast cancer via decreasing ERalpha and Atg13.
Zhou J, Shen R, Zhou HB, Huang J. Zhou J, et al. Biochem Biophys Res Commun. 2021 Oct 8;573:69-75. doi: 10.1016/j.bbrc.2021.08.013. Epub 2021 Aug 8. Biochem Biophys Res Commun. 2021. PMID: 34388457
Breast cancer (BRCA) is one of the most threatening cancer types, especially among the female population. 70% of breast cancer are estrogen receptor alpha (ERalpha) positive and endocrine therapy is effective to decrease breast cancer risk. ...We found …
Breast cancer (BRCA) is one of the most threatening cancer types, especially among the female population. 70% of breast can …
Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2.5-induced pulmonary fibrosis.
Ning J, Pei Z, Wang M, Hu H, Chen M, Liu Q, Wu M, Yang P, Geng Z, Zheng J, Du Z, Hu W, Wang Q, Pang Y, Bao L, Niu Y, Leng S, Zhang R. Ning J, et al. J Hazard Mater. 2023 Sep 5;457:131791. doi: 10.1016/j.jhazmat.2023.131791. Epub 2023 Jun 7. J Hazard Mater. 2023. PMID: 37295326
PM2.5-downregulated ALKBH5 protein expression promotes m6A modification of Atg13 mRNA at site 767 in lung epithelial cells. Atg13-mediated ULK complex positively regulated autophagy and inflammation in epithelial cells with PM2.5 treatment. ...Thus, our results high …
PM2.5-downregulated ALKBH5 protein expression promotes m6A modification of Atg13 mRNA at site 767 in lung epithelial cells. Atg13 …
Copper metabolism in cell death and autophagy.
Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X. Xue Q, et al. Autophagy. 2023 Aug;19(8):2175-2195. doi: 10.1080/15548627.2023.2200554. Epub 2023 Apr 16. Autophagy. 2023. PMID: 37055935 Free PMC article. Review.
Pathologically, impaired copper metabolism due to environmental or genetic causes is implicated in a variety of human diseases, such as rare Wilson disease and common cancers. Therapeutically, copper-based compounds are potential chemotherapeutic agents that can be used al …
Pathologically, impaired copper metabolism due to environmental or genetic causes is implicated in a variety of human diseases, such as rare …
IRF1 Inhibits Autophagy-Mediated Proliferation of Colorectal Cancer via Targeting ATG13.
Yuan L, Zhang X, Cheng K, Li L, Guo Z, Zeng L. Yuan L, et al. Cancer Invest. 2022 Jan;40(1):35-45. doi: 10.1080/07357907.2021.1961265. Epub 2021 Aug 17. Cancer Invest. 2022. PMID: 34313498
Under starvation conditions, IRF1 enhanced apoptosis and reduced autophagic flux. ATG13, an important factor of autophagy complex, was confirmed as a target of IRF1. These findings indicated that IRF1 function as a tumor suppressor in CRC and inhibit autophagy through A …
Under starvation conditions, IRF1 enhanced apoptosis and reduced autophagic flux. ATG13, an important factor of autophagy complex, wa …
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.
Yang Y, Zhu Y, Zhou S, Tang P, Xu R, Zhang Y, Wei D, Wen J, Thorne RF, Zhang XD, Guan JL, Liu L, Wu M, Chen S. Yang Y, et al. EMBO J. 2022 Jul 18;41(14):e109777. doi: 10.15252/embj.2021109777. Epub 2022 Jun 7. EMBO J. 2022. PMID: 35670107 Free PMC article.
Autophagy represents a fundamental mechanism for maintaining cell survival and tissue homeostasis in response to physiological and pathological stress. Autophagy initiation converges on the FIP200-ATG13-ULK1 complex wherein the serine/threonine kinase ULK1 plays a central …
Autophagy represents a fundamental mechanism for maintaining cell survival and tissue homeostasis in response to physiological and pathologi …
Brucea javanica Oil Emulsion Promotes Autophagy in Ovarian Cancer Cells Through the miR-8485/LAMTOR3/mTOR/ATG13 Signaling Axis.
Wang Y, Chen B, Xiao M, Wang X, Peng Y. Wang Y, et al. Front Pharmacol. 2022 Jul 25;13:935155. doi: 10.3389/fphar.2022.935155. eCollection 2022. Front Pharmacol. 2022. PMID: 35959437 Free PMC article.
Background: Ovarian cancer is a common malignant tumor of the female reproductive tract, with the highest mortality rate. ...The results of qRT-PCR and Western blot showed that BJOE and overexpressed miR-8485 downregulated the expression of LAMTOR3 and mTOR and up-regulate …
Background: Ovarian cancer is a common malignant tumor of the female reproductive tract, with the highest mortality rate. ...The resu …
The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.
Karabi Z, Moradian F, Kheirabadi M. Karabi Z, et al. Cell Biochem Biophys. 2022 Dec;80(4):795-806. doi: 10.1007/s12013-022-01097-x. Epub 2022 Sep 28. Cell Biochem Biophys. 2022. PMID: 36169801
Recently, the study of autophagy and its mechanism on the cancer cell growth process has received much attention. lactoferrin (Lf) is a glycoprotein with various biological activities, including antibacterial, antiviral, anti-cancer, etc. In the present study, the e …
Recently, the study of autophagy and its mechanism on the cancer cell growth process has received much attention. lactoferrin (Lf) is …
Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy.
Cross J, Durgan J, McEwan DG, Tayler M, Ryan KM, Florey O. Cross J, et al. J Cell Biol. 2023 Dec 4;222(12):e202303078. doi: 10.1083/jcb.202303078. Epub 2023 Oct 5. J Cell Biol. 2023. PMID: 37796195 Free PMC article.
Following damage, ATG8s are rapidly and directly conjugated onto lysosome membranes, independently of ATG13/WIPI2, lipidating to PS (and PE), a molecular hallmark of CASM. ...
Following damage, ATG8s are rapidly and directly conjugated onto lysosome membranes, independently of ATG13/WIPI2, lipidating to PS ( …
Novel exosomal circEGFR facilitates triple negative breast cancer autophagy via promoting TFEB nuclear trafficking and modulating miR-224-5p/ATG13/ULK1 feedback loop.
Song H, Zhao Z, Ma L, Zhao W, Hu Y, Song Y. Song H, et al. Oncogene. 2024 Mar;43(11):821-836. doi: 10.1038/s41388-024-02950-4. Epub 2024 Jan 27. Oncogene. 2024. PMID: 38280941 Free PMC article.
Triple-negative breast cancer (TNBC) cells are in a more hypoxic and starved state than non-TNBC cells, which makes TNBC cells always maintain high autophagy levels. ...Meanwhile, circEGFR acted as ceRNA by directly binding to miR-224-5p and inhibited the expression of miR …
Triple-negative breast cancer (TNBC) cells are in a more hypoxic and starved state than non-TNBC cells, which makes TNBC cells always …
132 results