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Year Number of Results
2004 1
2008 1
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2011 2
2012 1
2013 4
2014 6
2015 4
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2017 16
2018 17
2019 24
2020 15
2021 20
2022 20
2023 19
2024 8

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147 results

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Page 1
Targeting Atg4B for cancer therapy: Chemical mediators.
Yang G, Li Y, Zhao Y, Ouyang L, Chen Y, Liu B, Liu J. Yang G, et al. Eur J Med Chem. 2021 Jan 1;209:112917. doi: 10.1016/j.ejmech.2020.112917. Epub 2020 Oct 11. Eur J Med Chem. 2021. PMID: 33077263 Review.
Atg4, a pivotal macroautophagy/autophagy-related cysteine protein family, which regulate autophagy through either cleaving Atg8 homologs for its further lipidation or delipidating Atg8 homologs from the autophagosome. There are four homologs, Atg4A, Atg4B, Atg4C, and Atg4D …
Atg4, a pivotal macroautophagy/autophagy-related cysteine protein family, which regulate autophagy through either cleaving Atg8 homologs for …
Ferroptosis is a type of autophagy-dependent cell death.
Zhou B, Liu J, Kang R, Klionsky DJ, Kroemer G, Tang D. Zhou B, et al. Semin Cancer Biol. 2020 Nov;66:89-100. doi: 10.1016/j.semcancer.2019.03.002. Epub 2019 Mar 14. Semin Cancer Biol. 2020. PMID: 30880243 Review.
Ferroptosis was originally defined in 2012 as an iron-dependent form of cancer cell death different from apoptosis, necrosis, and autophagy. However, this latter assumption came into question because, in response to ferroptosis activators (e.g., erastin and RSL3), autophag …
Ferroptosis was originally defined in 2012 as an iron-dependent form of cancer cell death different from apoptosis, necrosis, and aut …
ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer.
Hu WH, Liu TT, Liu PF, Morgan P, Lin IL, Tsai WL, Cheng YY, Hsieh AT, Hu TH, Shu CW. Hu WH, et al. Cancer Cell Int. 2023 Apr 10;23(1):63. doi: 10.1186/s12935-023-02909-7. Cancer Cell Int. 2023. PMID: 37038218 Free PMC article.
BACKGROUND: Autophagy related protease 4B (ATG4B) is a protease required for autophagy processing, which is strongly implicated in cancer progression. Phosphorylation of ATG4B is crucial for activation of its protease activity. However, little is known about …
BACKGROUND: Autophagy related protease 4B (ATG4B) is a protease required for autophagy processing, which is strongly implicated in …
YY1 is regulated by ALKBH5-mediated m6A modification and promotes autophagy and cancer progression through targeting ATG4B.
Wang S, Nie J, Xu K, Liu Y, Tong W, Li A, Zuo W, Liu Z, Yang F. Wang S, et al. Aging (Albany NY). 2023 Sep 18;15(18):9590-9613. doi: 10.18632/aging.205037. Epub 2023 Sep 18. Aging (Albany NY). 2023. PMID: 37724907 Free PMC article.
Gain- and loss-of-function assays were employed in the scrutiny of the biological effects of the ALKBH5/YY1/ATG4B axis on cancer cell proliferation and invasion abilities in vitro. Per the findings, YY1 was identified as a crucial transcriptional activator of can …
Gain- and loss-of-function assays were employed in the scrutiny of the biological effects of the ALKBH5/YY1/ATG4B axis on cancer …
ATG4B promotes colorectal cancer growth independent of autophagic flux.
Liu PF, Leung CM, Chang YH, Cheng JS, Chen JJ, Weng CJ, Tsai KW, Hsu CJ, Liu YC, Hsu PC, Pan HW, Shu CW. Liu PF, et al. Autophagy. 2014 Aug;10(8):1454-65. doi: 10.4161/auto.29556. Epub 2014 Jun 12. Autophagy. 2014. PMID: 24991826 Free PMC article.
In this study, we found that ATG4B knockdown induced autophagic flux and reduced CCND1 expression to inhibit G 1/S phase transition of cell cycle in colorectal cancer cell lines, indicating functional dominance of ATG4B on autophagy inhibition and tumor proli …
In this study, we found that ATG4B knockdown induced autophagic flux and reduced CCND1 expression to inhibit G 1/S phase transition o …
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B.
Zhang Y, Ding Y, Li M, Yuan J, Yu Y, Bi X, Hong H, Ye J, Liu P. Zhang Y, et al. Acta Pharm Sin B. 2022 May;12(5):2374-2390. doi: 10.1016/j.apsb.2021.09.020. Epub 2021 Sep 25. Acta Pharm Sin B. 2022. PMID: 35646533 Free PMC article.
Mechanistically, miR-34c-5p suppressed autophagic flux in cardiomyocytes, which contributed to the development of hypertrophy. Furthermore, the autophagy-related gene 4B (ATG4B) was identified as a direct target of miR-34c-5p, and miR-34c-5p was certified to interact with …
Mechanistically, miR-34c-5p suppressed autophagic flux in cardiomyocytes, which contributed to the development of hypertrophy. Furthermore, …
Targeting ATG4 in Cancer Therapy.
Fu Y, Huang Z, Hong L, Lu JH, Feng D, Yin XM, Li M. Fu Y, et al. Cancers (Basel). 2019 May 10;11(5):649. doi: 10.3390/cancers11050649. Cancers (Basel). 2019. PMID: 31083460 Free PMC article. Review.
In this review, we address the central roles of ATG4B in the autophagy machinery and in targeted cancer therapy. Specifically, we discuss how pharmacologically inhibiting ATG4B can benefit cancer therapies....
In this review, we address the central roles of ATG4B in the autophagy machinery and in targeted cancer therapy. Specifically, …
A Novel Protein Encoded by Exosomal CircATG4B Induces Oxaliplatin Resistance in Colorectal Cancer by Promoting Autophagy.
Pan Z, Zheng J, Zhang J, Lin J, Lai J, Lyu Z, Feng H, Wang J, Wu D, Li Y. Pan Z, et al. Adv Sci (Weinh). 2022 Dec;9(35):e2204513. doi: 10.1002/advs.202204513. Epub 2022 Oct 26. Adv Sci (Weinh). 2022. PMID: 36285810 Free PMC article.
Oxaliplatin is commonly used in chemotherapeutic regimens for colorectal cancer (CRC) after surgical resection. However, acquired chemoresistance seriously affects the curative effect in CRC patients, and the mechanism is still unclear. ...Next, circATG4B-222aa is found to …
Oxaliplatin is commonly used in chemotherapeutic regimens for colorectal cancer (CRC) after surgical resection. However, acquired che …
New Anti-Cancer Strategy to Suppress Colorectal Cancer Growth Through Inhibition of ATG4B and Lysosome Function.
Fu Y, Gu Q, Luo L, Xu J, Luo Y, Xia F, Han F, Hong L, Yin XM, Huang Z, Li M. Fu Y, et al. Cancers (Basel). 2020 Jun 10;12(6):1523. doi: 10.3390/cancers12061523. Cancers (Basel). 2020. PMID: 32532053 Free PMC article.
Autophagy inhibition has been proposed to be a potential therapeutic strategy for cancer, however, few autophagy inhibitors have been developed. Recent studies have indicated that lysosome and autophagy related 4B cysteine peptidase (ATG4B) are two promising targets …
Autophagy inhibition has been proposed to be a potential therapeutic strategy for cancer, however, few autophagy inhibitors have been …
Identification of breast cancer cell subtypes sensitive to ATG4B inhibition.
Bortnik S, Choutka C, Horlings HM, Leung S, Baker JH, Lebovitz C, Dragowska WH, Go NE, Bally MB, Minchinton AI, Gelmon KA, Gorski SM. Bortnik S, et al. Oncotarget. 2016 Oct 11;7(41):66970-66988. doi: 10.18632/oncotarget.11408. Oncotarget. 2016. PMID: 27556700 Free PMC article.
We examined a panel of breast cancer cell lines, xenograft tumors, and breast cancer patient specimens for the protein expression of ATG4B, and found a positive association between HER2 and ATG4B protein expression. ...Together these results demonstrat …
We examined a panel of breast cancer cell lines, xenograft tumors, and breast cancer patient specimens for the protein express …
147 results