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2023 2
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Construction of molecular subgroups of ulcerative colitis.
Ma JL, Zhang HJ, Zhang CF, Zhang YY, Wang GM. Ma JL, et al. Eur Rev Med Pharmacol Sci. 2023 Oct;27(19):9333-9345. doi: 10.26355/eurrev_202310_33961. Eur Rev Med Pharmacol Sci. 2023. PMID: 37843347 Free article.
RESULTS: Patients with UC were classified into two subgroups. Genes specific to subgroup I included IL21R, ATP8B2, and PLEKHO1. Severe disease tended to be associated with immune cell infiltration; anti-tumor necrosis factor (TNF)-alpha antibodies and ustekinumab may have …
RESULTS: Patients with UC were classified into two subgroups. Genes specific to subgroup I included IL21R, ATP8B2, and PLEKHO1. Sever …
Establishment of a Macrophage Phenotypic Switch Related Prognostic Signature in Patients With Pancreatic Cancer.
Li MX, Wang HY, Yuan CH, Ma ZL, Jiang B, Li L, Zhang L, Xiu DR. Li MX, et al. Front Oncol. 2021 Mar 3;11:619517. doi: 10.3389/fonc.2021.619517. eCollection 2021. Front Oncol. 2021. PMID: 33747931 Free PMC article.
We aimed to build a prognostic signature by exploring the expression pattern of macrophage phenotypic switch related genes (MRGs) in the Cancer Genome Atlas (TCGA)-pancreatic adenocarcinoma (PAAD), Genotype-Tissue Expression (GTEx)-Pancreas, and Gene Expression Omnibus (GE …
We aimed to build a prognostic signature by exploring the expression pattern of macrophage phenotypic switch related genes (MRGs) in the …
LDHA is a prognostic biomarker on the immune response in pancreatic adenocarcinoma and associated with m6A modification.
Tan Z, Liu J, Xu J, Zhang B, Yu X, Wang W, Liang C. Tan Z, et al. J Cancer Res Clin Oncol. 2023 Jul;149(8):4853-4865. doi: 10.1007/s00432-022-04400-8. Epub 2022 Oct 21. J Cancer Res Clin Oncol. 2023. PMID: 36269388
METHODS: In the present study, m(6)A-related metabolic genes were obtained from The Cancer Genome Atlas (TCGA) pancreatic adenocarcinoma dataset and subjected to coexpression analysis. ...A nomogram including clinical features and the risk score based on the expression of …
METHODS: In the present study, m(6)A-related metabolic genes were obtained from The Cancer Genome Atlas (TCGA) pancreatic adenocarcin …
A trans-eQTL network regulates osteoclast multinucleation and bone mass.
Pereira M, Ko JH, Logan J, Protheroe H, Kim KB, Tan ALM, Croucher PI, Park KS, Rotival M, Petretto E, Bassett JD, Williams GR, Behmoaras J. Pereira M, et al. Elife. 2020 Jun 19;9:e55549. doi: 10.7554/eLife.55549. Elife. 2020. PMID: 32553114 Free PMC article.
We found that the network hub gene Bcat1 and seven other co-regulated MMnet genes out of 13, regulate bone function. Specifically, global (Pik3cb(-/-), Atp8b2(+/-), Igsf8(-/-), Eml1(-/-), Appl2(-/-), Deptor(-/-)) and myeloid-specific Slc40a1 knockout mice displayed abnorma …
We found that the network hub gene Bcat1 and seven other co-regulated MMnet genes out of 13, regulate bone function. Specifically, global (P …
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, Ma RC, Okada Y, Iwata M, Hosoe J, Shojima N, Iwasaki M, Fujita H, Suzuki K, Danesh J, Jørgensen T, Jørgensen ME, Witte DR, Brandslund I, Christensen C, Hansen T, Mercader JM, Flannick J, Moreno-Macías H, Burtt NP, Zhang R, Kim YJ, Zheng W, Singh JR, Tam CH, Hirose H, Maegawa H, Ito C, Kaku K, Watada H, Tanaka Y, Tobe K, Kawamori R, Kubo M, Cho YS, Chan JC, Sanghera D, Frossard P, Park KS, Shu XO, Kim BJ, Florez JC, Tusié-Luna T, Jia W, Tai ES, Pedersen O, Saleheen D, Maeda S, Kadowaki T. Imamura M, et al. Nat Commun. 2016 Jan 28;7:10531. doi: 10.1038/ncomms10531. Nat Commun. 2016. PMID: 26818947 Free PMC article.
Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near …
Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide …