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Year Number of Results
1998 2
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2007 3
2008 1
2009 1
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2014 6
2015 1
2016 3
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67 results

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Page 1
ATXN3 promotes prostate cancer progression by stabilizing YAP.
Wu L, Ou Z, Liu P, Zhao C, Tong S, Wang R, Li Y, Yuan J, Chen M, Fan B, Zu X, Wang Y, Tang J. Wu L, et al. Cell Commun Signal. 2023 Jun 22;21(1):152. doi: 10.1186/s12964-023-01073-9. Cell Commun Signal. 2023. PMID: 37349820 Free PMC article.
BACKGROUND: Prostate cancer (PC) is the most common neoplasm and is the second leading cause of cancer-related deaths in men worldwide. ...Further mechanistic study revealed that the Josephin domain of ATXN3 interacted with the WW domain of YAP. ATXN3 …
BACKGROUND: Prostate cancer (PC) is the most common neoplasm and is the second leading cause of cancer-related deaths in men w …
ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4.
Zou H, Chen H, Zhou Z, Wan Y, Liu Z. Zou H, et al. Cancer Lett. 2019 Dec 28;467:19-28. doi: 10.1016/j.canlet.2019.09.012. Epub 2019 Sep 26. Cancer Lett. 2019. PMID: 31563563
High ATXN3/KLF4 expression was associated with a poor prognosis in breast cancer patients. Collectively, we identified ATXN3 as a novel deubiquitinating enzyme of KLF4, providing a new explanation for breast cancer metastasis, and proposed ATXN3 …
High ATXN3/KLF4 expression was associated with a poor prognosis in breast cancer patients. Collectively, we identified ATXN …
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H. Zhu R, et al. Nat Commun. 2019 Jun 28;10(1):2863. doi: 10.1038/s41467-019-10739-3. Nat Commun. 2019. PMID: 31253779 Free PMC article.
Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. ...Accordingly, expression levels of TSPAN8, PTCH1, SHH, and ATXN3 are positively correlated in human breast cancer specimens, and high TSPAN8 and ATXN3 ex …
Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. ...Accordingly, expression levels of …
CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion.
Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, Zhou Y, Gao Q, Zhang L, Yan M, Sun Z, Fang D. Wang S, et al. J Clin Invest. 2023 Dec 1;133(23):e167728. doi: 10.1172/JCI167728. J Clin Invest. 2023. PMID: 38038129 Free PMC article.
Herein, we describe a CRISPR-based screening platform and identified ATXN3 as a positive regulator for PD-L1 transcription. TCGA database analysis revealed a positive correlation between ATXN3 and CD274 in more than 80% of human cancers. ...Targeted deletion …
Herein, we describe a CRISPR-based screening platform and identified ATXN3 as a positive regulator for PD-L1 transcription. TCGA data …
Involvement of Ataxin-3 (ATXN3) in the malignant progression of pancreatic cancer via deubiquitinating HDAC6.
Wu X, Zhang X, Liu P, Wang Y. Wu X, et al. Pancreatology. 2023 Sep;23(6):630-641. doi: 10.1016/j.pan.2023.06.011. Epub 2023 Jul 7. Pancreatology. 2023. PMID: 37460341
The underlying mechanism of ATXN3 was determined by knockdown of HDAC6 in ATXN3-upregulated pancreatic cancer cells. The function of ATXN3 in vivo was verified through xenograft assay. RESULTS: High expression of ATXN3 was found in pancreatic …
The underlying mechanism of ATXN3 was determined by knockdown of HDAC6 in ATXN3-upregulated pancreatic cancer cells. Th …
MicroRNA-25/ATXN3 interaction regulates human colon cancer cell growth and migration.
Li D, Zhang T, Lai J, Zhang J, Wang T, Ling Y, He S, Hu Z. Li D, et al. Mol Med Rep. 2019 May;19(5):4213-4221. doi: 10.3892/mmr.2019.10090. Epub 2019 Mar 27. Mol Med Rep. 2019. PMID: 30942397 Free PMC article.
Downregulation of miR-25 induced apoptosis of colon cancer cells via increased expression ATXN3. Small interfering-ATXN3 inhibited the anti-cancer effects of miR-25 downregulation in colon cancer. Collectively, the present results demonstrated t …
Downregulation of miR-25 induced apoptosis of colon cancer cells via increased expression ATXN3. Small interfering-ATXN3 …
ATXN3 deubiquitinates YAP1 to promote tumor growth.
Wang S, Liu K, Han X, Cheng Y, Zhao E, Brat DJ, Sun Z, Fang D. Wang S, et al. Am J Cancer Res. 2023 Sep 15;13(9):4222-4234. eCollection 2023. Am J Cancer Res. 2023. PMID: 37818078 Free PMC article.
The ubiquitin-specific peptidase Ataxin-3 (ATXN3) has emerged as a potential oncogene in a variety of human cancers. ...Consequently, ATXN3 suppression resulted in reduced cancer cell growth and migration, which can also be largely rescued by YAP1 reco …
The ubiquitin-specific peptidase Ataxin-3 (ATXN3) has emerged as a potential oncogene in a variety of human cancers. ...Conseq …
ATXN3 promotes proliferation, stemness and motility of clear cell renal cell carcinoma cells by regulating S100A8 ubiquitination.
Bai J, Han J, Fan J, Song J, Wang S. Bai J, et al. Physiol Int. 2023 Nov 8;110(4):311-325. doi: 10.1556/2060.2023.00247. Print 2023 Dec 18. Physiol Int. 2023. PMID: 37938238
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a dominant subtype of kidney cancer with a dismal outcome at advanced stages. Ataxin 3 (ATXN3) has been proven to play a cancer-promoting role in several tumors and is upregulated in the patients with ren …
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a dominant subtype of kidney cancer with a dismal outcome at advanced stages. …
ATXN3 functions as a tumor suppresser through potentiating Galectin-9-mediated apoptosis in human colon adenocarcinoma.
Cheng Y, Wang S, Gao Q, Fang D. Cheng Y, et al. J Biol Chem. 2024 May 28:107415. doi: 10.1016/j.jbc.2024.107415. Online ahead of print. J Biol Chem. 2024. PMID: 38815863 Free article.
CRISPR-mediated ATXN3 deletion unexpectedly intensified colon cancer growth both in vitro and in xenograft colon cancers. ...The ectopic expression of Galectin-9 fully reversed the growth of ATXN3-null colon cancer in mice. Furthermore, immunohi …
CRISPR-mediated ATXN3 deletion unexpectedly intensified colon cancer growth both in vitro and in xenograft colon cancers …
Downregulation of ATXN3 Enhances the Sensitivity to AKT Inhibitors (Perifosine or MK-2206), but Decreases the Sensitivity to Chemotherapeutic Drugs (Etoposide or Cisplatin) in Neuroblastoma Cells.
Gong B, Zhang J, Hua Z, Liu Z, Thiele CJ, Li Z. Gong B, et al. Front Oncol. 2021 Jul 12;11:686898. doi: 10.3389/fonc.2021.686898. eCollection 2021. Front Oncol. 2021. PMID: 34322387 Free PMC article.
BACKGROUND: Chemotherapy resistance is the major cause of failure in neuroblastoma (NB) treatment. ATXN3 has been linked to various types of cancer and neurodegenerative diseases; however, its roles in NB have not been established. ...The expression of ATXN3 …
BACKGROUND: Chemotherapy resistance is the major cause of failure in neuroblastoma (NB) treatment. ATXN3 has been linked to various t …
67 results