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1998 1
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397 results

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Page 1
New Immune Role for Axin1 in Colon Cancer Suppression.
Neufeld KL. Neufeld KL. Cell Mol Gastroenterol Hepatol. 2023;15(3):799-800. doi: 10.1016/j.jcmgh.2022.11.011. Epub 2022 Dec 20. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36564008 Free PMC article. No abstract available.
Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/beta-catenin signaling activation (Review).
Katoh M. Katoh M. Int J Mol Med. 2018 Aug;42(2):713-725. doi: 10.3892/ijmm.2018.3689. Epub 2018 May 17. Int J Mol Med. 2018. PMID: 29786110 Free PMC article. Review.
Gain-of-function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss-of-function CTNNB1 mutations …
Gain-of-function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer …
β-Catenin signaling in hepatocellular carcinoma.
Xu C, Xu Z, Zhang Y, Evert M, Calvisi DF, Chen X. Xu C, et al. J Clin Invest. 2022 Feb 15;132(4):e154515. doi: 10.1172/JCI154515. J Clin Invest. 2022. PMID: 35166233 Free PMC article. Review.
Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which encodes beta-catenin, and loss-of-function mutation of AXIN1 occur in approximately 35% of human HCC samples. Human HCCs with activation of the Wnt/beta-catenin pathway demonstrate …
Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which encodes beta-catenin, and loss-of-function muta …
The CK1epsilon/SIAH1 axis regulates AXIN1 stability in colorectal cancer cells.
Yan M, Su Z, Pang X, Wang H, Dai H, Ning J, Liu S, Sun Q, Song J, Zhao X, Lu D. Yan M, et al. Mol Oncol. 2024 Sep;18(9):2277-2297. doi: 10.1002/1878-0261.13624. Epub 2024 Feb 28. Mol Oncol. 2024. PMID: 38419282 Free PMC article.
CK1epsilon has been shown to interact with AXIN1, but its physiological function and role in tumorigenesis remain unknown. In this study, we found that CK1delta/epsilon inhibitors significantly enhanced AXIN1 protein level in colorectal cancer (CRC) cells thr …
CK1epsilon has been shown to interact with AXIN1, but its physiological function and role in tumorigenesis remain unknown. In this st …
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation.
Dai DL, Xie C, Zhong LY, Liu SX, Zhang LL, Zhang H, Wu XP, Wu ZM, Kang K, Li Y, Sun YM, Xia TL, Zhang CS, Zhang A, Shi M, Sun C, Chen ML, Zhao GX, Bu GL, Liu YT, Huang KY, Zhao Z, Li SX, Zhang XY, Yuan YF, Wen SJ, Zhang L, Li BK, Zhong Q, Zeng MS. Dai DL, et al. Signal Transduct Target Ther. 2024 Oct 9;9(1):281. doi: 10.1038/s41392-024-01978-y. Signal Transduct Target Ther. 2024. PMID: 39384753 Free PMC article.
Moreover, KYA1797K, a small molecule that binds to the AXIN1 RGS domain, enhances the AXIN1-IRF3 interaction and promotes the elimination of various highly pathogenic viruses. ...Overall, our findings reveal how AXIN1 regulates IRF3 signaling and phase separa …
Moreover, KYA1797K, a small molecule that binds to the AXIN1 RGS domain, enhances the AXIN1-IRF3 interaction and promotes the …
UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells.
Yang B, Chen W, Tao T, Zhang J, Kong D, Hao J, Yu C, Liao G, Gong H. Yang B, et al. Biol Direct. 2024 May 7;19(1):35. doi: 10.1186/s13062-024-00469-y. Biol Direct. 2024. PMID: 38715121 Free PMC article.
UBE2N interacting with Axin1 was analyzed by co-immunoprecipitation assay. RESULTS: UBE2N was upregulated in prostate cancer and the UBE2N-high expression correlated with the poor prognosis of prostate cancer. ...UBE2N promoted Axin1 ubiquitination and …
UBE2N interacting with Axin1 was analyzed by co-immunoprecipitation assay. RESULTS: UBE2N was upregulated in prostate cancer a …
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM. Zucman-Rossi J, et al. Gastroenterology. 2015 Oct;149(5):1226-1239.e4. doi: 10.1053/j.gastro.2015.05.061. Epub 2015 Jun 20. Gastroenterology. 2015. PMID: 26099527 Review.
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populations, with a minority of patients diagnosed at early stages, when curative treatments are feasible. ...TP53 and CTNNB1 are the next most preva …
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populatio …
AXIN2 promotes degradation of AXIN1 through tankyrase in colorectal cancer cells.
Schmidt O, Brückner M, Bernkopf DB. Schmidt O, et al. FEBS J. 2025 Mar;292(5):1019-1033. doi: 10.1111/febs.17226. Epub 2024 Jul 18. FEBS J. 2025. PMID: 39022865 Free PMC article.
AXIN1 and AXIN2 are homologous proteins that inhibit the Wnt/beta-catenin signaling pathway, which is frequently hyperactive in colorectal cancer. ...Taken together, our data suggest that AXIN2 promotes degradation of AXIN1 through TNKS in colorectal cance …
AXIN1 and AXIN2 are homologous proteins that inhibit the Wnt/beta-catenin signaling pathway, which is frequently hyperactive in color …
FAT4 overexpression promotes antitumor immunity by regulating the beta-catenin/STT3/PD-L1 axis in cervical cancer.
Wang D, Wu S, He J, Sun L, Zhu H, Zhang Y, Liu S, Duan X, Wang Y, Xu T. Wang D, et al. J Exp Clin Cancer Res. 2023 Sep 1;42(1):222. doi: 10.1186/s13046-023-02758-2. J Exp Clin Cancer Res. 2023. PMID: 37658376 Free PMC article.
Here, we report the mechanism by which FAT4 overexpression regulates anti-tumor immunity in cervical cancer by inhibiting PD-L1 N-glycosylation and cell membrane localization in a beta-catenin-dependent manner. ...RESULTS: FAT4 is downregulated in cervical cancer ti …
Here, we report the mechanism by which FAT4 overexpression regulates anti-tumor immunity in cervical cancer by inhibiting PD-L1 N-gly …
Axin1's mystique in manipulating microbiome amidst colitis.
Garrett S, Asada MC, Sun J. Garrett S, et al. Gut Microbes. 2023 Dec;15(2):2286674. doi: 10.1080/19490976.2023.2286674. Epub 2023 Nov 27. Gut Microbes. 2023. PMID: 38010886 Free PMC article.
Classically, Axin1 is considered a regulator of Wnt/beta-catenin signaling. However, Axin1's roles in host-microbial interactions have been unknown. ...Here, we feature several significant conceptual changes, such as differences between Axin1 and Axin2, Ax …
Classically, Axin1 is considered a regulator of Wnt/beta-catenin signaling. However, Axin1's roles in host-microbial interacti …
397 results