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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2000 4
2001 8
2002 12
2003 6
2004 8
2005 10
2006 6
2007 9
2008 13
2009 6
2010 7
2011 13
2012 16
2013 19
2014 18
2015 22
2016 32
2017 25
2018 19
2019 32
2020 24
2021 26
2022 31
2023 30
2024 23

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373 results

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Page 1
New Immune Role for Axin1 in Colon Cancer Suppression.
Neufeld KL. Neufeld KL. Cell Mol Gastroenterol Hepatol. 2023;15(3):799-800. doi: 10.1016/j.jcmgh.2022.11.011. Epub 2022 Dec 20. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36564008 Free PMC article. No abstract available.
A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/beta-catenin signaling pathway to promote gastric cancer progression.
Peng Y, Xu Y, Zhang X, Deng S, Yuan Y, Luo X, Hossain MT, Zhu X, Du K, Hu F, Chen Y, Chang S, Feng X, Fan X, Ashktorab H, Smoot D, Meltzer SJ, Hou G, Wei Y, Li S, Qin Y, Jin Z. Peng Y, et al. Mol Cancer. 2021 Dec 4;20(1):158. doi: 10.1186/s12943-021-01457-w. Mol Cancer. 2021. PMID: 34863211 Free PMC article.
The competitive interaction between AXIN1-295aa and adenomatous polyposis coli (APC) was investigated by immunoprecipitation analyses. ...Mechanistically, AXIN1-295aa competitively interacts with APC, leading to dysfunction of the "destruction complex" of the Wnt pa …
The competitive interaction between AXIN1-295aa and adenomatous polyposis coli (APC) was investigated by immunoprecipitation analyses …
Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/beta-catenin signaling activation (Review).
Katoh M. Katoh M. Int J Mol Med. 2018 Aug;42(2):713-725. doi: 10.3892/ijmm.2018.3689. Epub 2018 May 17. Int J Mol Med. 2018. PMID: 29786110 Free PMC article. Review.
Gain-of-function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss-of-function CTNNB1 mutations …
Gain-of-function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer …
β-Catenin signaling in hepatocellular carcinoma.
Xu C, Xu Z, Zhang Y, Evert M, Calvisi DF, Chen X. Xu C, et al. J Clin Invest. 2022 Feb 15;132(4):e154515. doi: 10.1172/JCI154515. J Clin Invest. 2022. PMID: 35166233 Free PMC article. Review.
Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which encodes beta-catenin, and loss-of-function mutation of AXIN1 occur in approximately 35% of human HCC samples. Human HCCs with activation of the Wnt/beta-catenin pathway demonstrate …
Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which encodes beta-catenin, and loss-of-function muta …
Axin1's mystique in manipulating microbiome amidst colitis.
Garrett S, Asada MC, Sun J. Garrett S, et al. Gut Microbes. 2023 Dec;15(2):2286674. doi: 10.1080/19490976.2023.2286674. Epub 2023 Nov 27. Gut Microbes. 2023. PMID: 38010886 Free PMC article.
Classically, Axin1 is considered a regulator of Wnt/beta-catenin signaling. However, Axin1's roles in host-microbial interactions have been unknown. ...Here, we feature several significant conceptual changes, such as differences between Axin1 and Axin2, Ax …
Classically, Axin1 is considered a regulator of Wnt/beta-catenin signaling. However, Axin1's roles in host-microbial interacti …
TRIM37 promotes gallbladder cancer proliferation by activating the Wnt/beta-catenin pathway via ubiquitination of Axin1.
Xu M, Jiang B, Man Z, Zhu H. Xu M, et al. Transl Oncol. 2023 Sep;35:101732. doi: 10.1016/j.tranon.2023.101732. Epub 2023 Jun 26. Transl Oncol. 2023. PMID: 37379772 Free PMC article.
BACKGROUND: Gallbladder cancer (GBC) is among the most lethal malignancies in the world, with a prognosis that is extremely poor. The results of previous studies suggest that tripartite motif containing 37 (TRIM37) contributes to the progression of numerous types of can …
BACKGROUND: Gallbladder cancer (GBC) is among the most lethal malignancies in the world, with a prognosis that is extremely poor. The …
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM. Zucman-Rossi J, et al. Gastroenterology. 2015 Oct;149(5):1226-1239.e4. doi: 10.1053/j.gastro.2015.05.061. Epub 2015 Jun 20. Gastroenterology. 2015. PMID: 26099527 Review.
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populations, with a minority of patients diagnosed at early stages, when curative treatments are feasible. ...TP53 and CTNNB1 are the next most preva …
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populatio …
RSK2 inactivation cooperates with AXIN1 inactivation or beta-catenin activation to promote hepatocarcinogenesis.
Schaeffer S, Gupta B, Calatayud AL, Calderaro J, Caruso S, Hirsch TZ, Pelletier L, Zucman-Rossi J, Rebouissou S. Schaeffer S, et al. J Hepatol. 2023 Sep;79(3):704-716. doi: 10.1016/j.jhep.2023.05.004. Epub 2023 May 16. J Hepatol. 2023. PMID: 37201672
RESULTS: RSK2-inactivating mutations are specific to human HCC and frequently co-occur with AXIN1-inactivating or beta-catenin-activating mutations. Modelling of these co-occurrences in mice showed a cooperative effect in promoting liver tumours with transcriptomic profile …
RESULTS: RSK2-inactivating mutations are specific to human HCC and frequently co-occur with AXIN1-inactivating or beta-catenin-activa …
Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population.
Li Q, Zhang P, Wang Y, Zhang Y, Li K, Song Y, Su M, Zhou B, Zhang L. Li Q, et al. Dis Markers. 2019 Apr 15;2019:3949343. doi: 10.1155/2019/3949343. eCollection 2019. Dis Markers. 2019. PMID: 31143301 Free PMC article.
BACKGROUND: Previous evidence has indicated that the reduction of axis inhibition protein 1 (AXIN1) expression is related with the poor differentiation of non-small-cell lung cancer (NSCLC). However, the potential association between AXIN1 and bladder canc …
BACKGROUND: Previous evidence has indicated that the reduction of axis inhibition protein 1 (AXIN1) expression is related with the po …
FAT4 overexpression promotes antitumor immunity by regulating the beta-catenin/STT3/PD-L1 axis in cervical cancer.
Wang D, Wu S, He J, Sun L, Zhu H, Zhang Y, Liu S, Duan X, Wang Y, Xu T. Wang D, et al. J Exp Clin Cancer Res. 2023 Sep 1;42(1):222. doi: 10.1186/s13046-023-02758-2. J Exp Clin Cancer Res. 2023. PMID: 37658376 Free PMC article.
Here, we report the mechanism by which FAT4 overexpression regulates anti-tumor immunity in cervical cancer by inhibiting PD-L1 N-glycosylation and cell membrane localization in a beta-catenin-dependent manner. ...Through functional and mechanistic experiments in vivo and …
Here, we report the mechanism by which FAT4 overexpression regulates anti-tumor immunity in cervical cancer by inhibiting PD-L1 N-gly …
373 results