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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER.
Motani K, Saito-Tarashima N, Nishino K, Yamauchi S, Minakawa N, Kosako H. Motani K, et al. Cell Rep. 2022 Dec 20;41(12):111868. doi: 10.1016/j.celrep.2022.111868. Cell Rep. 2022. PMID: 36543137 Free article.
Depletion of ACBD3 impairs STING ER-to-Golgi trafficking and type-I IFN responses. Our results identify the ACBD3-mediated non-canonical cargo concentration system that drives the ER exit of STING....
Depletion of ACBD3 impairs STING ER-to-Golgi trafficking and type-I IFN responses. Our results identify the ACBD3-mediated non …
ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells.
Houghton-Gisby J, Kerslake R, Karteris E, Mokbel K, Harvey AJ. Houghton-Gisby J, et al. Int J Mol Sci. 2022 Aug 10;23(16):8881. doi: 10.3390/ijms23168881. Int J Mol Sci. 2022. PMID: 36012147 Free PMC article.
ACBD3 overexpression has previously been found to correlate with worse prognosis for breast cancer patients and, as an incredibly diverse protein in both function and cellular localisation, ACBD3 may have a larger role in breast cancer than previously thought. This …
ACBD3 overexpression has previously been found to correlate with worse prognosis for breast cancer patients and, as an incredibly div …
Identification of ACBD3 as a new molecular biomarker in pan-cancers through bioinformatic analysis: a preclinical study.
Ma X, Huang S, Shi H, Luo R, Luo B, Tan Z, Shi L, Zhang W, Yang W, Zhong X, Lü M, Chen X, Tang X. Ma X, et al. Eur J Med Res. 2023 Dec 14;28(1):590. doi: 10.1186/s40001-023-01576-8. Eur J Med Res. 2023. PMID: 38098097 Free PMC article.
Although the precise roles of ACBD3 in various cancers remain unclear. Thus, we aimed to determine the diverse roles of ACBD3 in pan-cancers. ...ACBD3 may also provide new directions for cancer treatment targets in the future....
Although the precise roles of ACBD3 in various cancers remain unclear. Thus, we aimed to determine the diverse roles of ACBD3 …
ACBD3 is required for FAPP2 transferring glucosylceramide through maintaining the Golgi integrity.
Liao J, Guan Y, Chen W, Shi C, Yao D, Wang F, Lam SM, Shui G, Cao X. Liao J, et al. J Mol Cell Biol. 2019 Feb 1;11(2):107-117. doi: 10.1093/jmcb/mjy030. J Mol Cell Biol. 2019. PMID: 29750412 Free PMC article.
Here, we identify a Golgi-resident protein, acyl-coenzyme A binding domain containing 3 (ACBD3), as an interacting partner of FAPP2. We find that ACBD3 knockdown leads to dramatic Golgi fragmentation, which subsequently causes FAPP2 dispersal throughout the cytoplas …
Here, we identify a Golgi-resident protein, acyl-coenzyme A binding domain containing 3 (ACBD3), as an interacting partner of FAPP2. …
ACBD3 is up-regulated in gastric cancer and promotes cell cycle G1-to-S transition in an AKT-dependent manner.
Zheng Y, Pei Y, Tang R, Zhou X, Feng Z, Li D, Chen H, Zeng Z, Jiang L, Cai J, Mao P, Wang L. Zheng Y, et al. Exp Cell Res. 2021 Sep 15;406(2):112752. doi: 10.1016/j.yexcr.2021.112752. Epub 2021 Jul 30. Exp Cell Res. 2021. PMID: 34332983 Free article.
AKT inhibitors were used to deeply explore the molecular regulation mechanism of ACBD3. The results showed that the elevated ACBD3 in gastric cancer tissue were positively correlated with the clinical grade and prognosis of gastric cancer. ...At the same time, the a …
AKT inhibitors were used to deeply explore the molecular regulation mechanism of ACBD3. The results showed that the elevated ACBD3 …
Acyl-CoA-Binding Domain-Containing 3 (ACBD3; PAP7; GCP60): A Multi-Functional Membrane Domain Organizer.
Yue X, Qian Y, Gim B, Lee I. Yue X, et al. Int J Mol Sci. 2019 Apr 24;20(8):2028. doi: 10.3390/ijms20082028. Int J Mol Sci. 2019. PMID: 31022988 Free PMC article. Review.
Acyl-CoA-binding domain-containing 3 (ACBD3) is a multi-functional scaffolding protein, which has been associated with a diverse array of cellular functions, including steroidogenesis, embryogenesis, neurogenesis, Huntington's disease (HD), membrane trafficking, and viral/ …
Acyl-CoA-binding domain-containing 3 (ACBD3) is a multi-functional scaffolding protein, which has been associated with a diverse arra …
ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier.
Yue X, Qian Y, Zhu L, Gim B, Bao M, Jia J, Jing S, Wang Y, Tan C, Bottanelli F, Ziltener P, Choi S, Hao P, Lee I. Yue X, et al. BMC Biol. 2021 Sep 7;19(1):194. doi: 10.1186/s12915-021-01137-7. BMC Biol. 2021. PMID: 34493279 Free PMC article.
We demonstrate that ACBD3 directly interact with KDEL receptor and form a functionally distinct protein complex in ArfGAPs-independent manner. Depletion of ACBD3 results in re-localization of KDEL receptor to the ER by inducing accelerated retrograde trafficking of …
We demonstrate that ACBD3 directly interact with KDEL receptor and form a functionally distinct protein complex in ArfGAPs-independen …
ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB.
Lyoo H, van der Schaar HM, Dorobantu CM, Rabouw HH, Strating JRPM, van Kuppeveld FJM. Lyoo H, et al. mBio. 2019 Feb 12;10(1):e02742-18. doi: 10.1128/mBio.02742-18. mBio. 2019. PMID: 30755512 Free PMC article.
Here, we investigated the role of acyl-coenzyme A binding domain containing 3 (ACBD3) in PI4KB recruitment upon enterovirus replication using ACBD3 knockout (ACBD3(KO)) cells. ...By testing ACBD3 and PI4KB mutants that abrogate the ACBD3-PI4KB i …
Here, we investigated the role of acyl-coenzyme A binding domain containing 3 (ACBD3) in PI4KB recruitment upon enterovirus replicati …
An A-kinase anchoring protein (ACBD3) coordinates traffic-induced PKA activation at the Golgi.
Jia J, Tang S, Yue X, Jing S, Zhu L, Tan C, Gao J, Du Y, Lee I, Qian Y. Jia J, et al. J Biol Chem. 2023 May;299(5):104696. doi: 10.1016/j.jbc.2023.104696. Epub 2023 Apr 10. J Biol Chem. 2023. PMID: 37044218 Free PMC article.
In this study, we showed that the GOLD domain of ACBD3 directly interacts with the regulatory subunit II (RII) of PKA and effectively recruits PKA holoenzyme to the Golgi. ...Taken together, these data demonstrate that ACBD3 coordinates the protein secretory pathway …
In this study, we showed that the GOLD domain of ACBD3 directly interacts with the regulatory subunit II (RII) of PKA and effectively …
ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP.
Yue X, Bao M, Christiano R, Li S, Mei J, Zhu L, Mao F, Yue Q, Zhang P, Jing S, Rothman JE, Qian Y, Lee I. Yue X, et al. FEBS Lett. 2017 Sep;591(18):2793-2802. doi: 10.1002/1873-3468.12780. Epub 2017 Aug 21. FEBS Lett. 2017. PMID: 28777890 Free article.
Furthermore, ACBD3 recruits TBC1D22, a Rab33b GTPase activating protein (GAP), to a large multi-protein complex containing Golgin45 and GRASP55. These results suggest that ACBD3 may provide a scaffolding to organize the Golgi stacking proteins and a Rab33b-GAP at th …
Furthermore, ACBD3 recruits TBC1D22, a Rab33b GTPase activating protein (GAP), to a large multi-protein complex containing Golgin45 a …
91 results