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Page 1
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Liang C, Wang X, Zhang Z, Xiao F, Feng H, Ma Q, Huang J, Qiang G, Zhong D, Liu D. Liang C, et al. Transl Lung Cancer Res. 2020 Oct;9(5):1885-1903. doi: 10.21037/tlcr-19-509. Transl Lung Cancer Res. 2020. PMID: 33209610 Free PMC article.
Furthermore, we explored the potential molecular mechanisms of ACOT11 with immunoprecipitation. RESULTS: We found high expression of ACOT11 in tumor samples. ...It also promoted the cell apoptosis and cell cycle arrest via multiple signaling pathways. Additionally, …
Furthermore, we explored the potential molecular mechanisms of ACOT11 with immunoprecipitation. RESULTS: We found high expression of …
Novel Alzheimer's disease genes and epistasis identified using machine learning GWAS platform.
Lundberg M, Sng LMF, Szul P, Dunne R, Bayat A, Burnham SC, Bauer DC, Twine NA. Lundberg M, et al. Sci Rep. 2023 Oct 17;13(1):17662. doi: 10.1038/s41598-023-44378-y. Sci Rep. 2023. PMID: 37848535 Free PMC article.
SASH1 is involved in a triplet interaction with pathogenic APOE SNP and ACOT11, where the SASH1 SNP lowered the pathogenic interaction effect between ACOT11 and APOE. ...
SASH1 is involved in a triplet interaction with pathogenic APOE SNP and ACOT11, where the SASH1 SNP lowered the pathogenic interactio …
A genome-wide association study for varicose veins.
Lee ML, Liang C, Chuang CH, Lee PS, Chen TH, Sun S, Liao KW, Huang HD. Lee ML, et al. Phlebology. 2022 May;37(4):267-278. doi: 10.1177/02683555211069248. Epub 2022 Jan 31. Phlebology. 2022. PMID: 35099328
A further comparison between C2-3 patient subgroup and C4-6 subgroup identified another four significant SNPs, which were located in ZNF664-FAM101A, PHF2, ACOT11, and TOM1L1 genes. CONCLUSION: Our preliminary result identified six significant SNPs located in six different …
A further comparison between C2-3 patient subgroup and C4-6 subgroup identified another four significant SNPs, which were located in ZNF664- …
Dissecting the alternation landscape of mitochondrial metabolism-related genes in lung adenocarcinoma and their latent mechanisms.
Jin X, Liu D, Kong D, Zhou X, Zheng L, Xu C. Jin X, et al. Aging (Albany NY). 2023 Jun 15;15(12):5482-5496. doi: 10.18632/aging.204803. Epub 2023 Jun 15. Aging (Albany NY). 2023. PMID: 37335087 Free PMC article.
Then, we figured out three hub prognosis-associated MMRGs (also termed as PMMRGs: ACOT11, ALDH2, and TXNRD1) that were engaged in the evolution of LUAD. ...
Then, we figured out three hub prognosis-associated MMRGs (also termed as PMMRGs: ACOT11, ALDH2, and TXNRD1) that were engaged in the …
Overexpression and proliferation dependence of acyl-CoA thioesterase 11 and 13 in lung adenocarcinoma.
Hung JY, Chiang SR, Liu KT, Tsai MJ, Huang MS, Shieh JM, Yen MC, Hsu YL. Hung JY, et al. Oncol Lett. 2017 Sep;14(3):3647-3656. doi: 10.3892/ol.2017.6594. Epub 2017 Jul 18. Oncol Lett. 2017. PMID: 28927126 Free PMC article.
Compared with adjacent non-tumor lung tissue, lung adenocarcinoma tissue exhibited significantly higher ACOT11 and ACOT13 expression. Kaplan-Meier plotter database analysis demonstrated that high levels of ACOT11 and ACOT13 were associated with a worse overall survi …
Compared with adjacent non-tumor lung tissue, lung adenocarcinoma tissue exhibited significantly higher ACOT11 and ACOT13 expression. …
Functional and structural properties of mammalian acyl-coenzyme A thioesterases.
Kirkby B, Roman N, Kobe B, Kellie S, Forwood JK. Kirkby B, et al. Prog Lipid Res. 2010 Oct;49(4):366-77. doi: 10.1016/j.plipres.2010.04.001. Epub 2010 May 12. Prog Lipid Res. 2010. PMID: 20470824 Review.
These include the structure determination of both type-I and type-II Acot family members, structural elucidation of the START domain of ACOT11, identification of roles in arachidonic acid and inflammatory prostaglandin production by Acot7, and inclusion of a 13th Acot fami …
These include the structure determination of both type-I and type-II Acot family members, structural elucidation of the START domain of A …
Acyl-CoA Thioesterase 8 and 11 as Novel Biomarkers for Clear Cell Renal Cell Carcinoma.
Xu CL, Chen L, Li D, Chen FT, Sha ML, Shao Y. Xu CL, et al. Front Genet. 2020 Dec 10;11:594969. doi: 10.3389/fgene.2020.594969. eCollection 2020. Front Genet. 2020. PMID: 33362855 Free PMC article.
RESULTS: ACOT1/2/8/11/13 were found to be significantly downregulated in ccRCC samples. In particular, ACOT11 was decreased in almost every matched normal-tumor pair, and had extremely high diagnostic value as shown by ROC curve analysis (AUC = 0.964). The expression of …
RESULTS: ACOT1/2/8/11/13 were found to be significantly downregulated in ccRCC samples. In particular, ACOT11 was decreased in almost …
Regulatory mechanism of fatty acid‑CoA metabolic enzymes under endoplasmic reticulum stress in lung cancer.
Liu KT, Yeh IJ, Chou SK, Yen MC, Kuo PL. Liu KT, et al. Oncol Rep. 2018 Nov;40(5):2674-2682. doi: 10.3892/or.2018.6664. Epub 2018 Aug 21. Oncol Rep. 2018. PMID: 30132556
Evaluation of PRECOG and Kaplan-Meier plotter databases in the present study suggested that high expression of acyl-CoA thioesterase (ACOT)7, ACOT11, ACOT13, soluble carrier family 27 member A4 (SLC27A4) and SLC27A5 was associated with poor clinical outcomes. In addition, …
Evaluation of PRECOG and Kaplan-Meier plotter databases in the present study suggested that high expression of acyl-CoA thioesterase (ACOT)7 …
New players on the metabolic stage: How do you like Them Acots?
Cohen DE. Cohen DE. Adipocyte. 2013 Jan 1;2(1):3-6. doi: 10.4161/adip.21853. Adipocyte. 2013. PMID: 23700546 Free PMC article.
Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly upregulated when mice are exposed to cold ambient te …
Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily membe …
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J. Ohtomo T, et al. Biochem Biophys Rep. 2017 Feb 20;10:32-38. doi: 10.1016/j.bbrep.2017.02.002. eCollection 2017 Jul. Biochem Biophys Rep. 2017. PMID: 28955734 Free PMC article.
In C57BL/6J mice fed a high-fat diet (HFD) over 2-4 weeks, carnitine palmitoyltransferase 2 (Cpt2), acyl-CoA thioesterase (Acot) 2, Acot11 and Ucp1 levels were significantly increased compared with baseline and control low-fat diet (LFD)-fed mice. ...Extramitochondrial …
In C57BL/6J mice fed a high-fat diet (HFD) over 2-4 weeks, carnitine palmitoyltransferase 2 (Cpt2), acyl-CoA thioesterase (Acot) 2, Acot1 …
22 results