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64 results

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Page 1
High Expression of ACOT2 Predicts Worse Overall Survival and Abnormal Lipid Metabolism: A Potential Target for Acute Myeloid Leukemia.
Yin X, Lyu C, Li Z, Wang Q, Ding Y, Wang Y, Qiu Y, Cui S, Guo D, Xu R. Yin X, et al. J Healthc Eng. 2022 Sep 23;2022:2669114. doi: 10.1155/2022/2669114. eCollection 2022. J Healthc Eng. 2022. PMID: 36193167 Free PMC article.
The protein-protein interaction (PPI) network of ACOT2 coexpressed genes and functional ACOT2-related metabolites association network were constructed based on GeneMANIA and Human Metabolome Database. ...Collectively, the increase of ACOT2 may be an important …
The protein-protein interaction (PPI) network of ACOT2 coexpressed genes and functional ACOT2-related metabolites association …
The effect of Acot2 overexpression or downregulation on the preadipocyte differentiation in Chinese Red Steppe cattle.
Liu L, Wu J, Gao Y, Lv Y, Xue J, Qin L, Xiao C, Hu Z, Zhang L, Luo X, Wang Y, Cao Y, Cao Y, Zhang G. Liu L, et al. Adipocyte. 2020 Dec;9(1):279-289. doi: 10.1080/21623945.2020.1776553. Adipocyte. 2020. PMID: 32579860 Free PMC article.
In this work, we detected the expression of the Acot2 gene during the adipocyte differentiation in Chinese Red Steppe cattle, and then interfered and overexpressed the Acot2 gene in the preadipocytes to explore its regulatory role in the adipocyte differentiation. T …
In this work, we detected the expression of the Acot2 gene during the adipocyte differentiation in Chinese Red Steppe cattle, and the …
Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins.
Ma S, Shi S, Xu B, Liu M, Xie L, Su Y, Li J, Liang Q, Ye S, Wang Y. Ma S, et al. mSystems. 2024 Jan 23;9(1):e0097323. doi: 10.1128/msystems.00973-23. Epub 2023 Dec 19. mSystems. 2024. PMID: 38112462 Free PMC article.
Docking models provided insights into the binding pocket of viral polypeptides and the catalytic mechanism of ACOT2. Notably, this study is the first to demonstrate that ACOT2 functions as a serine protease to hydrolyze protein substrates. ...How DENV efficiently hi …
Docking models provided insights into the binding pocket of viral polypeptides and the catalytic mechanism of ACOT2. Notably, this st …
Acyl-CoA thioesterase-2 facilitates β-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner.
Bekeova C, Han JI, Xu H, Kerr E, Blackburne B, Lynch SC, Mesaros C, Murgia M, Vadigepalli R, Beld J, Leonardi R, Snyder NW, Seifert EL. Bekeova C, et al. bioRxiv [Preprint]. 2023 Jun 27:2023.06.27.546724. doi: 10.1101/2023.06.27.546724. bioRxiv. 2023. PMID: 37425757 Free PMC article. Preprint.
Thus, we reasoned that ACOT2 may constitutively regulate matrix acyl-CoA levels. Acot2 deletion in murine skeletal muscle (SM) resulted in acyl-CoA build-up when lipid supply and energy demands were modest. ...In mice fed a high fat diet, ACOT2 enabled the ac …
Thus, we reasoned that ACOT2 may constitutively regulate matrix acyl-CoA levels. Acot2 deletion in murine skeletal muscle (SM) …
Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2).
Mandel CR, Tweel B, Tong L. Mandel CR, et al. Biochem Biophys Res Commun. 2009 Aug 7;385(4):630-3. doi: 10.1016/j.bbrc.2009.05.122. Epub 2009 Jun 2. Biochem Biophys Res Commun. 2009. PMID: 19497300 Free PMC article.
We report here the crystal structure at 2.1A resolution of human mitochondrial ACOT2, a type I enzyme. The structure contains two domains, N and C domains. ...
We report here the crystal structure at 2.1A resolution of human mitochondrial ACOT2, a type I enzyme. The structure contains two dom …
Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.
Moffat C, Bhatia L, Nguyen T, Lynch P, Wang M, Wang D, Ilkayeva OR, Han X, Hirschey MD, Claypool SM, Seifert EL. Moffat C, et al. J Lipid Res. 2014 Dec;55(12):2458-70. doi: 10.1194/jlr.M046961. Epub 2014 Aug 11. J Lipid Res. 2014. PMID: 25114170 Free PMC article.
Using a model of adenoviral Acot2 overexpression in mouse liver (Ad-Acot2), we show that Acot2 increases the utilization of FA substrate during the daytime in ad libitum-fed mice, but the nighttime switch to carbohydrate oxidation is similar to control mice. …
Using a model of adenoviral Acot2 overexpression in mouse liver (Ad-Acot2), we show that Acot2 increases the utilizatio …
Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.
Bekeova C, Anderson-Pullinger L, Boye K, Boos F, Sharpadskaya Y, Herrmann JM, Seifert EL. Bekeova C, et al. J Biol Chem. 2019 Dec 13;294(50):19034-19047. doi: 10.1074/jbc.RA119.010901. Epub 2019 Nov 1. J Biol Chem. 2019. PMID: 31676684 Free PMC article.
Here, we compared the suborganellar localization, activity, expression, and regulation among mitochondrial Acots (Acot2, -7, -9, and -13) in mitochondria from multiple mouse tissues and from a model of Acot2 depletion. ...Matrix Acots occupied different functional n …
Here, we compared the suborganellar localization, activity, expression, and regulation among mitochondrial Acots (Acot2, -7, -9, and …
Regulated expression of acyl-CoA thioesterases in the differentiation of cultured rat brown adipocytes.
Momose A, Fujita M, Ohtomo T, Umemoto N, Tanonaka K, Toyoda H, Morikawa M, Yamada J. Momose A, et al. Biochem Biophys Res Commun. 2011 Jan 7;404(1):74-8. doi: 10.1016/j.bbrc.2010.11.066. Epub 2010 Nov 20. Biochem Biophys Res Commun. 2011. PMID: 21094633
Western blotting confirmed that, in contrast to ACOT1, the ACOT2 expression level was very low in the preadipocytes. However, after differentiation, the ACOT1 level fell to one-half of the baseline level and ACOT2 increased 18-fold. ACOT2 expression in the di …
Western blotting confirmed that, in contrast to ACOT1, the ACOT2 expression level was very low in the preadipocytes. However, after d …
Combined transcriptomic and lipidomic analysis reveals aberrant lipid metabolism in central nervous system hemangioblastomas.
Wang Q, Liu W, Zhang S, Liang Z, Jiang L, Xue A, Cen X, Bu Q. Wang Q, et al. Sci Rep. 2021 Jan 14;11(1):1314. doi: 10.1038/s41598-020-80263-8. Sci Rep. 2021. PMID: 33446752 Free PMC article.
Transcriptomic analysis revealed differential expression of several genes between the solid and cystic HBs, and those associated with lipid metabolism, such as ADCY4, MGLL, ACOT2, DGKG, SHC1 and LPAR2, were markedly dysregulated in the cystic HBs. ...
Transcriptomic analysis revealed differential expression of several genes between the solid and cystic HBs, and those associated with lipid …
Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
St Clair LA, Mills SA, Lian E, Soma PS, Nag A, Montgomery C, Ramirez G, Chotiwan N, Gullberg RC, Perera R. St Clair LA, et al. Viruses. 2022 Jan 25;14(2):240. doi: 10.3390/v14020240. Viruses. 2022. PMID: 35215835 Free PMC article.
The loss of function of the type I ACOTs 1 (cytoplasmic) and 2 (mitochondrial) together significantly increased DENV serotype 2 (DENV2) viral replication and infectious particle release. However, isolated knockdown of mitochondrial ACOT2 significantly decreased DENV2 prote …
The loss of function of the type I ACOTs 1 (cytoplasmic) and 2 (mitochondrial) together significantly increased DENV serotype 2 (DENV2) vira …
64 results