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Year Number of Results
1962 1
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1980 3
1982 1
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1986 2
1987 1
1989 1
1990 1
1991 2
1992 2
1993 4
1994 1
1995 2
1996 3
1997 2
1998 2
1999 1
2000 4
2003 1
2004 1
2005 3
2006 1
2008 5
2009 2
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2012 5
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2015 4
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122 results

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Page 1
ACY1 regulating PTEN/PI3K/AKT signaling in the promotion of non-small cell lung cancer progression.
Chen H, Wang W, Xiao C, Xia D, Li F, Liu S. Chen H, et al. Ann Transl Med. 2021 Sep;9(17):1378. doi: 10.21037/atm-21-3127. Ann Transl Med. 2021. PMID: 34733930 Free PMC article.
Overexpression of ACY1 significantly increased cell growth, migration, invasion, and tumorigenesis, and reduced cell apoptosis, indicating that ACY1 functions as an oncogene in NSCLC. ...Overexpression of PTEN diminished the effects of ACY1 upregulation on ce …
Overexpression of ACY1 significantly increased cell growth, migration, invasion, and tumorigenesis, and reduced cell apoptosis, indic …
ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/beta-Catenin Signaling Pathway.
Shan W, Dai C, Zhang H, Han D, Yi Q, Xia B. Shan W, et al. Cancers (Basel). 2022 Nov 21;14(22):5704. doi: 10.3390/cancers14225704. Cancers (Basel). 2022. PMID: 36428796 Free PMC article.
Mechanistically, TCGA data demonstrated that ACY1 expression was closely related to the Wnt/beta-catenin pathway in CRC. ...In conclusion, ACY1 downregulation could enhance the radiosensitivity of cetuximab-resistant CRC by inactivating Wnt/beta-catenin signaling, i …
Mechanistically, TCGA data demonstrated that ACY1 expression was closely related to the Wnt/beta-catenin pathway in CRC. ...In conclu …
A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain.
Liu B, Wu W, Cui L, Zheng X, Li N, Zhang X, Duan G. Liu B, et al. iScience. 2023 May 28;26(6):106989. doi: 10.1016/j.isci.2023.106989. eCollection 2023 Jun 16. iScience. 2023. PMID: 37378314 Free PMC article.
Moreover, spinal ACY1 overexpression induced mechanical allodynia in naive mice, while ACY1 suppression alleviated inflammatory and neuropathic pain. ...In conclusion, ACY1 acts as a common downstream effector protein of Nav1.8 in inflammatory and neuropathic …
Moreover, spinal ACY1 overexpression induced mechanical allodynia in naive mice, while ACY1 suppression alleviated inflammator …
Menkes disease complicated by concurrent ACY1 deficiency: A case report.
Mauri A, Saielli LA, Alfei E, Iascone M, Marchetti D, Cattaneo E, Di Lauro A, Antonelli L, Alberti L, Bonaventura E, Veggiotti P, Spaccini L, Cereda C. Mauri A, et al. Front Genet. 2023 Mar 2;14:1077625. doi: 10.3389/fgene.2023.1077625. eCollection 2023. Front Genet. 2023. PMID: 36936426 Free PMC article.
Aminoacylase-1 deficiency is a rare inborn error of metabolism caused by homozygous or compound heterozygous variant in the ACY1 gene, characterized by increased urinary excretion of specific N-acetyl amino acids. ...Whole-exome sequencing analysis (WES) revealed the novel …
Aminoacylase-1 deficiency is a rare inborn error of metabolism caused by homozygous or compound heterozygous variant in the ACY1 gene …
Study of the expression and function of ACY1 in patients with colorectal cancer.
Yu B, Liu X, Cao X, Zhang M, Chang H. Yu B, et al. Oncol Lett. 2017 Apr;13(4):2459-2464. doi: 10.3892/ol.2017.5702. Epub 2017 Feb 8. Oncol Lett. 2017. PMID: 28454420 Free PMC article.
Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. ...This ACY1 mRNA expression was found to be positively correlated with tumor stage. ...
Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. ...This ACY1 mRNA expression …
Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites.
Bomba L, Walter K, Guo Q, Surendran P, Kundu K, Nongmaithem S, Karim MA, Stewart ID, Langenberg C, Danesh J, Di Angelantonio E, Roberts DJ, Ouwehand WH; INTERVAL study; Dunham I, Butterworth AS, Soranzo N. Bomba L, et al. Am J Hum Genet. 2022 Jun 2;109(6):1038-1054. doi: 10.1016/j.ajhg.2022.04.009. Epub 2022 May 13. Am J Hum Genet. 2022. PMID: 35568032 Free PMC article.
We developed algorithms to prioritize putative driver variants at each locus and used mediation and Mendelian randomization analyses to test directionality at associations of metabolite and protein levels at the ACY1 locus. Overall, 66% of reported associations implicate g …
We developed algorithms to prioritize putative driver variants at each locus and used mediation and Mendelian randomization analyses to test …
Aminoacylase I deficiency due to ACY1 mRNA exon skipping.
Ferri L, Funghini S, Fioravanti A, Biondi EG, la Marca G, Guerrini R, Donati MA, Morrone A. Ferri L, et al. Clin Genet. 2014 Oct;86(4):367-72. doi: 10.1111/cge.12297. Epub 2013 Nov 18. Clin Genet. 2014. PMID: 24117009
Aminoacylase 1 (ACY1) deficiency is a rare inborn error of metabolism of which less than 20 observations have been described. ...Our data endorse the hypothesis of a link between this inborn error of metabolism and the neurological manifestations observed in patients with …
Aminoacylase 1 (ACY1) deficiency is a rare inborn error of metabolism of which less than 20 observations have been described. ...Our …
Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism.
Sass JO, Mohr V, Olbrich H, Engelke U, Horvath J, Fliegauf M, Loges NT, Schweitzer-Krantz S, Moebus R, Weiler P, Kispert A, Superti-Furga A, Wevers RA, Omran H. Sass JO, et al. Am J Hum Genet. 2006 Mar;78(3):401-9. doi: 10.1086/500563. Epub 2006 Jan 18. Am J Hum Genet. 2006. PMID: 16465618 Free PMC article.
Nuclear magnetic resonance spectroscopy analysis of urine samples detected a distinct pattern of N-acetylated metabolites, consistent with ACY1 dysfunction. Functional analyses of patients' lymphoblasts demonstrated ACY1 deficiency. Mutation analysis uncovered reces …
Nuclear magnetic resonance spectroscopy analysis of urine samples detected a distinct pattern of N-acetylated metabolites, consistent with …
LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma.
Wang G, Li H, Hou Y. Wang G, et al. Cancer Gene Ther. 2022 May;29(5):585-596. doi: 10.1038/s41417-021-00339-z. Epub 2021 May 17. Cancer Gene Ther. 2022. PMID: 34002044
MAGI2-AS3 bound with HEY1 and reduced the HEY1 enrichment at the ACY1 promoter region, thus increasing ACY1 gene transcription. HEY1 knockdown or ACY1 overexpression that resisted MAGI2-AS3 knockdown was found in the in vivo and in vitro settings. The present …
MAGI2-AS3 bound with HEY1 and reduced the HEY1 enrichment at the ACY1 promoter region, thus increasing ACY1 gene transcription …
N-Acetylglutamate and N-acetylmethionine compromise mitochondrial bioenergetics homeostasis and glutamate oxidation in brain of developing rats: Potential implications for the pathogenesis of ACY1 deficiency.
Bortoluzzi VT, Ribeiro RT, Pinheiro CV, Castro ET, Tavares TQ, Leipnitz G, Sass JO, Castilho RF, Amaral AU, Wajner M. Bortoluzzi VT, et al. Biochem Biophys Res Commun. 2023 Dec 3;684:149123. doi: 10.1016/j.bbrc.2023.149123. Epub 2023 Oct 17. Biochem Biophys Res Commun. 2023. PMID: 37871522
Aminoacylase 1 (ACY1) deficiency is an inherited metabolic disorder biochemically characterized by high urinary concentrations of aliphatic N-acetylated amino acids and associated with a broad clinical spectrum with predominant neurological signs. Considering that the path …
Aminoacylase 1 (ACY1) deficiency is an inherited metabolic disorder biochemically characterized by high urinary concentrations of ali …
122 results