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Page 1
Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors.
Scribner JA, Hicks SW, Sinkevicius KW, Yoder NC, Diedrich G, Brown JG, Lucas J, Fuller ME, Son T, Dastur A, Hooley J, Espelin C, Themeles M, Chen FZ, Li Y, Chiechi M, Lee J, Barat B, Widjaja L, Gorlatov S, Tamura J, Ciccarone V, Ab O, McEachem KA, Koenig S, Westin EH, Moore PA, Chittenden T, Gregory RJ, Bonvini E, Loo D. Scribner JA, et al. Mol Cancer Ther. 2022 Jul 5;21(7):1047-1059. doi: 10.1158/1535-7163.MCT-21-0915. Mol Cancer Ther. 2022. PMID: 35511740
ADAM metallopeptidase domain 9 (ADAM9) is a member of the ADAM family of multifunctional, multidomain type 1 transmembrane proteins. ...Subsequent analysis revealed anti-ADAM9 antibodies were efficiently internalized and processed by tumor cells making ADAM9 …
ADAM metallopeptidase domain 9 (ADAM9) is a member of the ADAM family of multifunctional, multidomain type 1 transmembrane proteins. …
The pleiotropic roles of ADAM9 in the biology of solid tumors.
Oria VO, Lopatta P, Schilling O. Oria VO, et al. Cell Mol Life Sci. 2018 Jul;75(13):2291-2301. doi: 10.1007/s00018-018-2796-x. Epub 2018 Mar 17. Cell Mol Life Sci. 2018. PMID: 29550974 Review.
In each of these tumors, ADAM9 may contribute to tumor biology via proteolytic or non-proteolytic mechanisms. ...ADAM9 may also contribute to tumor biology in non-proteolytic ways probably through interaction with different integrins. ...
In each of these tumors, ADAM9 may contribute to tumor biology via proteolytic or non-proteolytic mechanisms. ...ADAM9 may als …
An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases.
Chou CW, Huang YK, Kuo TT, Liu JP, Sher YP. Chou CW, et al. Int J Mol Sci. 2020 Oct 21;21(20):7790. doi: 10.3390/ijms21207790. Int J Mol Sci. 2020. PMID: 33096780 Free PMC article. Review.
ADAM9 influences the developmental process, inflammation, and degenerative diseases. Recently, increasing evidence has shown that ADAM9 plays an important role in tumor biology. Overexpression of ADAM9 has been found in several cancer types and is correlated …
ADAM9 influences the developmental process, inflammation, and degenerative diseases. Recently, increasing evidence has shown that …
The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate primary prostate tumor growth and metastasis.
Chang AC, Lin LW, Chen YC, Chen PC, Liu SC, Tai HC, Wu HC, Sung SY, Lin TH, Tang CH. Chang AC, et al. Int J Biol Sci. 2023 Jan 1;19(3):760-771. doi: 10.7150/ijbs.77495. eCollection 2023. Int J Biol Sci. 2023. PMID: 36778124 Free PMC article.
Elevated levels of WISP-1 expression were detected in the serum of patients with PCa. ADAM9 levels were overexpressed in tumor tissue from PCa patients; ADAM9 blockade interrupted OB-induced release of WISP-1 and also suppressed primary tumor growth and distal metas …
Elevated levels of WISP-1 expression were detected in the serum of patients with PCa. ADAM9 levels were overexpressed in tumor tissue …
Structure, regulatory factors and cancer-related physiological effects of ADAM9.
Haoyuan MA, Yanshu LI. Haoyuan MA, et al. Cell Adh Migr. 2020 Dec;14(1):165-181. doi: 10.1080/19336918.2020.1817251. Cell Adh Migr. 2020. PMID: 32875951 Free PMC article. Review.
These domains have independent but complementary functions that enable them to participate in multiple biological processes. Among them, ADAM9 can not only participate in the degradation of extracellular matrix as a metalloprotease, but also mediate tumor cell adhesion thr …
These domains have independent but complementary functions that enable them to participate in multiple biological processes. Among them, …
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.
Oria VO, Lopatta P, Schmitz T, Preca BT, Nyström A, Conrad C, Bartsch JW, Kulemann B, Hoeppner J, Maurer J, Bronsert P, Schilling O. Oria VO, et al. Mol Oncol. 2019 Feb;13(2):456-479. doi: 10.1002/1878-0261.12426. Epub 2019 Jan 9. Mol Oncol. 2019. PMID: 30556643 Free PMC article.
In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of >100 clinically annotated PDAC cases. We report that ADAM9 is prominently expressed by PDAC tumor cells, and increased ADAM9 …
In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of …
ADAM9: A novel player in vestibular schwannoma pathogenesis.
Breun M, Schwerdtfeger A, Martellotta DD, Kessler AF, Monoranu CM, Matthies C, Löhr M, Hagemann C. Breun M, et al. Oncol Lett. 2020 Mar;19(3):1856-1864. doi: 10.3892/ol.2020.11299. Epub 2020 Jan 14. Oncol Lett. 2020. PMID: 32194680 Free PMC article.
The aim of the present study was to evaluate if ADAM9 could be used as prognostic marker or therapeutic target. ADAM9 mRNA and protein levels were measured in VS samples (n=60). ...Therefore, ADAM9 may be a prognostic marker for VS, and ADAM9 inhibitio …
The aim of the present study was to evaluate if ADAM9 could be used as prognostic marker or therapeutic target. ADAM9 mRNA and …
IL-17A Promotes Epithelial ADAM9 Expression in Cigarette Smoke-Related COPD.
Li D, Wang T, Ma Q, Zhou L, Le Y, Rao Y, Jin L, Pei Y, Cheng Y, Huang C, Gai X, Sun Y. Li D, et al. Int J Chron Obstruct Pulmon Dis. 2022 Oct 14;17:2589-2602. doi: 10.2147/COPD.S375006. eCollection 2022. Int J Chron Obstruct Pulmon Dis. 2022. PMID: 36267325 Free PMC article.
The expression of IL-17A was also upregulated in airway epithelial cells of patients with COPD and correlated positively with the level of ADAM9. The results from the animal model showed that Il17a (-/-) mice were protected from emphysema induced by CS exposure, together w …
The expression of IL-17A was also upregulated in airway epithelial cells of patients with COPD and correlated positively with the level of …
ADAM9 as a potential target molecule in cancer.
Peduto L. Peduto L. Curr Pharm Des. 2009;15(20):2282-7. doi: 10.2174/138161209788682415. Curr Pharm Des. 2009. PMID: 19601830 Review.
ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential therapeutic target in tumors where it is highly expressed. T …
ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie- …
468 results