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TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.
Wu G, Yoshida N, Liu J, Zhang X, Xiong Y, Heavican-Foral TB, Mandato E, Liu H, Nelson GM, Yang L, Chen R, Donovan KA, Jones MK, Roshal M, Zhang Y, Xu R, Nirmal AJ, Jain S, Leahy C, Jones KL, Stevenson KE, Galasso N, Ganesan N, Chang T, Wu WC, Louissaint A, Debaize L, Yoon H, Dal Cin P, Chan WC, Ho Sui SJ, Ng SY, Feldman AL, Horwitz SM, Adelman K, Fischer ES, Chen CW, Weinstock DM, Brown M. Wu G, et al. Among authors: adelman k. Sci Transl Med. 2023 Sep 20;15(714):eadi7244. doi: 10.1126/scitranslmed.adi7244. Epub 2023 Sep 20. Sci Transl Med. 2023. PMID: 37729434 Free PMC article.
Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.
Wheeler EC, Martin BJE, Doyle WC, Neaher S, Conway CA, Pitton CN, Gorelov RA, Donahue M, Jann JC, Abdel-Wahab O, Taylor J, Seiler M, Buonamici S, Pikman Y, Garcia JS, Belizaire R, Adelman K, Tothova Z. Wheeler EC, et al. Among authors: adelman k. Sci Transl Med. 2024 Jan 3;16(728):eade2774. doi: 10.1126/scitranslmed.ade2774. Epub 2024 Jan 3. Sci Transl Med. 2024. PMID: 38170787
Integrator is a global promoter-proximal termination complex.
Wagner EJ, Tong L, Adelman K. Wagner EJ, et al. Among authors: adelman k. Mol Cell. 2023 Feb 2;83(3):416-427. doi: 10.1016/j.molcel.2022.11.012. Epub 2023 Jan 11. Mol Cell. 2023. PMID: 36634676 Free PMC article. Review.
RNA polymerase is poised for activation across the genome.
Muse GW, Gilchrist DA, Nechaev S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. Muse GW, et al. Among authors: adelman k. Nat Genet. 2007 Dec;39(12):1507-11. doi: 10.1038/ng.2007.21. Epub 2007 Nov 11. Nat Genet. 2007. PMID: 17994021 Free PMC article.
101 results