Adelman K - Search Results

1

Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II.

Saha RN, Wissink EM, Bailey ER, Zhao M, Fargo DC, Hwang JY, Daigle KR, Fenn JD, Adelman K, Dudek SM. Saha RN, et al. Among authors: adelman k. Nat Neurosci. 2011 May 29;14(7):848-56. doi: 10.1038/nn.2839. Nat Neurosci. 2011. PMID: 21623364 Free PMC article.

2

TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.

Wu G, Yoshida N, Liu J, Zhang X, Xiong Y, Heavican-Foral TB, Mandato E, Liu H, Nelson GM, Yang L, Chen R, Donovan KA, Jones MK, Roshal M, Zhang Y, Xu R, Nirmal AJ, Jain S, Leahy C, Jones KL, Stevenson KE, Galasso N, Ganesan N, Chang T, Wu WC, Louissaint A, Debaize L, Yoon H, Dal Cin P, Chan WC, Ho Sui SJ, Ng SY, Feldman AL, Horwitz SM, Adelman K, Fischer ES, Chen CW, Weinstock DM, Brown M. Wu G, et al. Among authors: adelman k. Sci Transl Med. 2023 Sep 20;15(714):eadi7244. doi: 10.1126/scitranslmed.adi7244. Epub 2023 Sep 20. Sci Transl Med. 2023. PMID: 37729434 Free PMC article.

3

PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.

Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE. Rambout X, et al. Among authors: adelman k. Mol Cell. 2023 Jan 19;83(2):186-202.e11. doi: 10.1016/j.molcel.2022.12.022. Mol Cell. 2023. PMID: 36669479 Free PMC article.

4

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.

Wheeler EC, Martin BJE, Doyle WC, Neaher S, Conway CA, Pitton CN, Gorelov RA, Donahue M, Jann JC, Abdel-Wahab O, Taylor J, Seiler M, Buonamici S, Pikman Y, Garcia JS, Belizaire R, Adelman K, Tothova Z. Wheeler EC, et al. Among authors: adelman k. Sci Transl Med. 2024 Jan 3;16(728):eade2774. doi: 10.1126/scitranslmed.ade2774. Epub 2024 Jan 3. Sci Transl Med. 2024. PMID: 38170787

5

Oncogenic CDK13 mutations impede nuclear RNA surveillance.

Insco ML, Abraham BJ, Dubbury SJ, Kaltheuner IH, Dust S, Wu C, Chen KY, Liu D, Bellaousov S, Cox AM, Martin BJE, Zhang T, Ludwig CG, Fabo T, Modhurima R, Esgdaille DE, Henriques T, Brown KM, Chanock SJ, Geyer M, Adelman K, Sharp PA, Young RA, Boutz PL, Zon LI. Insco ML, et al. Among authors: adelman k. Science. 2023 Apr 21;380(6642):eabn7625. doi: 10.1126/science.abn7625. Epub 2023 Apr 21. Science. 2023. PMID: 37079685 Free PMC article.

6

RNA polymerase is poised for activation across the genome.

Muse GW, Gilchrist DA, Nechaev S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. Muse GW, et al. Among authors: adelman k. Nat Genet. 2007 Dec;39(12):1507-11. doi: 10.1038/ng.2007.21. Epub 2007 Nov 11. Nat Genet. 2007. PMID: 17994021 Free PMC article.

7

Promoter-proximal Pol II: when stalling speeds things up.

Nechaev S, Adelman K. Nechaev S, et al. Among authors: adelman k. Cell Cycle. 2008 Jun 1;7(11):1539-44. doi: 10.4161/cc.7.11.6006. Epub 2008 Mar 27. Cell Cycle. 2008. PMID: 18469524 Review.

8

NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly.

Gilchrist DA, Nechaev S, Lee C, Ghosh SK, Collins JB, Li L, Gilmour DS, Adelman K. Gilchrist DA, et al. Among authors: adelman k. Genes Dev. 2008 Jul 15;22(14):1921-33. doi: 10.1101/gad.1643208. Genes Dev. 2008. PMID: 18628398 Free PMC article.

9

Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation.

Gilchrist DA, Fargo DC, Adelman K. Gilchrist DA, et al. Among authors: adelman k. Methods. 2009 Aug;48(4):398-408. doi: 10.1016/j.ymeth.2009.02.024. Epub 2009 Mar 9. Methods. 2009. PMID: 19275938 Free PMC article. Review.

10

Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling.

Adelman K, Kennedy MA, Nechaev S, Gilchrist DA, Muse GW, Chinenov Y, Rogatsky I. Adelman K, et al. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18207-12. doi: 10.1073/pnas.0910177106. Epub 2009 Oct 9. Proc Natl Acad Sci U S A. 2009. PMID: 19820169 Free PMC article.

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