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ADHFE1 is a correlative factor of patient survival in cancer.
Chen Q, Wu Q, Peng Y. Chen Q, et al. Open Life Sci. 2021 Jun 18;16(1):571-582. doi: 10.1515/biol-2021-0065. eCollection 2021. Open Life Sci. 2021. PMID: 34179501 Free PMC article.
The role of ADHFE1 in cancer has not been fully uncovered. Herein, we performed data analysis to investigate the expression of ADHFE1 and the underlying regulatory mechanisms, its relationship with cancer patients' survival, and the relevant pathways in cancer. ...H …
The role of ADHFE1 in cancer has not been fully uncovered. Herein, we performed data analysis to investigate the expression of ADH …
Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening.
Li B, Liu S, Gao Y, Zheng L, Lu Y. Li B, et al. J Cancer Res Clin Oncol. 2023 Sep;149(12):10241-10253. doi: 10.1007/s00432-023-04943-4. Epub 2023 Jun 3. J Cancer Res Clin Oncol. 2023. PMID: 37270460
The aim of this study was to investigate the value of combined detection of SDC2, ADHFE1 and PPP2R5C gene methylation in stool samples for early CRC screening. ...Combined detection of SDC2/ADHFE1/PPP2R5C methylation is a potential non-invasive diagnostic method for …
The aim of this study was to investigate the value of combined detection of SDC2, ADHFE1 and PPP2R5C gene methylation in stool sample …
ADHFe1: a novel enzyme involved in retinoic acid-dependent Hox activation.
Shabtai Y, Shukrun N, Fainsod A. Shabtai Y, et al. Int J Dev Biol. 2017;61(3-4-5):303-310. doi: 10.1387/ijdb.160252af. Int J Dev Biol. 2017. PMID: 28621427 Free article.
Gain- and loss-of-function of ADHFe1 were induced to study its function and the regulation of the AdhFe1 gene by RA was studied. ...Manipulation of ADHFe1 levels affects the normal Hox gene expression. The effects of ADHFe1 manipulation can by rescued …
Gain- and loss-of-function of ADHFe1 were induced to study its function and the regulation of the AdhFe1 gene by RA was studie …
ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.
Mishra P, Tang W, Putluri V, Dorsey TH, Jin F, Wang F, Zhu D, Amable L, Deng T, Zhang S, Killian JK, Wang Y, Minas TZ, Yfantis HG, Lee DH, Sreekumar A, Bustin M, Liu W, Putluri N, Ambs S. Mishra P, et al. J Clin Invest. 2018 Jan 2;128(1):323-340. doi: 10.1172/JCI93815. Epub 2017 Nov 27. J Clin Invest. 2018. PMID: 29202474 Free PMC article.
We found that MYC upregulates ADHFE1 through changes in iron metabolism while coexpression of both ADHFE1 and MYC strongly enhanced orthotopic tumor growth in MCF7 cells. ...Together, our data support the hypothesis that ADHFE1 and MYC signaling contribute to …
We found that MYC upregulates ADHFE1 through changes in iron metabolism while coexpression of both ADHFE1 and MYC strongly enh …
Identification of early diagnostic biomarkers via WGCNA in gastric cancer.
Rezaei Z, Ranjbaran J, Safarpour H, Nomiri S, Salmani F, Chamani E, Larki P, Brunetti O, Silvestris N, Tavakoli T. Rezaei Z, et al. Biomed Pharmacother. 2022 Jan;145:112477. doi: 10.1016/j.biopha.2021.112477. Epub 2021 Dec 2. Biomed Pharmacother. 2022. PMID: 34864309 Free article.
RESULTS: The red modules in GSE113255, Turquoise in GSE142000, Brown in GSE118897, and the green-yellow module in GSE130823 datasets were found to be highly correlated with the anatomical site of GC. ITGAX, CCL14, ADHFE1, and HOXB13) as the hub gene are differentially expr …
RESULTS: The red modules in GSE113255, Turquoise in GSE142000, Brown in GSE118897, and the green-yellow module in GSE130823 datasets were fo …
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
Hu YH, Ma S, Zhang XN, Zhang ZY, Zhu HF, Ji YH, Li J, Qian XL, Wang YX. Hu YH, et al. Onco Targets Ther. 2019 Oct 4;12:8105-8115. doi: 10.2147/OTT.S223423. eCollection 2019. Onco Targets Ther. 2019. PMID: 31632063 Free PMC article.
However, the role and mechanism of ADHFE1 in the proliferation of CRC remain unclear. MATERIALS AND METHODS: ADHFE1 expression was analyzed in CRC tissues by IHC and qRT-PCR, and the relationship between ADHFE1 expression and the clinicopathological parameter …
However, the role and mechanism of ADHFE1 in the proliferation of CRC remain unclear. MATERIALS AND METHODS: ADHFE1 expression …
ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer.
Mishra P, Tang W, Ambs S. Mishra P, et al. Mol Cell Oncol. 2018 Apr 19;5(3):e1432260. doi: 10.1080/23723556.2018.1432260. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250890 Free PMC article.
It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis....
It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-di …
Differentiation-dependent expression of Adhfe1 in adipogenesis.
Kim JY, Tillison KS, Zhou S, Lee JH, Smas CM. Kim JY, et al. Arch Biochem Biophys. 2007 Aug 1;464(1):100-11. doi: 10.1016/j.abb.2007.04.018. Epub 2007 May 7. Arch Biochem Biophys. 2007. PMID: 17559793 Free PMC article.
We have determined that adipocytes are a major site of expression of the transcript for the novel alcohol dehydrogenase (ADH), Adhfe1. Adhfe1 is unique in that the sequence of its encoded protein places it among the iron-activated ADHs. ...Adhfe1 transcript e …
We have determined that adipocytes are a major site of expression of the transcript for the novel alcohol dehydrogenase (ADH), Adhfe1 …
Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells.
Moon JW, Lee SK, Lee YW, Lee JO, Kim N, Lee HJ, Seo JS, Kim J, Kim HS, Park SH. Moon JW, et al. BMC Cancer. 2014 May 28;14:377. doi: 10.1186/1471-2407-14-377. BMC Cancer. 2014. PMID: 24886599 Free PMC article.
RESULTS: ADHFE1 was hypermethylated in 69 of 73 CRC tissues (95%) compared to adjacent normal tissues (p<0.05). ...CONCLUSION: These results demonstrate that the promoter hypermethylation of ADHFE1 is frequently present in CRC and alcohol induces methylation-medi …
RESULTS: ADHFE1 was hypermethylated in 69 of 73 CRC tissues (95%) compared to adjacent normal tissues (p<0.05). ...CONCLUSION: The …
Genome-wide DNA methylation profiling of gastric cardia cancer.
Lin R, Qian Y, Zhang J, Xia D, Guo D, Hong L, Qing B, Xu M, Huang Y, Lin W, Chen G, Liu S. Lin R, et al. J Gastroenterol Hepatol. 2023 Feb;38(2):290-300. doi: 10.1111/jgh.16054. Epub 2022 Nov 29. J Gastroenterol Hepatol. 2023. PMID: 36342849
Differential methylation analysis identified a total of 91 723 differentially-methylated probes (DMPs), and the candidate gene with the largest average DNA methylation difference mapped to ADHFE1 (mean deltabeta = 0.53). Subsequently, three DMPs in the ADHFE1 promot …
Differential methylation analysis identified a total of 91 723 differentially-methylated probes (DMPs), and the candidate gene with the larg …
41 results