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Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.
Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Xu H, et al. Among authors: adler as. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4228-4233. doi: 10.1073/pnas.1718414115. Epub 2018 Apr 2. Proc Natl Acad Sci U S A. 2018. PMID: 29610318 Free PMC article.
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1.
Tsai PY, Lee MS, Jadhav U, Naqvi I, Madha S, Adler A, Mistry M, Naumenko S, Lewis CA, Hitchcock DS, Roberts FR, DelNero P, Hank T, Honselmann KC, Morales Oyarvide V, Mino-Kenudson M, Clish CB, Shivdasani RA, Kalaany NY. Tsai PY, et al. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2003014118. doi: 10.1073/pnas.2003014118. Proc Natl Acad Sci U S A. 2021. PMID: 33653947 Free PMC article.
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer.
Lee MS, Dennis C, Naqvi I, Dailey L, Lorzadeh A, Ye G, Zaytouni T, Adler A, Hitchcock DS, Lin L, Hoffman MT, Bhuiyan AM, Barth JL, Machacek ME, Mino-Kenudson M, Dougan SK, Jadhav U, Clish CB, Kalaany NY. Lee MS, et al. Nature. 2023 Apr;616(7956):339-347. doi: 10.1038/s41586-023-05891-2. Epub 2023 Mar 29. Nature. 2023. PMID: 36991126 Free PMC article.
A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern.
Wayham NP, Niedecken AR, Simons JF, Chiang YY, Medina-Cucurella AV, Mizrahi RA, Wagner EK, Gras A, Segal I, Witte P, Enstrom A, Bountouvas A, Nelson SM, Weinberger T, Tan D, Asensio MA, Subramanian A, Lim YW, Adler AS, Keating SM. Wayham NP, et al. Among authors: adler as. J Infect Dis. 2023 Aug 31;228(5):555-563. doi: 10.1093/infdis/jiad102. J Infect Dis. 2023. PMID: 37062677 Free PMC article.
GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2.
Mizrahi RA, Lin WY, Gras A, Niedecken AR, Wagner EK, Keating SM, Ikon N, Manickam VA, Asensio MA, Leong J, Medina-Cucurella AV, Benzie E, Carter KP, Chiang Y, Edgar RC, Leong R, Lim YW, Simons JF, Spindler MJ, Stadtmiller K, Wayham N, Büscher D, Terencio JV, Germanio CD, Chamow SM, Olson C, Pino PA, Park JG, Hicks A, Ye C, Garcia-Vilanova A, Martinez-Sobrido L, Torrelles JB, Johnson DS, Adler AS. Mizrahi RA, et al. Among authors: adler as. Pathogens. 2022 Jul 19;11(7):806. doi: 10.3390/pathogens11070806. Pathogens. 2022. PMID: 35890050 Free PMC article.
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