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Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance.
Mol Oncol. 2021 Dec;15(12):3256-3279. doi: 10.1002/1878-0261.13063. Epub 2021 Jul 29.
Mol Oncol. 2021.
PMID: 34289244
Free PMC article.
Review.
Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis.
Afsar SY, Alam S, Fernandez Gonzalez C, van Echten-Deckert G.
Afsar SY, et al.
Mol Oncol. 2022 Oct;16(20):3642-3653. doi: 10.1002/1878-0261.13300. Epub 2022 Aug 16.
Mol Oncol. 2022.
PMID: 35973936
Free PMC article.
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S1P Released by SGPL1-Deficient Astrocytes Enhances Astrocytic ATP Production via S1PR2,4, Thus Keeping Autophagy in Check: Potential Consequences for Brain Health.
Alam S, Afsar SY, Van Echten-Deckert G.
Alam S, et al. Among authors: afsar sy.
Int J Mol Sci. 2023 Feb 26;24(5):4581. doi: 10.3390/ijms24054581.
Int J Mol Sci. 2023.
PMID: 36902011
Free PMC article.
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S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling.
Alam S, Afsar SY, Wolter MA, Volk LM, Mitroi DN, Meyer Zu Heringdorf D, van Echten-Deckert G.
Alam S, et al. Among authors: afsar sy.
Cells. 2023 Jul 13;12(14):1844. doi: 10.3390/cells12141844.
Cells. 2023.
PMID: 37508508
Free PMC article.
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Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells.
Wollnitzke P, Wagner R, Afsar SY, Werner M, Geschold R, Müller CE, Werz O, van Echten-Deckert G, Menche D.
Wollnitzke P, et al. Among authors: afsar sy.
Bioorg Med Chem Lett. 2023 Oct 1;94:129464. doi: 10.1016/j.bmcl.2023.129464. Epub 2023 Aug 25.
Bioorg Med Chem Lett. 2023.
PMID: 37634760
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