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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 4
2006 14
2007 22
2008 24
2009 27
2010 27
2011 30
2012 24
2013 20
2014 22
2015 22
2016 19
2017 16
2018 11
2019 24
2020 27
2021 28
2022 25
2023 40
2024 11

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Cross-platform proteomics signatures of extreme old age.
Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Reed ER, et al. bioRxiv [Preprint]. 2024 Apr 14:2024.04.10.588876. doi: 10.1101/2024.04.10.588876. bioRxiv. 2024. PMID: 38645061 Free PMC article. Preprint.
Learning Gaussian Graphical Models from Correlated Data.
Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Song Z, et al. bioRxiv [Preprint]. 2024 Apr 5:2024.04.03.587948. doi: 10.1101/2024.04.03.587948. bioRxiv. 2024. PMID: 38617340 Free PMC article. Preprint.
The 2023 Report on the Proteome from the HUPO Human Proteome Project.
Omenn GS, Lane L, Overall CM, Lindskog C, Pineau C, Packer NH, Cristea IM, Weintraub ST, Orchard S, Roehrl MHA, Nice E, Guo T, Van Eyk JE, Liu S, Bandeira N, Aebersold R, Moritz RL, Deutsch EW. Omenn GS, et al. J Proteome Res. 2024 Feb 2;23(2):532-549. doi: 10.1021/acs.jproteome.3c00591. Epub 2024 Jan 17. J Proteome Res. 2024. PMID: 38232391 Free PMC article. Review.
Population genomics of post-glacial western Eurasia.
Allentoft ME, Sikora M, Refoyo-Martínez A, Irving-Pease EK, Fischer A, Barrie W, Ingason A, Stenderup J, Sjögren KG, Pearson A, Sousa da Mota B, Schulz Paulsson B, Halgren A, Macleod R, Jørkov MLS, Demeter F, Sørensen L, Nielsen PO, Henriksen RA, Vimala T, McColl H, Margaryan A, Ilardo M, Vaughn A, Fischer Mortensen M, Nielsen AB, Ulfeldt Hede M, Johannsen NN, Rasmussen P, Vinner L, Renaud G, Stern A, Jensen TZT, Scorrano G, Schroeder H, Lysdahl P, Ramsøe AD, Skorobogatov A, Schork AJ, Rosengren A, Ruter A, Outram A, Timoshenko AA, Buzhilova A, Coppa A, Zubova A, Silva AM, Hansen AJ, Gromov A, Logvin A, Gotfredsen AB, Henning Nielsen B, González-Rabanal B, Lalueza-Fox C, McKenzie CJ, Gaunitz C, Blasco C, Liesau C, Martinez-Labarga C, Pozdnyakov DV, Cuenca-Solana D, Lordkipanidze DO, En'shin D, Salazar-García DC, Price TD, Borić D, Kostyleva E, Veselovskaya EV, Usmanova ER, Cappellini E, Brinch Petersen E, Kannegaard E, Radina F, Eylem Yediay F, Duday H, Gutiérrez-Zugasti I, Merts I, Potekhina I, Shevnina I, Altinkaya I, Guilaine J, Hansen J, Aura Tortosa JE, Zilhão J, Vega J, Buck Pedersen K, Tunia K, Zhao L, Mylnikova LN, Larsson L, Metz L, Yepiskoposyan L, Pedersen L, Sarti L, O… See abstract for full author list ➔ Allentoft ME, et al. Nature. 2024 Jan;625(7994):301-311. doi: 10.1038/s41586-023-06865-0. Epub 2024 Jan 10. Nature. 2024. PMID: 38200295 Free PMC article.
100 ancient genomes show repeated population turnovers in Neolithic Denmark.
Allentoft ME, Sikora M, Fischer A, Sjögren KG, Ingason A, Macleod R, Rosengren A, Schulz Paulsson B, Jørkov MLS, Novosolov M, Stenderup J, Price TD, Fischer Mortensen M, Nielsen AB, Ulfeldt Hede M, Sørensen L, Nielsen PO, Rasmussen P, Jensen TZT, Refoyo-Martínez A, Irving-Pease EK, Barrie W, Pearson A, Sousa da Mota B, Demeter F, Henriksen RA, Vimala T, McColl H, Vaughn A, Vinner L, Renaud G, Stern A, Johannsen NN, Ramsøe AD, Schork AJ, Ruter A, Gotfredsen AB, Henning Nielsen B, Brinch Petersen E, Kannegaard E, Hansen J, Buck Pedersen K, Pedersen L, Klassen L, Meldgaard M, Johansen M, Uldum OC, Lotz P, Lysdahl P, Bangsgaard P, Petersen PV, Maring R, Iversen R, Wåhlin S, Anker Sørensen S, Andersen SH, Jørgensen T, Lynnerup N, Lawson DJ, Rasmussen S, Korneliussen TS, Kjær KH, Durbin R, Nielsen R, Delaneau O, Werge T, Kristiansen K, Willerslev E. Allentoft ME, et al. Nature. 2024 Jan;625(7994):329-337. doi: 10.1038/s41586-023-06862-3. Epub 2024 Jan 10. Nature. 2024. PMID: 38200294 Free PMC article.
Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA).
Day NJ, Kelly SS, Lui LY, Mansfield TA, Gaffrey MJ, Trejo JB, Sagendorf TJ, Attah K, Moore RJ, Douglas CM, Newman AB, Kritchevsky SB, Kramer PA, Marcinek DJ, Coen PM, Goodpaster BH, Hepple RT, Cawthon PM, Petyuk VA, Esser KA, Qian WJ, Cummings SR. Day NJ, et al. medRxiv [Preprint]. 2023 Nov 8:2023.11.07.23298224. doi: 10.1101/2023.11.07.23298224. medRxiv. 2023. PMID: 37986748 Free PMC article. Updated. Preprint.
Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers.
Watanabe K, Wilmanski T, Baloni P, Robinson M, Garcia GG, Hoopmann MR, Midha MK, Baxter DH, Maes M, Morrone SR, Crebs KM, Kapil C, Kusebauch U, Wiedrick J, Lapidus J, Pflieger L, Lausted C, Roach JC, Glusman G, Cummings SR, Schork NJ, Price ND, Hood L, Miller RA, Moritz RL, Rappaport N. Watanabe K, et al. Commun Biol. 2023 Jul 22;6(1):768. doi: 10.1038/s42003-023-05128-y. Commun Biol. 2023. PMID: 37481675 Free PMC article.
Exploring human biology with N-of-1 clinical trials.
Schork NJ, Beaulieu-Jones B, Liang WS, Smalley S, Goetz LH. Schork NJ, et al. Camb Prism Precis Med. 2023;1:e12. doi: 10.1017/pcm.2022.15. Epub 2023 Jan 10. Camb Prism Precis Med. 2023. PMID: 37255593 Free PMC article.
Human metabolome variation along the upper intestinal tract.
Folz J, Culver RN, Morales JM, Grembi J, Triadafilopoulos G, Relman DA, Huang KC, Shalon D, Fiehn O. Folz J, et al. Nat Metab. 2023 May;5(5):777-788. doi: 10.1038/s42255-023-00777-z. Epub 2023 May 10. Nat Metab. 2023. PMID: 37165176 Free PMC article.
Mosaic Chromosomal Alterations and Human Longevity.
Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Leshchyk A, et al. J Gerontol A Biol Sci Med Sci. 2023 Aug 27;78(9):1561-1568. doi: 10.1093/gerona/glad095. J Gerontol A Biol Sci Med Sci. 2023. PMID: 36988570 Free PMC article.
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann CL, Schulz JF, Ruiz-Orera J, Kirchner M, Ziehm M, Adami E, Marczenke M, Christ A, Liebe N, Greiner J, Schoenenberger A, Muecke MB, Liang N, Moritz RL, Sun Z, Deutsch EW, Gotthardt M, Mudge JM, Prensner JR, Willnow TE, Mertins P, van Heesch S, Hubner N. Sandmann CL, et al. Mol Cell. 2023 Mar 16;83(6):994-1011.e18. doi: 10.1016/j.molcel.2023.01.023. Epub 2023 Feb 17. Mol Cell. 2023. PMID: 36806354 Free PMC article.
Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work.
Deutsch EW, Vizcaíno JA, Jones AR, Binz PA, Lam H, Klein J, Bittremieux W, Perez-Riverol Y, Tabb DL, Walzer M, Ricard-Blum S, Hermjakob H, Neumann S, Mak TD, Kawano S, Mendoza L, Van Den Bossche T, Gabriels R, Bandeira N, Carver J, Pullman B, Sun Z, Hoffmann N, Shofstahl J, Zhu Y, Licata L, Quaglia F, Tosatto SCE, Orchard SE. Deutsch EW, et al. J Proteome Res. 2023 Feb 3;22(2):287-301. doi: 10.1021/acs.jproteome.2c00637. Epub 2023 Jan 10. J Proteome Res. 2023. PMID: 36626722 Free PMC article. Review.
A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.
Bae H, Gurinovich A, Karagiannis TT, Song Z, Leshchyk A, Li M, Andersen SL, Arbeev K, Yashin A, Zmuda J, An P, Feitosa M, Giuliani C, Franceschi C, Garagnani P, Mengel-From J, Atzmon G, Barzilai N, Puca A, Schork NJ, Perls TT, Sebastiani P. Bae H, et al. Int J Mol Sci. 2022 Dec 21;24(1):116. doi: 10.3390/ijms24010116. Int J Mol Sci. 2022. PMID: 36613555 Free PMC article.
The Crux Toolkit for Analysis of Bottom-Up Tandem Mass Spectrometry Proteomics Data.
Kertesz-Farkas A, Nii Adoquaye Acquaye FL, Bhimani K, Eng JK, Fondrie WE, Grant C, Hoopmann MR, Lin A, Lu YY, Moritz RL, MacCoss MJ, Noble WS. Kertesz-Farkas A, et al. J Proteome Res. 2023 Feb 3;22(2):561-569. doi: 10.1021/acs.jproteome.2c00615. Epub 2023 Jan 4. J Proteome Res. 2023. PMID: 36598107 Free PMC article.
The ProteomeXchange consortium at 10 years: 2023 update.
Deutsch EW, Bandeira N, Perez-Riverol Y, Sharma V, Carver JJ, Mendoza L, Kundu DJ, Wang S, Bandla C, Kamatchinathan S, Hewapathirana S, Pullman BS, Wertz J, Sun Z, Kawano S, Okuda S, Watanabe Y, MacLean B, MacCoss MJ, Zhu Y, Ishihama Y, Vizcaíno JA. Deutsch EW, et al. Nucleic Acids Res. 2023 Jan 6;51(D1):D1539-D1548. doi: 10.1093/nar/gkac1040. Nucleic Acids Res. 2023. PMID: 36370099 Free PMC article.
The 2022 Report on the Human Proteome from the HUPO Human Proteome Project.
Omenn GS, Lane L, Overall CM, Pineau C, Packer NH, Cristea IM, Lindskog C, Weintraub ST, Orchard S, Roehrl MHA, Nice E, Liu S, Bandeira N, Chen YJ, Guo T, Aebersold R, Moritz RL, Deutsch EW. Omenn GS, et al. J Proteome Res. 2023 Apr 7;22(4):1024-1042. doi: 10.1021/acs.jproteome.2c00498. Epub 2022 Nov 1. J Proteome Res. 2023. PMID: 36318223 Free PMC article. Review.
A metabolomic signature of the APOE2 allele.
Sebastiani P, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Lustgarten MS, Funk CC, Baloni P, Yao CH, Joshi S, Marron MM, Gurinovich A, Li M, Leshchyk A, Xiang Q, Andersen SL, Feitosa MF, Ukraintseva S, Soerensen M, Fiehn O, Ordovas JM, Haigis M, Monti S, Barzilai N, Milman S, Ferrucci L, Rappaport N, Patti GJ, Perls TT. Sebastiani P, et al. Geroscience. 2023 Feb;45(1):415-426. doi: 10.1007/s11357-022-00646-9. Epub 2022 Aug 23. Geroscience. 2023. PMID: 35997888 Free PMC article.
Standardized annotation of translated open reading frames.
Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S. Mudge JM, et al. Nat Biotechnol. 2022 Jul;40(7):994-999. doi: 10.1038/s41587-022-01369-0. Nat Biotechnol. 2022. PMID: 35831657 Free PMC article. No abstract available.
Engineered SH2 Domains for Targeted Phosphoproteomics.
Martyn GD, Veggiani G, Kusebauch U, Morrone SR, Yates BP, Singer AU, Tong J, Manczyk N, Gish G, Sun Z, Kurinov I, Sicheri F, Moran MF, Moritz RL, Sidhu SS. Martyn GD, et al. ACS Chem Biol. 2022 Jun 17;17(6):1472-1484. doi: 10.1021/acschembio.2c00051. Epub 2022 May 25. ACS Chem Biol. 2022. PMID: 35613471 Free PMC article.
Does Modulation of an Epigenetic Clock Define a Geroprotector?
Schork NJ, Beaulieu-Jones B, Liang W, Smalley S, Goetz LH. Schork NJ, et al. Adv Geriatr Med Res. 2022;4(1):e220002. doi: 10.20900/agmr20220002. Epub 2022 Mar 29. Adv Geriatr Med Res. 2022. PMID: 35466328 Free PMC article.
Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.
Heath L, Earls JC, Magis AT, Kornilov SA, Lovejoy JC, Funk CC, Rappaport N, Logsdon BA, Mangravite LM, Kunkle BW, Martin ER, Naj AC, Ertekin-Taner N, Golde TE, Hood L, Price ND; Alzheimer’s Disease Genetics Consortium. Heath L, et al. Sci Rep. 2022 Apr 12;12(1):6117. doi: 10.1038/s41598-022-09825-2. Sci Rep. 2022. PMID: 35413975 Free PMC article.
Proteomics Standards Initiative's ProForma 2.0: Unifying the Encoding of Proteoforms and Peptidoforms.
LeDuc RD, Deutsch EW, Binz PA, Fellers RT, Cesnik AJ, Klein JA, Van Den Bossche T, Gabriels R, Yalavarthi A, Perez-Riverol Y, Carver J, Bittremieux W, Kawano S, Pullman B, Bandeira N, Kelleher NL, Thomas PM, Vizcaíno JA. LeDuc RD, et al. J Proteome Res. 2022 Apr 1;21(4):1189-1195. doi: 10.1021/acs.jproteome.1c00771. Epub 2022 Mar 15. J Proteome Res. 2022. PMID: 35290070 Free PMC article.
Factor analysis to determine relative contributions of strength, physical performance, body composition and muscle mass to disability and mobility disability outcomes in older men.
Zanker J, Blackwell T, Patel S, Duchowny K, Brennan-Olsen S, Cummings SR, Evans WJ, Orwoll ES, Scott D, Vogrin S, Duque G, Cawthon PM; Osteoporotic Fractures in Men (MrOS) Study Group. Zanker J, et al. Exp Gerontol. 2022 May;161:111714. doi: 10.1016/j.exger.2022.111714. Epub 2022 Jan 29. Exp Gerontol. 2022. PMID: 35104566 Free PMC article.
Mouse Organ-Specific Proteins and Functions.
Sun B, Lorang C, Qin S, Zhang Y, Liu K, Li G, Sun Z, Francke A, Utleg AG, Hu Z, Wang K, Moritz RL, Hood L. Sun B, et al. Cells. 2021 Dec 8;10(12):3449. doi: 10.3390/cells10123449. Cells. 2021. PMID: 34943957 Free PMC article.
Molecular Damage in Aging.
Gladyshev VN, Kritchevsky SB, Clarke SG, Cuervo AM, Fiehn O, de Magalhães JP, Mau T, Maes M, Moritz R, Niedernhofer LJ, Van Schaftingen E, Tranah GJ, Walsh K, Yura Y, Zhang B, Cummings SR. Gladyshev VN, et al. Nat Aging. 2021 Dec;1(12):1096-1106. doi: 10.1038/s43587-021-00150-3. Epub 2021 Dec 20. Nat Aging. 2021. PMID: 36846190 Free PMC article. Review.
Advances and Utility of the Human Plasma Proteome.
Deutsch EW, Omenn GS, Sun Z, Maes M, Pernemalm M, Palaniappan KK, Letunica N, Vandenbrouck Y, Brun V, Tao SC, Yu X, Geyer PE, Ignjatovic V, Moritz RL, Schwenk JM. Deutsch EW, et al. J Proteome Res. 2021 Dec 3;20(12):5241-5263. doi: 10.1021/acs.jproteome.1c00657. Epub 2021 Oct 21. J Proteome Res. 2021. PMID: 34672606 Free PMC article. Review.
Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.
Omenn GS, Lane L, Overall CM, Paik YK, Cristea IM, Corrales FJ, Lindskog C, Weintraub S, Roehrl MHA, Liu S, Bandeira N, Srivastava S, Chen YJ, Aebersold R, Moritz RL, Deutsch EW. Omenn GS, et al. J Proteome Res. 2021 Dec 3;20(12):5227-5240. doi: 10.1021/acs.jproteome.1c00590. Epub 2021 Oct 20. J Proteome Res. 2021. PMID: 34670092 Free PMC article.
A metabolome atlas of the aging mouse brain.
Ding J, Ji J, Rabow Z, Shen T, Folz J, Brydges CR, Fan S, Lu X, Mehta S, Showalter MR, Zhang Y, Araiza R, Bower LR, Lloyd KCK, Fiehn O. Ding J, et al. Nat Commun. 2021 Oct 15;12(1):6021. doi: 10.1038/s41467-021-26310-y. Nat Commun. 2021. PMID: 34654818 Free PMC article.
Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.
Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM. Mikacenic C, et al. Crit Care Med. 2022 Mar 1;50(3):e284-e293. doi: 10.1097/CCM.0000000000005333. Crit Care Med. 2022. PMID: 34593707 Free PMC article.
Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance.
Talboom JS, De Both MD, Naymik MA, Schmidt AM, Lewis CR, Jepsen WM, Håberg AK, Rundek T, Levin BE, Hoscheidt S, Bolla Y, Brinton RD, Schork NJ, Hay M, Barnes CA, Glisky E, Ryan L, Huentelman MJ. Talboom JS, et al. NPJ Aging Mech Dis. 2021 Jul 1;7(1):14. doi: 10.1038/s41514-021-00067-6. NPJ Aging Mech Dis. 2021. PMID: 34210964 Free PMC article.
Improved methods for RNAseq-based alternative splicing analysis.
Halperin RF, Hegde A, Lang JD, Raupach EA; C4RCD Research Group; Legendre C, Liang WS, LoRusso PM, Sekulic A, Sosman JA, Trent JM, Rangasamy S, Pirrotte P, Schork NJ. Halperin RF, et al. Sci Rep. 2021 May 24;11(1):10740. doi: 10.1038/s41598-021-89938-2. Sci Rep. 2021. PMID: 34031440 Free PMC article.
Effect of longevity genetic variants on the molecular aging rate.
Gurinovich A, Song Z, Zhang W, Federico A, Monti S, Andersen SL, Jennings LL, Glass DJ, Barzilai N, Millman S, Perls TT, Sebastiani P. Gurinovich A, et al. Geroscience. 2021 Jun;43(3):1237-1251. doi: 10.1007/s11357-021-00376-4. Epub 2021 May 4. Geroscience. 2021. PMID: 33948810 Free PMC article.
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.
Russell RM, Bibollet-Ruche F, Liu W, Sherrill-Mix S, Li Y, Connell J, Loy DE, Trimboli S, Smith AG, Avitto AN, Gondim MVP, Plenderleith LJ, Wetzel KS, Collman RG, Ayouba A, Esteban A, Peeters M, Kohler WJ, Miller RA, François-Souquiere S, Switzer WM, Hirsch VM, Marx PA, Piel AK, Stewart FA, Georgiev AV, Sommer V, Bertolani P, Hart JA, Hart TB, Shaw GM, Sharp PM, Hahn BH. Russell RM, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2025914118. doi: 10.1073/pnas.2025914118. Proc Natl Acad Sci U S A. 2021. PMID: 33771926 Free PMC article.
Author Correction: Gut microbiome pattern reflects healthy ageing and predicts survival in humans.
Wilmanski T, Diener C, Rappaport N, Patwardhan S, Wiedrick J, Lapidus J, Earls JC, Zimmer A, Glusman G, Robinson M, Yurkovich JT, Kado DM, Cauley JA, Zmuda J, Lane NE, Magis AT, Lovejoy JC, Hood L, Gibbons SM, Orwoll ES, Price ND. Wilmanski T, et al. Nat Metab. 2021 Apr;3(4):586. doi: 10.1038/s42255-021-00377-9. Nat Metab. 2021. PMID: 33731896 Free PMC article. No abstract available.
Gut microbiome pattern reflects healthy ageing and predicts survival in humans.
Wilmanski T, Diener C, Rappaport N, Patwardhan S, Wiedrick J, Lapidus J, Earls JC, Zimmer A, Glusman G, Robinson M, Yurkovich JT, Kado DM, Cauley JA, Zmuda J, Lane NE, Magis AT, Lovejoy JC, Hood L, Gibbons SM, Orwoll ES, Price ND. Wilmanski T, et al. Nat Metab. 2021 Feb;3(2):274-286. doi: 10.1038/s42255-021-00348-0. Epub 2021 Feb 18. Nat Metab. 2021. PMID: 33619379 Free PMC article.
Contextualized Protein-Protein Interactions.
Federico A, Monti S. Federico A, et al. Patterns (N Y). 2020 Nov 20;2(1):100153. doi: 10.1016/j.patter.2020.100153. eCollection 2021 Jan 8. Patterns (N Y). 2020. PMID: 33511361 Free PMC article.
A non-hallucinogenic psychedelic analogue with therapeutic potential.
Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. Cameron LP, et al. Nature. 2021 Jan;589(7842):474-479. doi: 10.1038/s41586-020-3008-z. Epub 2020 Dec 9. Nature. 2021. PMID: 33299186 Free PMC article.
Proteomic assessment of serum biomarkers of longevity in older men.
Orwoll ES, Wiedrick J, Nielson CM, Jacobs J, Baker ES, Piehowski P, Petyuk V, Gao Y, Shi T, Smith RD, Bauer DC, Cummings SR, Lapidus J; Osteoporotic Fractures in Men Study (MrOS) Research Group. Orwoll ES, et al. Aging Cell. 2020 Nov;19(11):e13253. doi: 10.1111/acel.13253. Epub 2020 Oct 20. Aging Cell. 2020. PMID: 33078901 Free PMC article.
A high-stringency blueprint of the human proteome.
Adhikari S, Nice EC, Deutsch EW, Lane L, Omenn GS, Pennington SR, Paik YK, Overall CM, Corrales FJ, Cristea IM, Van Eyk JE, Uhlén M, Lindskog C, Chan DW, Bairoch A, Waddington JC, Justice JL, LaBaer J, Rodriguez H, He F, Kostrzewa M, Ping P, Gundry RL, Stewart P, Srivastava S, Srivastava S, Nogueira FCS, Domont GB, Vandenbrouck Y, Lam MPY, Wennersten S, Vizcaino JA, Wilkins M, Schwenk JM, Lundberg E, Bandeira N, Marko-Varga G, Weintraub ST, Pineau C, Kusebauch U, Moritz RL, Ahn SB, Palmblad M, Snyder MP, Aebersold R, Baker MS. Adhikari S, et al. Nat Commun. 2020 Oct 16;11(1):5301. doi: 10.1038/s41467-020-19045-9. Nat Commun. 2020. PMID: 33067450 Free PMC article. Review.
Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project.
Omenn GS, Lane L, Overall CM, Cristea IM, Corrales FJ, Lindskog C, Paik YK, Van Eyk JE, Liu S, Pennington SR, Snyder MP, Baker MS, Bandeira N, Aebersold R, Moritz RL, Deutsch EW. Omenn GS, et al. J Proteome Res. 2020 Dec 4;19(12):4735-4746. doi: 10.1021/acs.jproteome.0c00485. Epub 2020 Oct 19. J Proteome Res. 2020. PMID: 32931287 Free PMC article.
Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0.
Deutsch EW, Lane L, Overall CM, Bandeira N, Baker MS, Pineau C, Moritz RL, Corrales F, Orchard S, Van Eyk JE, Paik YK, Weintraub ST, Vandenbrouck Y, Omenn GS. Deutsch EW, et al. J Proteome Res. 2019 Dec 6;18(12):4108-4116. doi: 10.1021/acs.jproteome.9b00542. Epub 2019 Oct 21. J Proteome Res. 2019. PMID: 31599596 Free PMC article.
Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology.
Barupal DK, Baillie R, Fan S, Saykin AJ, Meikle PJ, Arnold M, Nho K, Fiehn O, Kaddurah-Daouk R; Alzheimer Disease Metabolomics Consortium. Barupal DK, et al. Alzheimers Dement (Amst). 2019 Sep 5;11:619-627. doi: 10.1016/j.dadm.2019.07.002. eCollection 2019 Dec. Alzheimers Dement (Amst). 2019. PMID: 31517024 Free PMC article.
hypeR: an R package for geneset enrichment workflows.
Federico A, Monti S. Federico A, et al. Bioinformatics. 2020 Feb 15;36(4):1307-1308. doi: 10.1093/bioinformatics/btz700. Bioinformatics. 2020. PMID: 31498385 Free PMC article.
A serum protein signature of APOE genotypes in centenarians.
Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT. Sebastiani P, et al. Aging Cell. 2019 Dec;18(6):e13023. doi: 10.1111/acel.13023. Epub 2019 Aug 5. Aging Cell. 2019. PMID: 31385390 Free PMC article.
The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE).
Wolters FJ, Yang Q, Biggs ML, Jakobsdottir J, Li S, Evans DS, Bis JC, Harris TB, Vasan RS, Zilhao NR, Ghanbari M, Ikram MA, Launer L, Psaty BM, Tranah GJ, Kulminski AM, Gudnason V, Seshadri S; E2-CHARGE investigators. Wolters FJ, et al. PLoS One. 2019 Jul 29;14(7):e0219668. doi: 10.1371/journal.pone.0219668. eCollection 2019. PLoS One. 2019. PMID: 31356640 Free PMC article.
Genetic associations with age of menopause in familial longevity.
Bae H, Lunetta KL, Murabito JM, Andersen SL, Schupf N, Perls T, Sebastiani P; Long Life Family Study. Bae H, et al. Menopause. 2019 Oct;26(10):1204-1212. doi: 10.1097/GME.0000000000001367. Menopause. 2019. PMID: 31188284 Free PMC article.
Proteomics Standards Initiative Extended FASTA Format.
Binz PA, Shofstahl J, Vizcaíno JA, Barsnes H, Chalkley RJ, Menschaert G, Alpi E, Clauser K, Eng JK, Lane L, Seymour SL, Sánchez LFH, Mayer G, Eisenacher M, Perez-Riverol Y, Kapp EA, Mendoza L, Baker PR, Collins A, Van Den Bossche T, Deutsch EW. Binz PA, et al. J Proteome Res. 2019 Jun 7;18(6):2686-2692. doi: 10.1021/acs.jproteome.9b00064. Epub 2019 May 23. J Proteome Res. 2019. PMID: 31081335 Free PMC article.
Cellular energetics and mitochondrial uncoupling in canine aging.
Nicholatos JW, Robinette TM, Tata SVP, Yordy JD, Francisco AB, Platov M, Yeh TK, Ilkayeva OR, Huynh FK, Dokukin M, Volkov D, Weinstein MA, Boyko AR, Miller RA, Sokolov I, Hirschey MD, Libert S. Nicholatos JW, et al. Geroscience. 2019 Apr;41(2):229-242. doi: 10.1007/s11357-019-00062-6. Epub 2019 Apr 1. Geroscience. 2019. PMID: 30937823 Free PMC article.
APOE Alleles and Extreme Human Longevity.
Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. Sebastiani P, et al. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51. doi: 10.1093/gerona/gly174. J Gerontol A Biol Sci Med Sci. 2019. PMID: 30060062 Free PMC article. Review.
Comparison of phasing strategies for whole human genomes.
Choi Y, Chan AP, Kirkness E, Telenti A, Schork NJ. Choi Y, et al. PLoS Genet. 2018 Apr 5;14(4):e1007308. doi: 10.1371/journal.pgen.1007308. eCollection 2018 Apr. PLoS Genet. 2018. PMID: 29621242 Free PMC article.
Purpose in Life Among Centenarian Offspring.
Marone S, Bloore K, Sebastiani P, Flynn C, Leonard B, Whitaker K, Mostowy M, Perls TT, Andersen SL. Marone S, et al. J Gerontol B Psychol Sci Soc Sci. 2020 Jan 14;75(2):308-315. doi: 10.1093/geronb/gby023. J Gerontol B Psychol Sci Soc Sci. 2020. PMID: 29522128 Free PMC article.
Regulation of FOXO Factors in Mammalian Cells.
Brown AK, Webb AE. Brown AK, et al. Curr Top Dev Biol. 2018;127:165-192. doi: 10.1016/bs.ctdb.2017.10.006. Epub 2017 Nov 15. Curr Top Dev Biol. 2018. PMID: 29433737 Free PMC article. Review.
Assortative Mating by Ethnicity in Longevous Families.
Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT. Sebastiani P, et al. Front Genet. 2017 Nov 21;8:186. doi: 10.3389/fgene.2017.00186. eCollection 2017. Front Genet. 2017. PMID: 29209360 Free PMC article.
The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature.
Ben-Avraham D, Govindaraju DR, Budagov T, Fradin D, Durda P, Liu B, Ott S, Gutman D, Sharvit L, Kaplan R, Bougnères P, Reiner A, Shuldiner AR, Cohen P, Barzilai N, Atzmon G. Ben-Avraham D, et al. Sci Adv. 2017 Jun 16;3(6):e1602025. doi: 10.1126/sciadv.1602025. eCollection 2017 Jun. Sci Adv. 2017. PMID: 28630896 Free PMC article.
Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.
Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Sebastiani P, et al. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1453-1464. doi: 10.1093/gerona/glx027. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329165 Free PMC article.
Limitations and risks of meta-analyses of longevity studies.
Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT. Sebastiani P, et al. Mech Ageing Dev. 2017 Jul;165(Pt B):139-146. doi: 10.1016/j.mad.2017.01.008. Epub 2017 Jan 28. Mech Ageing Dev. 2017. PMID: 28143747 Free PMC article. Review.
Biomarker signatures of aging.
Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Sebastiani P, et al. Aging Cell. 2017 Apr;16(2):329-338. doi: 10.1111/acel.12557. Epub 2017 Jan 6. Aging Cell. 2017. PMID: 28058805 Free PMC article.
Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population.
Yin X, Wineinger NE, Wang K, Yue W, Norgren N, Wang L, Yao W, Jiang X, Wu B, Cui Y, Shen C, Cheng H, Zhou F, Chen G, Zuo X, Zheng X, Fan X, Wang H, Wang L, Lee J, Lam M, Tai ES, Zhang Z, Huang Q, Sun L, Xu J, Yang S, Wilhelmsen KC, Liu J, Schork NJ, Zhang X. Yin X, et al. J Psychiatry Neurosci. 2016 Oct;41(6):413-421. doi: 10.1503/jpn.150210. J Psychiatry Neurosci. 2016. PMID: 27091718 Free PMC article.
Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations.
Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA. Willcox BJ, et al. J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):724-728. doi: 10.1093/gerona/glw196. J Gerontol A Biol Sci Med Sci. 2017. PMID: 27694344 Free PMC article.
Conservation of Distinct Genetically-Mediated Human Cortical Pattern.
Peng Q, Schork A, Bartsch H, Lo MT, Panizzon MS; Pediatric Imaging, Neurocognition and Genetics Study; Alzheimer’s Disease Neuroimaging Initiative; Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Dale AM, Schork NJ, Chen CH. Peng Q, et al. PLoS Genet. 2016 Jul 26;12(7):e1006143. doi: 10.1371/journal.pgen.1006143. eCollection 2016 Jul. PLoS Genet. 2016. PMID: 27459196 Free PMC article.
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.
Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu YH, Ittermann T, Lahousse L, Liewald DC, Liu Y, Lopez L, Rivadeneira F, Rotter JI, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM. Matteini AM, et al. Aging Cell. 2016 Oct;15(5):792-800. doi: 10.1111/acel.12468. Epub 2016 Jun 21. Aging Cell. 2016. PMID: 27325353 Free PMC article.
Learning Bayesian Networks from Correlated Data.
Bae H, Monti S, Montano M, Steinberg MH, Perls TT, Sebastiani P. Bae H, et al. Sci Rep. 2016 May 5;6:25156. doi: 10.1038/srep25156. Sci Rep. 2016. PMID: 27146517 Free PMC article.
The FoxO3 gene and cause-specific mortality.
Willcox BJ, Tranah GJ, Chen R, Morris BJ, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Davy P, Gerschenson M, Donlon TA. Willcox BJ, et al. Aging Cell. 2016 Aug;15(4):617-24. doi: 10.1111/acel.12452. Epub 2016 Apr 13. Aging Cell. 2016. PMID: 27071935 Free PMC article.
Familial Risk for Exceptional Longevity.
Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Sebastiani P, et al. N Am Actuar J. 2016 Jan 1;20(1):57-64. doi: 10.1080/10920277.2015.1061946. Epub 2015 Oct 7. N Am Actuar J. 2016. PMID: 27041978 Free PMC article.
Novel loci and pathways significantly associated with longevity.
Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW. Zeng Y, et al. Sci Rep. 2016 Feb 25;6:21243. doi: 10.1038/srep21243. Sci Rep. 2016. PMID: 26912274 Free PMC article.
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
Wang B, Merillat SA, Vincent M, Huber AK, Basrur V, Mangelberger D, Zeng L, Elenitoba-Johnson K, Miller RA, Irani DN, Dlugosz AA, Schnell S, Scaglione KM, Paulson HL. Wang B, et al. J Biol Chem. 2016 Feb 5;291(6):3030-42. doi: 10.1074/jbc.M115.676601. Epub 2015 Nov 24. J Biol Chem. 2016. PMID: 26601958 Free PMC article.
Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension.
Morris BJ, Chen R, Donlon TA, Evans DS, Tranah GJ, Parimi N, Ehret GB, Newton-Cheh C, Seto T, Willcox DC, Masaki KH, Kamide K, Ryuno H, Oguro R, Nakama C, Kabayama M, Yamamoto K, Sugimoto K, Ikebe K, Masui Y, Arai Y, Ishizaki T, Gondo Y, Rakugi H, Willcox BJ. Morris BJ, et al. Am J Hypertens. 2016 Nov 1;29(11):1292-1300. doi: 10.1093/ajh/hpv171. Am J Hypertens. 2016. PMID: 26476085 Free PMC article.
Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society.
Nikolich-Žugich J, Goldman DP, Cohen PR, Cortese D, Fontana L, Kennedy BK, Mohler MJ, Olshansky SJ, Perls T, Perry D, Richardson A, Ritchie C, Wertheimer AM, Faragher RG, Fain MJ. Nikolich-Žugich J, et al. J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):435-44. doi: 10.1093/gerona/glv164. Epub 2015 Sep 29. J Gerontol A Biol Sci Med Sci. 2016. PMID: 26419976 Free PMC article.
Measures of Healthspan as Indices of Aging in Mice-A Recommendation.
Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN. Richardson A, et al. J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):427-30. doi: 10.1093/gerona/glv080. Epub 2015 Aug 22. J Gerontol A Biol Sci Med Sci. 2016. PMID: 26297941 Free PMC article.
Large-scale genomics unveil polygenic architecture of human cortical surface area.
Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ; Pediatric Imaging, Neurocognition and Genetics Study; Alzheimer’s Disease Neuroimaging Initiative; Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Schork N, Dale AM; Pediatric Imaging Neurocognition and Genetics Study; Alzheimer's Disease Neuroimaging Initiative. Chen CH, et al. Nat Commun. 2015 Jul 20;6:7549. doi: 10.1038/ncomms8549. Nat Commun. 2015. PMID: 26189703 Free PMC article.
Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.
Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciąg A, Damato A, Auricchio A, Spinetti G, Sangalli E, Dang Z, Madonna M, Ambrosio M, Sitia L, Bigini P, Calì G, Schreiber S, Perls T, Fucile S, Mulas F, Nebel A, Bellazzi R, Madeddu P, Vecchione C, Puca AA. Villa F, et al. Circ Res. 2015 Jul 31;117(4):333-45. doi: 10.1161/CIRCRESAHA.117.305875. Epub 2015 Jun 1. Circ Res. 2015. PMID: 26034043 Free PMC article.
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