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The amino analogue of β-boswellic acid efficiently attenuates the release of pro-inflammatory mediators than its parent compound through the suppression of NF-κB/IκBα signalling axis.
Gupta S, Ahsan AU, Wani A, Khajuria V, Nazir LA, Sharma S, Bhagat A, Raj Sharma P, Bhardwaj S, Peerzada KJ, Ali Shah B, Ahmed Z. Gupta S, et al. Among authors: ahsan au. Cytokine. 2018 Jul;107:93-104. doi: 10.1016/j.cyto.2017.12.004. Epub 2017 Dec 8. Cytokine. 2018. PMID: 29229421
Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization.
Gupta M, Wani A, Ahsan AU, Ali M, Chibber P, Singh S, Digra SK, Datt M, Bharate SB, Vishwakarma RA, Singh G, Kumar A. Gupta M, et al. Among authors: ahsan au. Toxicol Appl Pharmacol. 2021 Jul 15;423:115582. doi: 10.1016/j.taap.2021.115582. Epub 2021 May 18. Toxicol Appl Pharmacol. 2021. PMID: 34019860