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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 2
2002 2
2003 4
2005 9
2006 2
2007 3
2008 5
2009 3
2010 5
2011 6
2012 7
2013 8
2014 11
2015 17
2016 12
2017 10
2018 17
2019 16
2020 9
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2022 17
2023 17
2024 1

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179 results

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Page 1
Ajuba: An emerging signal transducer in oncogenesis.
Jia H, Peng H, Hou Z. Jia H, et al. Pharmacol Res. 2020 Jan;151:104546. doi: 10.1016/j.phrs.2019.104546. Epub 2019 Nov 15. Pharmacol Res. 2020. PMID: 31740385 Review.
Additionally, Ajuba contains both nuclear export sequences (NES) and nuclear localization sequences (NLS), which enable Ajuba shuttle between the cytoplasm and the nucleus. ...In this review, we aim to summarize the up-to-date literatures on the signaling pathways m …
Additionally, Ajuba contains both nuclear export sequences (NES) and nuclear localization sequences (NLS), which enable Ajuba …
AJUBA: A regulator of epidermal homeostasis and cancer.
Schleicher K, Schramek D. Schleicher K, et al. Exp Dermatol. 2021 Apr;30(4):546-559. doi: 10.1111/exd.14272. Epub 2021 Jan 26. Exp Dermatol. 2021. PMID: 33372298 Review.
AJUBA regulates proliferation of skin stem cells through Hippo and Wnt signalling and encourages mitotic commitment through Aurora-A, Aurora-B and CDK1. ...AJUBA also plays an imperative context-dependent tumor-promoting and tumor-suppressive role within epithelial …
AJUBA regulates proliferation of skin stem cells through Hippo and Wnt signalling and encourages mitotic commitment through Aurora-A, …
Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ-GLUT3/Survivin Pathway.
Li X, Zhao G, Mi X, Xu T, Li X, Liu B. Li X, et al. Biomed Res Int. 2022 Feb 7;2022:3321409. doi: 10.1155/2022/3321409. eCollection 2022. Biomed Res Int. 2022. PMID: 35178446 Free PMC article.
The Ajuba expression level was elevated in breast cancer tissue compared with normal tissue. ...The Ajuba protein level was also higher in BC cell lines compared to normal breast epithelial cell line MCF-10A. ...
The Ajuba expression level was elevated in breast cancer tissue compared with normal tissue. ...The Ajuba protein level was al …
Ajuba transactivates N-cadherin expression in colorectal cancer cells through interaction with Twist.
Wu Z, Zou X, Xu Y, Zhou F, Kuai R, Li J, Yang D, Chu Y, Peng H. Wu Z, et al. J Cell Mol Med. 2021 Aug;25(16):8006-8014. doi: 10.1111/jcmm.16731. Epub 2021 Jun 26. J Cell Mol Med. 2021. PMID: 34173718 Free PMC article.
Biologically, Ajuba enhances transcription of target gene N-cadherin as an obligate coactivator of Twist. ...These findings identify that Twist is a new interacting protein of Ajuba and Ajuba/Twist/CBP ternary complex may be a potential treatment strategy for …
Biologically, Ajuba enhances transcription of target gene N-cadherin as an obligate coactivator of Twist. ...These findings identify …
AJUBA and WTIP can compete with LIMD1 for junctional localization and LATS regulation.
Kirichenko E, Irvine KD. Kirichenko E, et al. MicroPubl Biol. 2022 Nov 9;2022:10.17912/micropub.biology.000666. doi: 10.17912/micropub.biology.000666. eCollection 2022. MicroPubl Biol. 2022. PMID: 36439396 Free PMC article.
Each of the three mammalian Ajuba family proteins, AJUBA, LIMD1 and WTIP, exhibit tension-dependent localization to adherens junctions, and can associate with Lats kinases. However, only LIMD1 has been directly demonstrated to directly regulate Lats activity in vivo …
Each of the three mammalian Ajuba family proteins, AJUBA, LIMD1 and WTIP, exhibit tension-dependent localization to adherens j …
Ajuba proteins.
Schimizzi GV, Longmore GD. Schimizzi GV, et al. Curr Biol. 2015 Jun 1;25(11):R445-6. doi: 10.1016/j.cub.2015.02.034. Curr Biol. 2015. PMID: 26035782 Free article.
Schimizzi and Longmore summarise what we know about Ajuba LIM-domain proteins and their various subcellular roles....
Schimizzi and Longmore summarise what we know about Ajuba LIM-domain proteins and their various subcellular roles....
Ajuba overexpression regulates mitochondrial potential and glucose uptake through YAP/Bcl-xL/GLUT1 in human gastric cancer.
Li H, Fu L, Liu B, Lin X, Dong Q, Wang E. Li H, et al. Gene. 2019 Apr 20;693:16-24. doi: 10.1016/j.gene.2019.01.018. Epub 2019 Jan 25. Gene. 2019. PMID: 30690182
MTT and colony formation assays indicated that Ajuba overexpression increased proliferation rate and colony formation ability while Ajuba siRNA inhibited proliferation rate and colony formation ability. ...Ajuba overexpression also inhibited caspase-3 and PAR …
MTT and colony formation assays indicated that Ajuba overexpression increased proliferation rate and colony formation ability while …
miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma.
Zhang J, Guo Y, Ma Y, Wang L, Li W, Zhang M, Zhao J, Hu Y, Yu H, Hu G. Zhang J, et al. Neuroimmunomodulation. 2022;29(1):44-54. doi: 10.1159/000518084. Epub 2021 Sep 10. Neuroimmunomodulation. 2022. PMID: 34518486
RESULTS: In addition, after overexpressing miR-433-3p and AJUBA, it was found that overexpressing AJUBA could attenuate the inhibitory effect of overexpressing miR-433-3p on the proliferation, migration, and invasion of glioma cells, which suggested that miR-433-3p …
RESULTS: In addition, after overexpressing miR-433-3p and AJUBA, it was found that overexpressing AJUBA could attenuate the in …
Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins.
Gilhaus K, Cepok C, Kamm D, Surmann B, Nedvetsky PI, Emich J, Sundukova A, Saatkamp K, Nüsse H, Klingauf J, Wennmann DO, George B, Krahn MP, Pavenstädt HJ, Vollenbröker BA. Gilhaus K, et al. J Am Soc Nephrol. 2023 Jun 1;34(6):1039-1055. doi: 10.1681/ASN.0000000000000107. Epub 2023 Mar 16. J Am Soc Nephrol. 2023. PMID: 36930055
RESULTS: In nephrocytes, the Ajuba homolog Djub recruited Warts (LATS2 homolog) to the SD. Knockdown of Djub activated the Hippo pathway. ...In podocytes, Hippo pathway activation or knockdown of YAP also decreased the level of Ajuba proteins. CONCLUSIONS: Ajuba …
RESULTS: In nephrocytes, the Ajuba homolog Djub recruited Warts (LATS2 homolog) to the SD. Knockdown of Djub activated the Hippo path …
AJUBA increases the cisplatin resistance through hippo pathway in cervical cancer.
Bi L, Ma F, Tian R, Zhou Y, Lan W, Song Q, Cheng X. Bi L, et al. Gene. 2018 Feb 20;644:148-154. doi: 10.1016/j.gene.2017.11.017. Epub 2017 Nov 7. Gene. 2018. PMID: 29126926
Though LIM-domain protein AJUBA was identified as a putative oncogene, the function and underlying mechanisms of AJUBA in cervical cancer remain largely unknown. ...In addition, overall survival time was significantly shorter in the cervical cancer patients with hig …
Though LIM-domain protein AJUBA was identified as a putative oncogene, the function and underlying mechanisms of AJUBA in cerv …
179 results