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1998 4
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Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene.
Gusho E, Zhang R, Jha BK, Thornbrough JM, Dong B, Gaughan C, Elliott R, Weiss SR, Silverman RH. Gusho E, et al. mBio. 2014 Jul 1;5(4):e01312-14. doi: 10.1128/mBio.01312-14. mBio. 2014. PMID: 24987090 Free PMC article.
The AKAP7 PDE domain or N-terminally truncated AKAP7 (both lacking a nuclear localization motif), but not full-length AKAP7 or a mutant, AKAP7(H185R), PDE domain restored the infectivity of ns2 mutant MHV in bone marrow macrophages and in livers of inf …
The AKAP7 PDE domain or N-terminally truncated AKAP7 (both lacking a nuclear localization motif), but not full-length AKAP7 …
Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
Jones BW, Deem J, Younts TJ, Weisenhaus M, Sanford CA, Slack MC, Chin J, Nachmanson D, McKennon A, Castillo PE, McKnight GS. Jones BW, et al. Elife. 2016 Dec 2;5:e20695. doi: 10.7554/eLife.20695. Elife. 2016. PMID: 27911261 Free PMC article.
Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LTP directly initiated by cAMP, and the AKAP7 mutan …
Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals. Genetic ablation of …
Overexpression of miR-669m inhibits erythroblast differentiation.
Kotaki R, Kawashima M, Yamaguchi A, Suzuki N, Koyama-Nasu R, Ogiya D, Okuyama K, Yamamoto Y, Takamatsu M, Kurosaki N, Ando K, Murata A, Ohtsuka M, Nakagawa S, Katagiri K, Kotani A. Kotaki R, et al. Sci Rep. 2020 Aug 11;10(1):13554. doi: 10.1038/s41598-020-70442-y. Sci Rep. 2020. PMID: 32782283 Free PMC article.
Further, miR-669m suppressed luciferase reporters for 3' untranslated regions of Akap7 and Xk genes, which supports these genes are direct targets of miR-669m. Physiologically, miR-669m was not expressed in the erythroblast. In conclusion, using miR-669m, we found Akap7 …
Further, miR-669m suppressed luciferase reporters for 3' untranslated regions of Akap7 and Xk genes, which supports these genes are d …
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
Jones BW, Brunet S, Gilbert ML, Nichols CB, Su T, Westenbroek RE, Scott JD, Catterall WA, McKnight GS. Jones BW, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17099-104. doi: 10.1073/pnas.1215219109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035250 Free PMC article.
Phosphorylation of Ca(V)1.2 and PLN were also unaffected by genetic deletion of AKAP7. Immunoblot and RT-PCR revealed that only the long isoforms of AKAP7 were detectable in ventricular cardiomyocytes. The results indicate that AKAP7 is not required for regul …
Phosphorylation of Ca(V)1.2 and PLN were also unaffected by genetic deletion of AKAP7. Immunoblot and RT-PCR revealed that only the l …
Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption.
O'Connell GC, Treadway MB, Petrone AB, Tennant CS, Lucke-Wold N, Chantler PD, Barr TL. O'Connell GC, et al. Sci Rep. 2017 Apr 26;7(1):1172. doi: 10.1038/s41598-017-01178-5. Sci Rep. 2017. PMID: 28446746 Free PMC article.
We then determined that AKAP7 is predominantly expressed by lymphocytes in peripheral blood, and strongly co-expressed with ITGA3, a gene encoding the adhesion molecule integrin alpha 3. Subsequent in vitro experiments revealed that heightened expression of AKAP7 an …
We then determined that AKAP7 is predominantly expressed by lymphocytes in peripheral blood, and strongly co-expressed with ITGA3, a …
Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms.
Redden JM, Le AV, Singh A, Federkiewicz K, Smith S, Dodge-Kafka KL. Redden JM, et al. Biochem J. 2012 Sep 1;446(2):301-9. doi: 10.1042/BJ20120366. Biochem J. 2012. PMID: 22670899
FRET (fluorescence resonance energy transfer) analysis using a PKC activity reporter suggests that anchoring of the kinase within AKAP7 complexes enhances the phosphorylation of substrate proteins. ...Collectively, the results of the present study suggests that AKAP7 …
FRET (fluorescence resonance energy transfer) analysis using a PKC activity reporter suggests that anchoring of the kinase within AKAP7 …
A Novel Approach to Link Genetics and Human MRI Identifies AKAP7-Dependent Subicular/Prefrontal Functional Connectivity as Altered in Suicidality.
Poblete G, Nguyen T, Gosnell S, Sofela O, Patriquin M, Mathew SJ, Swann A, Nielsen DA, Kosten TR, Salas R. Poblete G, et al. Chronic Stress (Thousand Oaks). 2022 Mar 21;6:24705470221083700. doi: 10.1177/24705470221083700. eCollection 2022 Jan-Dec. Chronic Stress (Thousand Oaks). 2022. PMID: 35340866 Free PMC article.
We genotyped one single nucleotide polymorphism (SNP) in each of the five genes (within 130 from GWAS) with most important subicular expression. AKAP7 (A-Kinase Anchoring Protein 7, important in hippocampal memory processes) showed an interaction between genotype, ATT, and …
We genotyped one single nucleotide polymorphism (SNP) in each of the five genes (within 130 from GWAS) with most important subicular express …
Molecular evolution of A-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization.
Johnson KR, Nicodemus-Johnson J, Carnegie GK, Danziger RS. Johnson KR, et al. BMC Evol Biol. 2012 Jul 26;12:125. doi: 10.1186/1471-2148-12-125. BMC Evol Biol. 2012. PMID: 22834419 Free PMC article.
Species analyses of AKAP7 splice variants shows the ancestral AKAP7 splice variant is AKAP7alpha, while the ancestral long form AKAP7 splice variant is AKAP7gamma. Multi-species AKAP7 gene alignments, show the recent formation of AKAP7delta occurs with …
Species analyses of AKAP7 splice variants shows the ancestral AKAP7 splice variant is AKAP7alpha, while the ancestral long for …
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM. Carlson CR, et al. Circ Res. 2022 Jan 7;130(1):27-44. doi: 10.1161/CIRCRESAHA.120.317976. Epub 2021 Nov 24. Circ Res. 2022. PMID: 34814703 Free PMC article.
67 results