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Year Number of Results
1994 1
1998 1
1999 1
2000 6
2001 4
2002 4
2003 5
2008 1
2013 2
2014 1
2015 1
2016 1
2018 5
2019 1
2020 2
2022 5
2023 2
2024 0

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42 results

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Page 1
AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA.
Zhang R, Liu L, Wang F, Zhao W, Liu K, Yu H, Zhao S, Xu B, Zhang X, Chai J, Hao J. Zhang R, et al. Cell Death Dis. 2022 Dec 15;13(12):1041. doi: 10.1038/s41419-022-05502-4. Cell Death Dis. 2022. PMID: 36522343 Free PMC article.
Taken together, our results demonstrated that AKAP-8L facilitates GC chemoresistance via regulating SCD1-mediated stemness of GC cells. AKAP8L may represent a novel therapeutic target to overcome GC chemoresistance....
Taken together, our results demonstrated that AKAP-8L facilitates GC chemoresistance via regulating SCD1-mediated stemness of GC cells. A …
Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer.
Zhou L, Mei J, Cao R, Liu X, Fu B, Ma M, Gong B, Luo L, Liu Y, Zhu Q, Meng X. Zhou L, et al. Aging (Albany NY). 2023 Sep 7;15(17):8851-8872. doi: 10.18632/aging.205003. Epub 2023 Sep 7. Aging (Albany NY). 2023. PMID: 37683130 Free PMC article.
A-kinase anchoring protein 8L (AKAP8L) belong to the A-kinase anchoring protein (AKAP) family. Recent studies have proved that AKAP8L is associated with the progression of various tumors. ...We also performed the immunohistochemical staining and semi-quantitative ve …
A-kinase anchoring protein 8L (AKAP8L) belong to the A-kinase anchoring protein (AKAP) family. Recent studies have proved that AKA …
High AKAP8L expression predicts poor prognosis in esophageal squamous cell carcinoma.
Luo QY, Di T, Qiu MZ, Xia ZF, Du Y, Lin RD, Yang LQ, Sun YT, Yang DJ, Sun J, Zhang L. Luo QY, et al. Cancer Cell Int. 2022 Feb 21;22(1):90. doi: 10.1186/s12935-022-02492-3. Cancer Cell Int. 2022. PMID: 35189899 Free PMC article.
However, the role of AKAP8L in ESCC remains unclear. The aim of this study is to investigate the expression patterns and prognostic value of AKAP8L in ESCC. ...The comparison of the different clinicopathological features of ESCC between high and low AKAP8L ex …
However, the role of AKAP8L in ESCC remains unclear. The aim of this study is to investigate the expression patterns and prognostic v …
A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth.
Melick CH, Meng D, Jewell JL. Melick CH, et al. J Biol Chem. 2020 Jun 5;295(23):8096-8105. doi: 10.1074/jbc.AC120.012595. Epub 2020 Apr 20. J Biol Chem. 2020. PMID: 32312749 Free PMC article.
Here, we identified a novel mTORC1-interacting protein called protein kinase A anchoring protein 8L (AKAP8L). Using biochemical assays, we found that the N-terminal region of AKAP8L binds to mTORC1 in the cytoplasm. ...We conclude that mTORC1 appears to regulate cel …
Here, we identified a novel mTORC1-interacting protein called protein kinase A anchoring protein 8L (AKAP8L). Using biochemical assay …
Novel prognostic model predicts overall survival in colon cancer based on RNA splicing regulation gene expression.
Luo QY, Di T, Chen ZG, Peng JH, Sun J, Xia ZF, Pan WT, Luo F, Lu FT, Sun YT, Yang LQ, Zhang L, Qiu MZ, Yang DJ. Luo QY, et al. Cancer Sci. 2022 Oct;113(10):3330-3346. doi: 10.1111/cas.15480. Epub 2022 Aug 16. Cancer Sci. 2022. PMID: 35792657 Free PMC article.
Animal studies have also shown that AKAP8L knockdown can inhibit tumor growth in colon cancer in vivo. We established a prognostic risk model for colon cancer based on genes related to RNA splicing regulation and uncovered the role of AKAP8L in promoting colon cance …
Animal studies have also shown that AKAP8L knockdown can inhibit tumor growth in colon cancer in vivo. We established a prognostic ri …
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Pintacuda G, Hsu YH, Tsafou K, Li KW, Martín JM, Riseman J, Biagini JC, Ching JKT, Mena D, Gonzalez-Lozano MA, Egri SB, Jaffe J, Smit AB, Fornelos N, Eggan KC, Lage K. Pintacuda G, et al. Cell Genom. 2023 Jan 24;3(3):100250. doi: 10.1016/j.xgen.2022.100250. eCollection 2023 Mar 8. Cell Genom. 2023. PMID: 36950384 Free PMC article.
We leveraged the network data to show that the ASD-linked brain-specific isoform of ANK2 is important for its interactions with synaptic proteins and to characterize a PTEN-AKAP8L interaction that influences neuronal growth. The IGF2BP1-3 complex emerged as a convergent po …
We leveraged the network data to show that the ASD-linked brain-specific isoform of ANK2 is important for its interactions with synaptic pro …
Reciprocal Relationship between Head Size, an Autism Endophenotype, and Gene Dosage at 19p13.12 Points to AKAP8 and AKAP8L.
Nebel RA, Kirschen J, Cai J, Woo YJ, Cherian K, Abrahams BS. Nebel RA, et al. PLoS One. 2015 Jun 15;10(6):e0129270. doi: 10.1371/journal.pone.0129270. eCollection 2015. PLoS One. 2015. PMID: 26076356 Free PMC article.
Data support A kinase anchor protein 8 and 8-like (AKAP8 and AKAP8L) as candidate genes involved in regulation of head growth, an interesting finding given previous work implicating the AKAP gene family in autism. ...Taken together, findings support the idea that gene dosa …
Data support A kinase anchor protein 8 and 8-like (AKAP8 and AKAP8L) as candidate genes involved in regulation of head growth, an int …
Identification of key biomarkers and signaling pathways and analysis of their association with immune cells in immunoglobulin A nephropathy.
Zhang G, Xue L, Zhang S, Liu N, Yao X, Fu J, Nie L. Zhang G, et al. Cent Eur J Immunol. 2022;47(3):189-205. doi: 10.5114/ceji.2022.119867. Epub 2022 Sep 29. Cent Eur J Immunol. 2022. PMID: 36817268 Free PMC article.
In addition, the distribution of 8 immune cell types was found to be significantly different between normal controls and IgAN by difference analysis. Pearson correlation coefficient analysis demonstrated that AKAP8L was significantly negatively correlated with CD4(+) memor …
In addition, the distribution of 8 immune cell types was found to be significantly different between normal controls and IgAN by difference …
Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.
Huang P, Zhao Y, Zhong J, Zhang X, Liu Q, Qiu X, Chen S, Yan H, Hillyer C, Mohandas N, Pan X, Xu X. Huang P, et al. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12868-12876. doi: 10.1073/pnas.1915085117. Epub 2020 May 26. Proc Natl Acad Sci U S A. 2020. PMID: 32457162 Free PMC article.
We further identified a set of putative regulators of terminal erythroid differentiation and functionally validated three of the identified genes, AKAP8L, TERF2IP, and RNF10, by monitoring cell differentiation and apoptosis. We documented that knockdown of AKAP8L su …
We further identified a set of putative regulators of terminal erythroid differentiation and functionally validated three of the identified …
PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein.
Bieluszewska A, Weglewska M, Bieluszewski T, Lesniewicz K, Poreba E. Bieluszewska A, et al. FEBS J. 2018 Mar;285(5):947-964. doi: 10.1111/febs.14378. Epub 2018 Jan 22. FEBS J. 2018. PMID: 29288530 Free article.
We further demonstrate that AKAP8 interacts with DPY30 and the RII alpha regulatory subunit of PKA both in the interphase and in mitotic cells, and we show evidences that AKAP8L, a homologue of AKAP8, interacts with core subunits of the H3K4 HMT complexes, which suggests i …
We further demonstrate that AKAP8 interacts with DPY30 and the RII alpha regulatory subunit of PKA both in the interphase and in mitotic cel …
42 results