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Page 1
SHP2 inhibition displays efficacy as a monotherapy and in combination with JAK2 inhibition in preclinical models of myeloproliferative neoplasms.
Pandey G, Mazzacurati L, Rowsell TM, Horvat NP, Amin NE, Zhang G, Akuffo AA, Colin-Leitzinger CM, Haura EB, Kuykendall AT, Zhang L, Epling-Burnette PK, Reuther GW. Pandey G, et al. Among authors: akuffo aa. Am J Hematol. 2024 Mar 5. doi: 10.1002/ajh.27282. Online ahead of print. Am J Hematol. 2024. PMID: 38440831
Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes.
Hesterberg RS, Beatty MS, Han Y, Fernandez MR, Akuffo AA, Goodheart WE, Yang C, Chang S, Colin CM, Alontaga AY, McDaniel JM, Mailloux AW, Billington JMR, Yue L, Russell S, Gillies RJ, Yun SY, Ayaz M, Lawrence NJ, Lawrence HR, Yu XZ, Fu J, Darville LN, Koomen JM, Ren X, Messina J, Jiang K, Garrett TJ, Rajadhyaksha AM, Cleveland JL, Epling-Burnette PK. Hesterberg RS, et al. Among authors: akuffo aa. Blood. 2020 Aug 13;136(7):857-870. doi: 10.1182/blood.2019003257. Blood. 2020. PMID: 32403132 Free PMC article.
HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms.
Yue L, Sharma V, Horvat NP, Akuffo AA, Beatty MS, Murdun C, Colin C, Billington JMR, Goodheart WE, Sahakian E, Zhang L, Powers JJ, Amin NE, Lambert-Showers QT, Darville LN, Pinilla-Ibarz J, Reuther GW, Wright KL, Conti C, Lee JY, Zheng X, Ng PY, Martin MW, Marshall CG, Koomen JM, Levine RL, Verma A, Grimes HL, Sotomayor EM, Shao Z, Epling-Burnette PK. Yue L, et al. Among authors: akuffo aa. Blood. 2020 Jan 16;135(3):191-207. doi: 10.1182/blood.2019895326. Blood. 2020. PMID: 31750881 Free PMC article.
Cross-sectional associations between cutaneous viral infections and regulatory T lymphocytes in circulation.
Hampras SS, Tommasino M, Zhao Y, Messina JL, Giuliano AR, Fenske NA, Cherpelis B, Hesterberg RS, Akuffo AA, Amorrortu RP, Balliu J, Vijayan L, Gheit T, Epling-Burnette PK, Rollison DE. Hampras SS, et al. Among authors: akuffo aa. Br J Dermatol. 2019 Jun;180(6):1449-1458. doi: 10.1111/bjd.17429. Epub 2019 Feb 10. Br J Dermatol. 2019. PMID: 30431148 Free PMC article.
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, Yoder JA, Rajadhyaksha AM, Schönbrunn E, Lawrence HR, Lawrence NJ, Epling-Burnette PK. Akuffo AA, et al. J Biol Chem. 2018 Apr 20;293(16):6187-6200. doi: 10.1074/jbc.M117.816868. Epub 2018 Feb 15. J Biol Chem. 2018. PMID: 29449372 Free PMC article.