Alagramam KN - Search Results

1

Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation.

Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Geng R, et al. Among authors: alagramam kn. Hum Mol Genet. 2009 Aug 1;18(15):2748-60. doi: 10.1093/hmg/ddp210. Epub 2009 May 3. Hum Mol Genet. 2009. PMID: 19414487 Free PMC article.

2

Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F.

Alagramam KN, Stahl JS, Jones SM, Pawlowski KS, Wright CG. Alagramam KN, et al. J Assoc Res Otolaryngol. 2005 Jun;6(2):106-18. doi: 10.1007/s10162-004-5032-3. Epub 2005 Jun 10. J Assoc Res Otolaryngol. 2005. PMID: 15952048 Free PMC article.

3

Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton.

Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Tian G, et al. Among authors: alagramam kn. J Biol Chem. 2009 Jul 10;284(28):18980-93. doi: 10.1074/jbc.M109.003160. Epub 2009 May 7. J Biol Chem. 2009. PMID: 19423712 Free PMC article.

4

The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.

Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN. Geng R, et al. Among authors: alagramam kn. J Neurosci. 2012 Jul 11;32(28):9485-98. doi: 10.1523/JNEUROSCI.0311-12.2012. J Neurosci. 2012. PMID: 22787034 Free PMC article.

5

Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F.

Chance MR, Chang J, Liu S, Gokulrangan G, Chen DH, Lindsay A, Geng R, Zheng QY, Alagramam K. Chance MR, et al. Hum Mol Genet. 2010 Apr 15;19(8):1515-27. doi: 10.1093/hmg/ddq025. Epub 2010 Jan 22. Hum Mol Genet. 2010. PMID: 20097680 Free PMC article.

6

Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development.

Pawlowski KS, Kikkawa YS, Wright CG, Alagramam KN. Pawlowski KS, et al. Among authors: alagramam kn. J Assoc Res Otolaryngol. 2006 Jun;7(2):83-94. doi: 10.1007/s10162-005-0024-5. Epub 2006 Jan 12. J Assoc Res Otolaryngol. 2006. PMID: 16408167 Free PMC article.

7

Development of outer hair cells in Ames waltzer mice: mutation in protocadherin 15 affects development of cuticular plate and associated structures.

Kikkawa YS, Pawlowski KS, Wright CG, Alagramam KN. Kikkawa YS, et al. Among authors: alagramam kn. Anat Rec (Hoboken). 2008 Feb;291(2):224-32. doi: 10.1002/ar.20632. Anat Rec (Hoboken). 2008. PMID: 18085631 Free article.

8

Spiral ganglion loss outpaces inner hair cell loss in endolymphatic hydrops.

Momin SR, Melki SJ, Alagramam KN, Megerian CA. Momin SR, et al. Among authors: alagramam kn. Laryngoscope. 2010 Jan;120(1):159-65. doi: 10.1002/lary.20673. Laryngoscope. 2010. PMID: 19877178

9

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.

Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. Alagramam KN, et al. Nat Chem Biol. 2016 Jun;12(6):444-51. doi: 10.1038/nchembio.2069. Epub 2016 Apr 25. Nat Chem Biol. 2016. PMID: 27110679 Free PMC article.

10

Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III.

Geng R, Omar A, Gopal SR, Chen DH, Stepanyan R, Basch ML, Dinculescu A, Furness DN, Saperstein D, Hauswirth W, Lustig LR, Alagramam KN. Geng R, et al. Among authors: alagramam kn. Sci Rep. 2017 Oct 18;7(1):13480. doi: 10.1038/s41598-017-13620-9. Sci Rep. 2017. PMID: 29044151 Free PMC article.

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