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Page 1
Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.
Andrés JI, Alcázar J, Cid JM, De Angelis M, Iturrino L, Langlois X, Lavreysen H, Trabanco AA, Celen S, Bormans G. Andrés JI, et al. Among authors: alcazar j. J Med Chem. 2012 Oct 25;55(20):8685-99. doi: 10.1021/jm300912k. Epub 2012 Oct 11. J Med Chem. 2012. PMID: 22992024
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.
Andrés JI, Alcázar J, Alonso JM, Díaz A, Fernández J, Gil P, Iturrino L, Matesanz E, Meert TF, Megens A, Sipido VK. Andrés JI, et al. Among authors: alcazar j. Bioorg Med Chem Lett. 2002 Jan 21;12(2):243-8. doi: 10.1016/s0960-894x(01)00721-1. Bioorg Med Chem Lett. 2002. PMID: 11755364
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.
Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Cid JM, De Lucas AI, Fernández J, Martínez S, Nieto C, Pastor J, Bakker MH, Biesmans I, Heylen LI, Megens AA. Andrés JI, et al. Among authors: alcazar j. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2719-25. doi: 10.1016/s0960-894x(03)00525-0. Bioorg Med Chem Lett. 2003. PMID: 12873501
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.
Pastor J, Alcázar J, Alvarez RM, Andrés JI, Cid JM, De Lucas AI, Díaz A, Fernández J, Font LM, Iturrino L, Lafuente C, Martínez S, Bakker MH, Biesmans I, Heylen LI, Megens AA. Pastor J, et al. Among authors: alcazar j. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2917-22. doi: 10.1016/j.bmcl.2004.03.031. Bioorg Med Chem Lett. 2004. PMID: 15125959
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.
Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Fernández J, Font LM, Hens KA, Iturrino L, Lenaerts I, Martínez S, Megens AA, Pastor J, Vermote PC, Steckler T. Andrés JI, et al. Among authors: alcazar j. J Med Chem. 2005 Mar 24;48(6):2054-71. doi: 10.1021/jm049619s. J Med Chem. 2005. PMID: 15771448
Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.
Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Drinkenburg W, Fernández J, Font LM, Iturrino L, Langlois X, Lenaerts I, Martínez S, Megens AA, Pastor J, Pullan S, Steckler T. Andrés JI, et al. Among authors: alcazar j. Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. doi: 10.1016/j.bmc.2007.03.053. Epub 2007 Mar 21. Bioorg Med Chem. 2007. PMID: 17407815
Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain.
Celen S, Koole M, De Angelis M, Sannen I, Chitneni SK, Alcazar J, Dedeurwaerdere S, Moechars D, Schmidt M, Verbruggen A, Langlois X, Van Laere K, Andrés JI, Bormans G. Celen S, et al. Among authors: alcazar j. J Nucl Med. 2010 Oct;51(10):1584-91. doi: 10.2967/jnumed.110.077040. Epub 2010 Sep 16. J Nucl Med. 2010. PMID: 20847170 Free article.
537 results