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Did you mean aldo (22,097 results)?
ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation.
Bai D, Du J, Bu X, Cao W, Sun T, Zhao J, Zhao Y, Lu N. Bai D, et al. Autophagy. 2022 Jul;18(7):1673-1693. doi: 10.1080/15548627.2021.1997051. Epub 2021 Nov 25. Autophagy. 2022. PMID: 34821530 Free PMC article.
ALDOA: aldolase A; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG5: autophagy related 5; ATP: adenosine triphosphate; BMDMs: bone marrow-derived macrophages; CALCOCO2: calcium binding and coiled-coil domain 2; CASP1: caspase 1; CQ: chloroquine; FOXO3: fork …
ALDOA: aldolase A; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG5: autophagy related 5; ATP: adenosine triphosphate …
The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity.
Lin J, Xia L, Oyang L, Liang J, Tan S, Wu N, Yi P, Pan Q, Rao S, Han Y, Tang Y, Su M, Luo X, Yang Y, Chen X, Yang L, Zhou Y, Liao Q. Lin J, et al. Oncogene. 2022 Feb;41(7):1024-1039. doi: 10.1038/s41388-021-02148-y. Epub 2022 Jan 8. Oncogene. 2022. PMID: 34997215 Free PMC article.
POU2F1 enhanced the proliferation, aerobic glycolysis and the pentose phosphate pathway (PPP) activity, but reduced oxidative stress and apoptosis in colon cancer cells, dependent on up-regulating ALDOA expression. Mechanistically, POU2F1 directly bound to the ALDOA …
POU2F1 enhanced the proliferation, aerobic glycolysis and the pentose phosphate pathway (PPP) activity, but reduced oxidative stress and apo …
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma.
Gao Q, Zhu H, Dong L, Shi W, Chen R, Song Z, Huang C, Li J, Dong X, Zhou Y, Liu Q, Ma L, Wang X, Zhou J, Liu Y, Boja E, Robles AI, Ma W, Wang P, Li Y, Ding L, Wen B, Zhang B, Rodriguez H, Gao D, Zhou H, Fan J. Gao Q, et al. Cell. 2019 Oct 3;179(2):561-577.e22. doi: 10.1016/j.cell.2019.08.052. Cell. 2019. PMID: 31585088 Free article.
CTNNB1 and TP53 mutation-associated signaling and metabolic profiles were revealed, among which mutated CTNNB1-associated ALDOA phosphorylation was validated to promote glycolysis and cell proliferation. ...
CTNNB1 and TP53 mutation-associated signaling and metabolic profiles were revealed, among which mutated CTNNB1-associated ALDOA phosp …
Blockade of PGK1 and ALDOA enhances bilirubin control of Th17 cells in Crohn's disease.
Vuerich M, Wang N, Graham JJ, Gao L, Zhang W, Kalbasi A, Zhang L, Csizmadia E, Hristopoulos J, Ma Y, Kokkotou E, Cheifetz AS, Robson SC, Longhi MS. Vuerich M, et al. Commun Biol. 2022 Sep 21;5(1):994. doi: 10.1038/s42003-022-03913-9. Commun Biol. 2022. PMID: 36131123 Free PMC article.
Here we show that UCB modulates Th17-cell metabolism by limiting glycolysis and through downregulation of glycolysis-related genes, namely phosphoglycerate-kinase-1 (PGK1) and aldolase-A (ALDOA). Th17-cells of Crohn's disease patients display heightened PGK1 and ALDOA …
Here we show that UCB modulates Th17-cell metabolism by limiting glycolysis and through downregulation of glycolysis-related genes, namely p …
The ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation.
Kuang Q, Liang Y, Zhuo Y, Cai Z, Jiang F, Xie J, Zheng Y, Zhong W. Kuang Q, et al. Onco Targets Ther. 2021 May 24;14:3353-3366. doi: 10.2147/OTT.S290284. eCollection 2021. Onco Targets Ther. 2021. PMID: 34079281 Free PMC article.
The potential roles of ALDOA in malignant progression were verified using a series of in vivo and in vitro experiments after stable ALDOA overexpression and knockdown in DU145 and PC3 cell lines. ...The analysis of datasets from the Taylor database showed that there …
The potential roles of ALDOA in malignant progression were verified using a series of in vivo and in vitro experiments after stable …
The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair.
Sobanski T, Suraweera A, Burgess JT, Richard I, Cheong CM, Dave K, Rose M, Adams MN, O'Byrne KJ, Richard DJ, Bolderson E. Sobanski T, et al. Sci Rep. 2023 Sep 13;13(1):15171. doi: 10.1038/s41598-023-41133-1. Sci Rep. 2023. PMID: 37704669 Free PMC article.
DNA damage was shown to be elevated in ALDOA-depleted cells prior to IR and following IR the damage was repaired more slowly. ...Together, these data establish a role for an essential metabolic protein, ALDOA in DNA DSB repair and suggests that targeting ALDOA …
DNA damage was shown to be elevated in ALDOA-depleted cells prior to IR and following IR the damage was repaired more slowly. ...Toge …
Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome.
Wan N, Wang N, Yu S, Zhang H, Tang S, Wang D, Lu W, Li H, Delafield DG, Kong Y, Wang X, Shao C, Lv L, Wang G, Tan R, Wang N, Hao H, Ye H. Wan N, et al. Nat Methods. 2022 Jul;19(7):854-864. doi: 10.1038/s41592-022-01523-1. Epub 2022 Jun 27. Nat Methods. 2022. PMID: 35761067
Specifically, by mining the public human Meltome Atlas, we found that lactylation is common on glycolytic enzymes and conserved on ALDOA. We also discovered prevalent lactylation on DHRS7 in the draft of the human tissue proteome. We partially demonstrated the functional i …
Specifically, by mining the public human Meltome Atlas, we found that lactylation is common on glycolytic enzymes and conserved on ALDOA …
ALDOA protects cardiomyocytes against H/R-induced apoptosis and oxidative stress by regulating the VEGF/Notch 1/Jagged 1 pathway.
Luo G, Wang R, Zhou H, Liu X. Luo G, et al. Mol Cell Biochem. 2021 Feb;476(2):775-783. doi: 10.1007/s11010-020-03943-z. Epub 2020 Oct 21. Mol Cell Biochem. 2021. PMID: 33089381
ALDOA was expressed at a low level in blood samples from MI patients and H/R-induced H9C2 cardiomyocytes. Overexpression of ALDOA suppressed H/R-induced oxidative stress and apoptosis. Using co-immunoprecipitation and protein blots, we demonstrated that ALDOA …
ALDOA was expressed at a low level in blood samples from MI patients and H/R-induced H9C2 cardiomyocytes. Overexpression of ALDOA …
Prognostic Implications and Immune Infiltration Analysis of ALDOA in Lung Adenocarcinoma.
Lu G, Shi W, Zhang Y. Lu G, et al. Front Genet. 2021 Dec 3;12:721021. doi: 10.3389/fgene.2021.721021. eCollection 2021. Front Genet. 2021. PMID: 34925439 Free PMC article.
Background: aldolase A (ALDOA) has been reported to be involved in kinds of cancers. However, the role of ALDOA in lung adenocarcinoma has not been fully elucidated. In this study, we explored the prognostic value and correlation with immune infiltration of ALDOA …
Background: aldolase A (ALDOA) has been reported to be involved in kinds of cancers. However, the role of ALDOA in lung adenoc …
ALDOA functions as an oncogene in the highly metastatic pancreatic cancer.
Ji S, Zhang B, Liu J, Qin Y, Liang C, Shi S, Jin K, Liang D, Xu W, Xu H, Wang W, Wu C, Liu L, Liu C, Xu J, Ni Q, Yu X. Ji S, et al. Cancer Lett. 2016 Apr 28;374(1):127-135. doi: 10.1016/j.canlet.2016.01.054. Epub 2016 Feb 12. Cancer Lett. 2016. PMID: 26854714
Subsequent analysis indicated that among glycolytic genes, aldolase A (ALDOA) increased the most significantly upon TGF-beta treatment. ...Moreover, ALDOA predicted poor prognosis of pancreatic cancer, partially due to its role in E-cadherin expression regulation, a …
Subsequent analysis indicated that among glycolytic genes, aldolase A (ALDOA) increased the most significantly upon TGF-beta treatmen …
305 results