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PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.
Salvi A, Young AN, Huntsman AC, Pergande MR, Korkmaz MA, Rathnayake RA, Mize BK, Kinghorn AD, Zhang X, Ratia K, Schirle M, Thomas JR, Brittain SM, Shelton C, Aldrich LN, Cologna SM, Fuchs JR, Burdette JE. Salvi A, et al. Among authors: aldrich ln. Cell Death Dis. 2022 Jan 10;13(1):45. doi: 10.1038/s41419-021-04495-w. Cell Death Dis. 2022. PMID: 35013112 Free PMC article.
Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition.
Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, Aldrich LN, Fuchs JR, Burdette JE. Young AN, et al. Among authors: aldrich ln. Mol Cancer Ther. 2018 Oct;17(10):2123-2135. doi: 10.1158/1535-7163.MCT-17-1195. Epub 2018 Jul 17. Mol Cancer Ther. 2018. PMID: 30018048 Free PMC article.
Discovery of Anticancer Agents of Diverse Natural Origin.
Aldrich LN, Burdette JE, Carcache de Blanco E, Coss CC, Eustaquio AS, Fuchs JR, Kinghorn AD, MacFarlane A, Mize BK, Oberlies NH, Orjala J, Pearce CJ, Phelps MA, Rakotondraibe LH, Ren Y, Soejarto DD, Stockwell BR, Yalowich JC, Zhang X. Aldrich LN, et al. J Nat Prod. 2022 Mar 25;85(3):702-719. doi: 10.1021/acs.jnatprod.2c00036. Epub 2022 Feb 25. J Nat Prod. 2022. PMID: 35213158 Free PMC article.
Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models.
Maldonado AC, Haughan MA, Khin M, Ekiert J, Zhang Z, Lantvit D, Al Subeh ZY, Pierre HC, Salkovski M, Hirschhorn T, Gao Y, Pearce CJ, Stockwell BR, Aldrich LN, Oberlies NH, Burdette JE. Maldonado AC, et al. Among authors: aldrich ln. J Nat Prod. 2023 Sep 22;86(9):2102-2110. doi: 10.1021/acs.jnatprod.3c00186. Epub 2023 Aug 29. J Nat Prod. 2023. PMID: 37643353
Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons.
Hippman RS, Snead AM, Petros ZA, Korkmaz-Vaisys MA, Patel S, Sotelo D, Dobria A, Salkovski M, Nguyen TTA, Linares R, Cologna SM, Gowrishankar S, Aldrich LN. Hippman RS, et al. Among authors: aldrich ln. ACS Chem Neurosci. 2023 Dec 20;14(24):4363-4382. doi: 10.1021/acschemneuro.3c00573. Epub 2023 Dec 9. ACS Chem Neurosci. 2023. PMID: 38069806 Free PMC article.
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