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The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.
Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E. Hoffmann FS, et al. Among authors: alexander t. J Immunol. 2015 Jan 15;194(2):542-52. doi: 10.4049/jimmunol.1402070. Epub 2014 Dec 10. J Immunol. 2015. PMID: 25505277 Free PMC article. Clinical Trial.
Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system.
Alexander T, Thiel A, Rosen O, Massenkeil G, Sattler A, Kohler S, Mei H, Radtke H, Gromnica-Ihle E, Burmester GR, Arnold R, Radbruch A, Hiepe F. Alexander T, et al. Blood. 2009 Jan 1;113(1):214-23. doi: 10.1182/blood-2008-07-168286. Epub 2008 Sep 29. Blood. 2009. PMID: 18824594 Free article. Clinical Trial.
The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus.
Alexander T, Sarfert R, Klotsche J, Kühl AA, Rubbert-Roth A, Lorenz HM, Rech J, Hoyer BF, Cheng Q, Waka A, Taddeo A, Wiesener M, Schett G, Burmester GR, Radbruch A, Hiepe F, Voll RE. Alexander T, et al. Ann Rheum Dis. 2015 Jul;74(7):1474-8. doi: 10.1136/annrheumdis-2014-206016. Epub 2015 Feb 20. Ann Rheum Dis. 2015. PMID: 25710470 Free PMC article. Clinical Trial.
γ-Secretase directly sheds the survival receptor BCMA from plasma cells.
Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E. Laurent SA, et al. Among authors: alexander t. Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333. Nat Commun. 2015. PMID: 26065893 Free PMC article.
999 results