Allen KL - Search Results

1

Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models.

Nicolas CT, Hickey RD, Allen KL, Du Z, Guthman RM, Kaiser RA, Amiot B, Bansal A, Pandey MK, Suksanpaisan L, DeGrado TR, Nyberg SL, Lillegard JB. Nicolas CT, et al. Among authors: allen kl. Surgery. 2018 Sep;164(3):473-481. doi: 10.1016/j.surg.2018.04.012. Epub 2018 Jun 6. Surgery. 2018. PMID: 29884476 Free PMC article.

2

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine.

Kaiser RA, Mao SA, Glorioso J, Amiot B, Nicolas CT, Allen KL, Du Z, VanLith CJ, Hickey RD, Nyberg SL, Lillegard JB. Kaiser RA, et al. Among authors: allen kl. J Vis Exp. 2018 Nov 4;(141):10.3791/58399. doi: 10.3791/58399. J Vis Exp. 2018. PMID: 30451238 Free PMC article.

3

Ex Vivo Hepatocyte Reprograming Promotes Homology-Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation.

VanLith CJ, Guthman RM, Nicolas CT, Allen KL, Liu Y, Chilton JA, Tritz ZP, Nyberg SL, Kaiser RA, Lillegard JB, Hickey RD. VanLith CJ, et al. Among authors: allen kl. Hepatol Commun. 2019 Feb 15;3(4):558-573. doi: 10.1002/hep4.1315. eCollection 2019 Apr. Hepatol Commun. 2019. PMID: 30976745 Free PMC article.

4

Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1.

VanLith C, Guthman R, Nicolas CT, Allen K, Du Z, Joo DJ, Nyberg SL, Lillegard JB, Hickey RD. VanLith C, et al. Hum Gene Ther. 2018 Nov;29(11):1315-1326. doi: 10.1089/hum.2017.252. Epub 2018 Jun 22. Hum Gene Ther. 2018. PMID: 29764210 Free PMC article.

5

Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1.

Hickey RD, Nicolas CT, Allen K, Mao S, Elgilani F, Glorioso J, Amiot B, VanLith C, Guthman R, Du Z, Chen H, Harding CO, Kaiser RA, Nyberg SL, Lillegard JB. Hickey RD, et al. Cell Transplant. 2019 Jan;28(1):79-88. doi: 10.1177/0963689718814188. Epub 2018 Nov 26. Cell Transplant. 2019. PMID: 30477316 Free PMC article.

6

Hepatotoxicity and Toxicology of In Vivo Lentiviral Vector Administration in Healthy and Liver-Injury Mouse Models.

Kaiser RA, Nicolas CT, Allen KL, Chilton JA, Du Z, Hickey RD, Lillegard JB. Kaiser RA, et al. Among authors: allen kl. Hum Gene Ther Clin Dev. 2019 Jun;30(2):57-66. doi: 10.1089/humc.2018.249. Epub 2019 Apr 11. Hum Gene Ther Clin Dev. 2019. PMID: 30860398 Free PMC article.

7

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure.

Nicolas CT, Kaiser RA, Hickey RD, Allen KL, Du Z, VanLith CJ, Guthman RM, Amiot B, Suksanpaisan L, Han B, Francipane MG, Cheikhi A, Jiang H, Bansal A, Pandey MK, Garg I, Lowe V, Bhagwate A, O'Brien D, Kocher JA, DeGrado TR, Nyberg SL, Lagasse E, Lillegard JB. Nicolas CT, et al. Among authors: allen kl. Mol Ther Methods Clin Dev. 2020 Jul 10;18:738-750. doi: 10.1016/j.omtm.2020.07.009. eCollection 2020 Sep 11. Mol Ther Methods Clin Dev. 2020. PMID: 32913881 Free PMC article.

8

Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.

Kaiser RA, Carlson DF, Allen KL, Webster DA, VanLith CJ, Nicolas CT, Hillin LG, Yu Y, Kaiser CW, Wahoff WR, Hickey RD, Watson AL, Winn SR, Thöny B, Kern DR, Harding CO, Lillegard JB. Kaiser RA, et al. Among authors: allen kl. PLoS One. 2021 Jan 25;16(1):e0245831. doi: 10.1371/journal.pone.0245831. eCollection 2021. PLoS One. 2021. PMID: 33493163 Free PMC article.

9

Use of an adeno-associated virus serotype Anc80 to provide durable cure of phenylketonuria in a mouse model.

Kaiser RA, Weber ND, Trigueros-Motos L, Allen KL, Martinez M, Cao W, VanLith CJ, Hillin LG, Douar A, González-Aseguinolaza G, Aldabe R, Lillegard JB. Kaiser RA, et al. Among authors: allen kl. J Inherit Metab Dis. 2021 Nov;44(6):1369-1381. doi: 10.1002/jimd.12392. Epub 2021 Aug 19. J Inherit Metab Dis. 2021. PMID: 33896013 Free PMC article.

10

Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections.

Rubin JD, Nguyen TV, Allen KL, Ayasoufi K, Barry MA. Rubin JD, et al. Among authors: allen kl. Hum Gene Ther. 2019 Dec;30(12):1559-1571. doi: 10.1089/hum.2019.127. Epub 2019 Dec 3. Hum Gene Ther. 2019. PMID: 31637925 Free PMC article.

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