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Pyridine-N-Oxide Alkaloids from Allium stipitatum and Their Synthetic Disulfide Analogs as Potential Drug Candidates against Mycobacterium tuberculosis: A Molecular Docking, QSBAR, and ADMET Prediction Approach.
Amengor CDK, Orman E, Danquah CA, Ben IO, Biniyam PD, Harley BK. Amengor CDK, et al. Biomed Res Int. 2022 Oct 7;2022:6261528. doi: 10.1155/2022/6261528. eCollection 2022. Biomed Res Int. 2022. PMID: 36246961 Free PMC article.
In this study, we consider pyridine-N-oxide alkaloids from Allium stipitatum and their synthetic disulfide analogs (PDAs) as candidates for next-generational antimycobacterial agents, in light of growing resistance to existing conventional therapies. ...
In this study, we consider pyridine-N-oxide alkaloids from Allium stipitatum and their synthetic disulfide analogs (PDAs) as c …
Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model.
Karunanidhi A, Ghaznavi-Rad E, Jeevajothi Nathan J, Abba Y, van Belkum A, Neela V. Karunanidhi A, et al. Evid Based Complement Alternat Med. 2017;2017:1914732. doi: 10.1155/2017/1914732. Epub 2017 Feb 22. Evid Based Complement Alternat Med. 2017. PMID: 28321262 Free PMC article.
The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistant Staphylococcus aureus (MRSA). ...
The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice …
Bioactive 2-(Methyldithio)Pyridine-3-Carbonitrile from Persian Shallot (Allium stipitatum Regel.) Exerts Broad-Spectrum Antimicrobial Activity.
Karunanidhi A, Ghaznavi-Rad E, Jeevajothi Nathan J, Joseph N, Chigurupati S, Mohd Fauzi F, Pichika MR, Hamat RA, Lung LTT, van Belkum A, Neela V. Karunanidhi A, et al. Molecules. 2019 Mar 13;24(6):1003. doi: 10.3390/molecules24061003. Molecules. 2019. PMID: 30871159 Free PMC article.
Herein is described the isolation and structure elucidation of a bioactive compound from Allium stipitatum with antimicrobial activity. Crude Allium stipitatum dichloromethane extract (ASDE) was subjected to systematic purification by chromatographic p …
Herein is described the isolation and structure elucidation of a bioactive compound from Allium stipitatum with antimicrobial …
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S. O'Donnell G, et al. J Nat Prod. 2009 Mar 27;72(3):360-5. doi: 10.1021/np800572r. J Nat Prod. 2009. PMID: 19093848 Free PMC article.
From Allium stipitatum, three pyridine-N-oxide alkaloids (1-3) possessing disulfide functional groups were isolated. ...Compounds 1 and 2 are new natural products, and 3 is reported for the first time from an Allium species. All compounds were evaluated for a …
From Allium stipitatum, three pyridine-N-oxide alkaloids (1-3) possessing disulfide functional groups were isolated. ...Compou …
Antifungal and antibiofilm activity of Persian shallot (Allium stipitatum Regel.) against clinically significant Candida spp.
Arunkumar K, Ehsanollah GR, Jayakayatri NJ, Fazlin MF, Leslie TLT, Mallikarjuna PR, Rukman AH, Vasanthakumari N. Arunkumar K, et al. Trop Biomed. 2018 Sep 1;35(3):815-825. Trop Biomed. 2018. PMID: 33601768 Free article.
Such a broad range of infections requires an equally broad range of therapeutic approach. Persian shallot (Allium stipitatum Regel.) is a medicinal plant that has been widely used in tradition Persian medicine for various ailments. Allium stipitatum is …
Such a broad range of infections requires an equally broad range of therapeutic approach. Persian shallot (Allium stipitatum R …
Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition.
Danquah CA, Kakagianni E, Khondkar P, Maitra A, Rahman M, Evangelopoulos D, McHugh TD, Stapleton P, Malkinson J, Bhakta S, Gibbons S. Danquah CA, et al. Sci Rep. 2018 Jan 18;8(1):1150. doi: 10.1038/s41598-017-18948-w. Sci Rep. 2018. PMID: 29348586 Free PMC article.
Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. ...
Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial proper …
Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum).
Krejčová P, Kučerová P, Stafford GI, Jäger AK, Kubec R. Krejčová P, et al. J Ethnopharmacol. 2014 May 28;154(1):176-82. doi: 10.1016/j.jep.2014.03.066. Epub 2014 Apr 8. J Ethnopharmacol. 2014. PMID: 24721027
ETHNOPHARMACOLOGICAL RELEVANCE: Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. ...Antiinflammatory and neurological activities of pyrithione and four related sulfur-containing pyridine N-oxides which are prominent con …
ETHNOPHARMACOLOGICAL RELEVANCE: Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia …
Antibacterial and Antibiofilm Activities of Nonpolar Extracts of Allium stipitatum Regel. against Multidrug Resistant Bacteria.
Karunanidhi A, Ghaznavi-Rad E, Hamat RA, Pichika MR, Lung LTT, Mohd Fauzi F, Chigurupati S, van Belkum A, Neela V. Karunanidhi A, et al. Biomed Res Int. 2018 Jul 11;2018:9845075. doi: 10.1155/2018/9845075. eCollection 2018. Biomed Res Int. 2018. PMID: 30105271 Free PMC article.
The present study assessed the in vitro antibacterial and antibiofilm potential of hexane (ASHE) and dichloromethane (ASDE) extracts of Allium stipitatum (Persian shallot) against planktonic cells and biofilm structures of clinically significant antibiotic resistant …
The present study assessed the in vitro antibacterial and antibiofilm potential of hexane (ASHE) and dichloromethane (ASDE) extracts of A …
Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum.
Kubec R, Krejcová P, Simek P, Václavík L, Hajslová J, Schraml J. Kubec R, et al. J Agric Food Chem. 2011 May 25;59(10):5763-70. doi: 10.1021/jf200704n. Epub 2011 Apr 29. J Agric Food Chem. 2011. PMID: 21510712
Two novel, structurally unusual cysteine derivatives were isolated from the bulbs of Allium stipitatum (Allium subg. Melanocrommyum) and shown to be S-(2-pyridyl)cysteine N-oxide and S-(2-pyridyl)glutathione N-oxide. ...The alliinase-mediated formation of pyr …
Two novel, structurally unusual cysteine derivatives were isolated from the bulbs of Allium stipitatum (Allium subg. Me …
Natural Antioxidants, Health Effects and Bioactive Properties of Wild Allium Species.
Petropoulos SA, Di Gioia F, Polyzos N, Tzortzakis N. Petropoulos SA, et al. Curr Pharm Des. 2020;26(16):1816-1837. doi: 10.2174/1381612826666200203145851. Curr Pharm Des. 2020. PMID: 32013820 Review.
OBJECTIVE: The present review aims to unravel the chemical composition of wild Allium species and their healthrelated effects, focusing on the main antioxidant compounds. ...Considering the vast number of species, this review is divided into subsections where the most stud …
OBJECTIVE: The present review aims to unravel the chemical composition of wild Allium species and their healthrelated effects, focusi …
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