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Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.
Mashiyama ST, Malabanan MM, Akiva E, Bhosle R, Branch MC, Hillerich B, Jagessar K, Kim J, Patskovsky Y, Seidel RD, Stead M, Toro R, Vetting MW, Almo SC, Armstrong RN, Babbitt PC. Mashiyama ST, et al. Among authors: almo sc. PLoS Biol. 2014 Apr 22;12(4):e1001843. doi: 10.1371/journal.pbio.1001843. eCollection 2014 Apr. PLoS Biol. 2014. PMID: 24756107 Free PMC article.
Structure-guided discovery of new deaminase enzymes.
Hitchcock DS, Fan H, Kim J, Vetting M, Hillerich B, Seidel RD, Almo SC, Shoichet BK, Sali A, Raushel FM. Hitchcock DS, et al. Among authors: almo sc. J Am Chem Soc. 2013 Sep 18;135(37):13927-33. doi: 10.1021/ja4066078. Epub 2013 Sep 4. J Am Chem Soc. 2013. PMID: 23968233 Free PMC article.
Discovery of new enzymes and metabolic pathways by using structure and genome context.
Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP. Zhao S, et al. Among authors: almo sc. Nature. 2013 Oct 31;502(7473):698-702. doi: 10.1038/nature12576. Epub 2013 Sep 22. Nature. 2013. PMID: 24056934 Free PMC article.
Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup.
Wichelecki DJ, Balthazor BM, Chau AC, Vetting MW, Fedorov AA, Fedorov EV, Lukk T, Patskovsky YV, Stead MB, Hillerich BS, Seidel RD, Almo SC, Gerlt JA. Wichelecki DJ, et al. Among authors: almo sc. Biochemistry. 2014 Apr 29;53(16):2722-31. doi: 10.1021/bi500264p. Epub 2014 Apr 15. Biochemistry. 2014. PMID: 24697546 Free PMC article.
401 results