AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins.
Shi G, Scott H, Azhar NIFM, Gialeli A, Clennell B, Lee KS, Hurcombe J, Whitcomb D, Coward R, Wong LF, Cordero-Llana O, Uney JB.
Shi G, et al.
Sci Rep. 2023 May 23;13(1):8334. doi: 10.1038/s41598-023-35480-2.
Sci Rep. 2023.
PMID: 37221196
Free PMC article.
To investigate the actions of this class of drug further, we compared the ability of kenpaullone, alsterpaullone, 1-azakenapaullone, AZD5438, AT7519 (CDK and GSK-3a/b inhibitors) and dexpramipexole and olesoxime (mitochondrial permeability transition pore inhibitors) to pr …
To investigate the actions of this class of drug further, we compared the ability of kenpaullone, alsterpaullone, 1-azakenapaullone, …