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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 2
2002 1
2003 5
2004 6
2005 3
2006 7
2007 9
2009 3
2010 10
2011 5
2012 2
2013 5
2014 1
2015 2
2016 1
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2019 6
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77 results

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Page 1
Identification of important genes related to anoikis in acute myocardial infarction.
Song P, Yakufujiang Y, Zhou J, Gu S, Wang W, Huo Z. Song P, et al. J Cell Mol Med. 2024 Apr;28(8):e18264. doi: 10.1111/jcmm.18264. J Cell Mol Med. 2024. PMID: 38526027 Free PMC article.
IL1B were correlated with macrophages, mast cells, neutrophils and Tcells in MI, and the most common predicted medications were roxithromycin, NSC267099 and alsterpaullone. This study identified key genes associated with AMI and anoikis, highlighting their role in immune i …
IL1B were correlated with macrophages, mast cells, neutrophils and Tcells in MI, and the most common predicted medications were roxithromyci …
AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins.
Shi G, Scott H, Azhar NIFM, Gialeli A, Clennell B, Lee KS, Hurcombe J, Whitcomb D, Coward R, Wong LF, Cordero-Llana O, Uney JB. Shi G, et al. Sci Rep. 2023 May 23;13(1):8334. doi: 10.1038/s41598-023-35480-2. Sci Rep. 2023. PMID: 37221196 Free PMC article.
To investigate the actions of this class of drug further, we compared the ability of kenpaullone, alsterpaullone, 1-azakenapaullone, AZD5438, AT7519 (CDK and GSK-3a/b inhibitors) and dexpramipexole and olesoxime (mitochondrial permeability transition pore inhibitors) to pr …
To investigate the actions of this class of drug further, we compared the ability of kenpaullone, alsterpaullone, 1-azakenapaullone, …
Computational Drug Repurposing for Alzheimer's Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies.
Xu Y, Kong J, Hu P. Xu Y, et al. Front Pharmacol. 2021 Jun 30;12:617537. doi: 10.3389/fphar.2021.617537. eCollection 2021. Front Pharmacol. 2021. PMID: 34276354 Free PMC article.
Our analysis identified eight AD candidate drugs (ellipticine, alsterpaullone, tomelukast, ginkgolide A, chrysin, ouabain, sulindac sulfide and lorglumide), four of which (alsterpaullone, ginkgolide A, chrysin and ouabain) have shown repurposing potential for AD val …
Our analysis identified eight AD candidate drugs (ellipticine, alsterpaullone, tomelukast, ginkgolide A, chrysin, ouabain, sulindac s …
Glycogen Synthase Kinase 3β Inhibitor Delivered by Chitosan Nanocapsules Promotes Safe, Fast, and Efficient Activation of Wnt Signaling In Vivo.
Ambrosone A, Matteis L, Serrano-Sevilla I, Tortiglione C, De La Fuente JM. Ambrosone A, et al. ACS Biomater Sci Eng. 2020 May 11;6(5):2893-2903. doi: 10.1021/acsbiomaterials.9b01820. Epub 2020 Apr 8. ACS Biomater Sci Eng. 2020. PMID: 33463287
In this study, oily core chitosan nanocapsules were designed with the aim to deliver the Wnt signaling agonist alsterpaullone in the model organism Hydra vulgaris. Chitosan nanocapsules show negligible impact on animal morphology, without affecting the viability. Nile red- …
In this study, oily core chitosan nanocapsules were designed with the aim to deliver the Wnt signaling agonist alsterpaullone in the …
Differential expression of BMP inhibitors gremlin and noggin in Hydra suggests distinct roles during budding and patterning of tentacles.
Krishnapati LS, Khade S, Trimbake D, Patwardhan R, Nadimpalli SK, Ghaskadbi S. Krishnapati LS, et al. Dev Dyn. 2020 Dec;249(12):1470-1485. doi: 10.1002/dvdy.238. Epub 2020 Sep 9. Dev Dyn. 2020. PMID: 33245611 Free article.
This was confirmed in ectopic tentacles in polyps treated with alsterpaullone (ALP), a GSK-3beta inhibitor that leads to upregulation of Wnt pathway. ...
This was confirmed in ectopic tentacles in polyps treated with alsterpaullone (ALP), a GSK-3beta inhibitor that leads to upregulation …
Bacteria- and temperature-regulated peptides modulate β-catenin signaling in Hydra.
Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TCG, Fraune S. Taubenheim J, et al. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21459-21468. doi: 10.1073/pnas.2010945117. Epub 2020 Aug 19. Proc Natl Acad Sci U S A. 2020. PMID: 32817436 Free PMC article.
In Hydra, formation of the head organizer involves the canonical Wnt pathway. Treatment with alsterpaullone (ALP) results in acquiring characteristics of the head organizer in the body column. ...
In Hydra, formation of the head organizer involves the canonical Wnt pathway. Treatment with alsterpaullone (ALP) results in acquirin …
RNA-Sequencing, Connectivity Mapping, and Molecular Docking to Investigate Ligand-Protein Binding for Potential Drug Candidates for the Treatment of Wilms Tumor.
Luo JY, Yan SB, Chen G, Chen P, Liang SW, Xu QQ, Gu JH, Huang ZG, Qin LT, Lu HP, Mo WJ, Luo YG, Chen JB. Luo JY, et al. Med Sci Monit. 2020 Mar 26;26:e920725. doi: 10.12659/MSM.920725. Med Sci Monit. 2020. PMID: 32214060 Free PMC article.
Molecular docking results showed that relatively high scores were obtained when retinoic acid and the cyclin-dependent kinase inhibitor, alsterpaullone, were docked to the overlapping genes. There were significant standardized mean differences for three overlapping genes, …
Molecular docking results showed that relatively high scores were obtained when retinoic acid and the cyclin-dependent kinase inhibitor, …
Antitumor activity of cyclin-dependent kinase inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders.
Watanabe T, Sato Y, Masud HMAA, Takayama M, Matsuda H, Hara Y, Yanagi Y, Yoshida M, Goshima F, Murata T, Kimura H. Watanabe T, et al. Cancer Sci. 2020 Jan;111(1):279-287. doi: 10.1111/cas.14241. Epub 2019 Dec 11. Cancer Sci. 2020. PMID: 31743514 Free PMC article.
In this study, we examined whether CDK inhibitors confer a therapeutic effect against LPDs in vivo. Treatment with alsterpaullone, an inhibitor of the CDK2 complex, resulted in a survival benefit and suppressed tumor invasion in a mouse model of LPDs. Inhibition of CDK eff …
In this study, we examined whether CDK inhibitors confer a therapeutic effect against LPDs in vivo. Treatment with alsterpaullone, an …
Coordinated DNA Methylation and Gene Expression Data for Identification of the Critical Genes Associated with Childhood Atopic Asthma.
Shi K, Ge MN, Chen XQ. Shi K, et al. J Comput Biol. 2020 Jan;27(1):109-120. doi: 10.1089/cmb.2019.0194. Epub 2019 Aug 28. J Comput Biol. 2020. PMID: 31460781
Analysis of miRNA-target gene network showed that hsa-miR-148b had the highest number of target genes(degree = 21). Besides, we found that Alsterpaullone had a correlation value closest to -1 (correlation = -0.884, p = 0.0031), which indicated that the agent might be consi …
Analysis of miRNA-target gene network showed that hsa-miR-148b had the highest number of target genes(degree = 21). Besides, we found that …
77 results