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Year Number of Results
1982 2
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1988 4
1989 4
1990 3
1991 10
1992 6
1993 12
1994 11
1995 9
1996 6
1997 4
1998 5
1999 1
2000 2
2001 4
2002 2
2004 2
2005 2
2007 7
2008 7
2009 8
2010 7
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2017 7
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2020 4
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2023 8
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199 results

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Page 1
Rational design and synthesis of triazene-amonafide derivatives as novel potential antitumor agents causing oxidative damage towards DNA through intercalation mode.
Sun P, Xu N, Zhang X, Gao YF, Zhang JY, Zhang QM, Liang C, Yu RL, Xia YM, Gao WW. Sun P, et al. Bioorg Chem. 2024 Mar;144:107141. doi: 10.1016/j.bioorg.2024.107141. Epub 2024 Jan 18. Bioorg Chem. 2024. PMID: 38244381
In this work, we rationally designed and synthesized two novel triazene-amonafide derivatives 2-(2-(diisopropylamino)ethyl)-5-(3,3-dimethyltriaz-1-en-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (D-11) and 5-(3,3-diethyltriaz-1-en-1-yl)-2-(2-(diisopropylamino)ethyl)-1H-ben …
In this work, we rationally designed and synthesized two novel triazene-amonafide derivatives 2-(2-(diisopropylamino)ethyl)-5-(3,3-di …
Comprehensive Profiling and Therapeutic Insights into Differentially Expressed Genes in Hepatocellular Carcinoma.
Caputo WL, de Souza MC, Basso CR, Pedrosa VA, Seiva FRF. Caputo WL, et al. Cancers (Basel). 2023 Nov 30;15(23):5653. doi: 10.3390/cancers15235653. Cancers (Basel). 2023. PMID: 38067357 Free PMC article.
Potential therapeutic chemicals are alvocidib, AT-7519, kenpaullone, PHA-793887, JNJ-7706621, danusertibe, doxorubicin and analogues, mitoxantrone, podofilox, teniposide, and amonafide. Conclusion: This multi-omic study offers a comprehensive view of DEGs in HCC, shedding …
Potential therapeutic chemicals are alvocidib, AT-7519, kenpaullone, PHA-793887, JNJ-7706621, danusertibe, doxorubicin and analogues, mitoxa …
An Outlook of the Structure Activity Relationship (SAR) of Naphthalimide Derivatives as Anticancer Agents.
Bhat AA. Bhat AA. Anticancer Agents Med Chem. 2024;24(2):96-116. doi: 10.2174/0118715206274007231107094411. Anticancer Agents Med Chem. 2024. PMID: 37974443
Surprisingly, some derivatives demonstrate greater activity than the reference norms, such as cisplatin, amonafide, mitonafide and others and are selective against many cell lines. ...
Surprisingly, some derivatives demonstrate greater activity than the reference norms, such as cisplatin, amonafide, mitonafide and ot …
Discovery of 4-(N-dithiobenzyl piperazine)-1,8-naphthalimide as a potent multi-target antitumor agent with good efficacy, limited toxicity, and low resistance.
Liang SM, Liang GB, Wang HL, Jiang H, Ma XL, Wei JH, Huang RZ, Zhang Y. Liang SM, et al. Eur J Med Chem. 2024 Jan 5;263:115937. doi: 10.1016/j.ejmech.2023.115937. Epub 2023 Nov 10. Eur J Med Chem. 2024. PMID: 37972528
HepG-2, SKOV-3, and T24 xenograft assay results revealed that compounds 5j, 5k, and 6j exhibited good antitumor effects compared with amonafide. The pathology results indicated that compound 5j exhibited the least comprehensive toxicity among the three compounds, identifyi …
HepG-2, SKOV-3, and T24 xenograft assay results revealed that compounds 5j, 5k, and 6j exhibited good antitumor effects compared with amo …
Dual-Stimuli-Activatable Hybrid Prodrug for the Self-Immolative Delivery of an Anticancer Agent and Hydrogen Sulfide with Turn-On Fluorescence.
Sufian A, Badirujjaman M, Barman P, Bhabak KP. Sufian A, et al. Chemistry. 2023 Nov 24;29(66):e202302197. doi: 10.1002/chem.202302197. Epub 2023 Oct 17. Chemistry. 2023. PMID: 37665099
A carbamate-based prodrug AM-CB was also designed, capable of releasing the anticancer agent amonafide without any H(2) S. The prodrugs were synthesized using multi-step organic synthesis. ...While the prodrug AM-TCB retained the anticancer activity of free amonafide …
A carbamate-based prodrug AM-CB was also designed, capable of releasing the anticancer agent amonafide without any H(2) S. The prodru …
Amonafide Induces HUVEC Senescence by Inhibiting Autophagy.
Xia J, Zhou Y, He S, Vashisth MK, Jia H, Dai Q, He Y, Wang X. Xia J, et al. Discov Med. 2023 Jun;35(176):264-274. doi: 10.24976/Discov.Med.202335176.27. Discov Med. 2023. PMID: 37272093
Amonafide-induced cellular aging by inhibiting autophagy and activating the mTOR pathway. The findings may offer new strategies for managing adverse reactions to amonafide....
Amonafide-induced cellular aging by inhibiting autophagy and activating the mTOR pathway. The findings may offer new strategies for m …
Novel prognostic features and personalized treatment strategies for mitochondria-related genes in glioma patients.
Wu J, Zhou J, Chai Y, Qin C, Cai Y, Xu D, Lei Y, Mei Z, Li M, Shen L, Fang G, Yang Z, Cai S, Xiong N. Wu J, et al. Front Endocrinol (Lausanne). 2023 Apr 5;14:1172182. doi: 10.3389/fendo.2023.1172182. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37091853 Free PMC article.
Finally, using cellMiner database and molecular docking, it was confirmed that UQCRB binds covalently to Amonafide via lysine at position 78 and threonine at position 82, while cellular assays showed that Amonafide inhibits glioma migration and invasion. ...
Finally, using cellMiner database and molecular docking, it was confirmed that UQCRB binds covalently to Amonafide via lysine at posi …
Cysteine-responsive prodrug of the anti-cancer drug amonafide: fluorogenic adjuvant drug delivery with hydrogen sulfide (H(2)S).
Mahato SK, Barman P, Badirujjaman M, Bhabak KP. Mahato SK, et al. Chem Commun (Camb). 2023 Apr 18;59(32):4802-4805. doi: 10.1039/d3cc00220a. Chem Commun (Camb). 2023. PMID: 37000594
L-Cysteine (Cys)-responsive turn-on fluorogenic prodrug AM-ITC was developed for the adjuvant delivery of the anti-cancer drug amonafide and the gasotransmitter hydrogen sulfide (H(2)S) in aqueous and cellular media. ...
L-Cysteine (Cys)-responsive turn-on fluorogenic prodrug AM-ITC was developed for the adjuvant delivery of the anti-cancer drug amonafide …
Design, synthesis, and antitumor evaluation of morpholine substituted bisnaphthalimides as DNA targeting agents.
Chen XM, Zhou JY, Liu SQ, Song LH, Wang HL, Wang Q, Liang SM, Lu L, Wei JH, Huang R, Zhang Y. Chen XM, et al. Bioorg Med Chem Lett. 2023 Apr 1;85:129218. doi: 10.1016/j.bmcl.2023.129218. Epub 2023 Mar 7. Bioorg Med Chem Lett. 2023. PMID: 36894107
Some compounds exhibited relatively good antiproliferative activity on the cell lines tested, in comparison with mitonafide and amonafide. It is noteworthy that bisnaphthalimide A6 was identified as the most potent compound in anti-proliferation against MGC-803 cells, with …
Some compounds exhibited relatively good antiproliferative activity on the cell lines tested, in comparison with mitonafide and amonafide …
199 results