Structural insight into selectivity of amylin and calcitonin receptor agonists.
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM.
Cao J, et al.
Nat Chem Biol. 2024 Feb;20(2):162-169. doi: 10.1038/s41589-023-01393-4. Epub 2023 Aug 3.
Nat Chem Biol. 2024.
PMID: 37537379
This study explored potential tuning of peptide selectivity through modification to residues 19-22, resulting in a selective AMYR agonist, San385, as well as nonselective dual amylin and calcitonin receptor agonists (DACRAs), with San45 being an exemplar. We determined the struct …
This study explored potential tuning of peptide selectivity through modification to residues 19-22, resulting in a selective AMYR agonist, S …