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Page 1
Toxins 2017 conference in Madrid.
Albanese A, Cardoso F, Fujinaga Y, Jankovic J, Rummel A, Schiavo G. Albanese A, et al. Among authors: rummel a. Toxicon. 2018 Jun 1;147:1. doi: 10.1016/j.toxicon.2018.03.010. Epub 2018 Mar 20. Toxicon. 2018. PMID: 30837060 No abstract available.
Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.
Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindström M, Lista F, Lúquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC. Peck MW, et al. Among authors: rummel a. Toxins (Basel). 2017 Jan 18;9(1):38. doi: 10.3390/toxins9010038. Toxins (Basel). 2017. PMID: 28106761 Free PMC article. Review.
New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having …
New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges whe …
Medical aspects of toxin weapons.
Bigalke H, Rummel A. Bigalke H, et al. Among authors: rummel a. Toxicology. 2005 Oct 30;214(3):210-20. doi: 10.1016/j.tox.2005.06.015. Epub 2005 Aug 8. Toxicology. 2005. PMID: 16087285 Review.
For centuries, poisons and other biological material have been considered as weapons. However, it has been merely 100 years that the use of biological toxins as weapons has been explored scientifically. ...It is not only the median lethal dose of each toxi …
For centuries, poisons and other biological material have been considered as weapons. However, it has been merely 100 years that the …
Cell entry strategy of clostridial neurotoxins.
Binz T, Rummel A. Binz T, et al. Among authors: rummel a. J Neurochem. 2009 Jun;109(6):1584-95. doi: 10.1111/j.1471-4159.2009.06093.x. Epub 2009 Apr 28. J Neurochem. 2009. PMID: 19457120 Free article. Review.
This review summarizes the present knowledge about the cell receptor molecules and the mode of toxin-receptor interaction that enables the toxins' sophisticated access to their site of action....
This review summarizes the present knowledge about the cell receptor molecules and the mode of toxin-receptor interaction that enable …
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry.
Joensuu M, Syed P, Saber SH, Lanoue V, Wallis TP, Rae J, Blum A, Gormal RS, Small C, Sanders S, Jiang A, Mahrhold S, Krez N, Cousin MA, Cooper-White R, Cooper-White JJ, Collins BM, Parton RG, Balistreri G, Rummel A, Meunier FA. Joensuu M, et al. Among authors: rummel a. EMBO J. 2023 Jul 3;42(13):e112095. doi: 10.15252/embj.2022112095. Epub 2023 May 25. EMBO J. 2023. PMID: 37226896 Free PMC article.
We reveal that BoNT/A simultaneously interacts with a preassembled PSG-synaptotagmin-1 (Syt1) complex and SV2 on the neuronal plasma membrane, facilitating Syt1-SV2 nanoclustering that controls endocytic sorting of the toxin into synaptic vesicles. Syt1 CRISPRi knockdown s …
We reveal that BoNT/A simultaneously interacts with a preassembled PSG-synaptotagmin-1 (Syt1) complex and SV2 on the neuronal plasma membran …
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1.
Schenke M, Prause HC, Bergforth W, Przykopanski A, Rummel A, Klawonn F, Seeger B. Schenke M, et al. Among authors: rummel a. Toxins (Basel). 2021 Aug 22;13(8):585. doi: 10.3390/toxins13080585. Toxins (Basel). 2021. PMID: 34437455 Free PMC article.
The application of botulinum neurotoxins (BoNTs) for medical treatments necessitates a potency quantification of these lethal bacterial toxins, resulting in the use of a large number of test animals. Available alternative methods are limited in their relevance, as they are …
The application of botulinum neurotoxins (BoNTs) for medical treatments necessitates a potency quantification of these lethal bacterial t …
Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid.
Nowakowska MB, Selby K, Przykopanski A, Krüger M, Krez N, Dorner BG, Dorner MB, Jin R, Minton NP, Rummel A, Lindström M. Nowakowska MB, et al. Among authors: rummel a. Sci Rep. 2022 Feb 2;12(1):1790. doi: 10.1038/s41598-022-05008-1. Sci Rep. 2022. PMID: 35110559 Free PMC article.
Despite causing a life-threatening disease, BoNT is a multipurpose therapeutic. Nevertheless, as the most potent natural toxin, BoNT is classified as a Select Agent in the US, placing C. botulinum research under stringent governmental regulations. ...The resulting Beluga E …
Despite causing a life-threatening disease, BoNT is a multipurpose therapeutic. Nevertheless, as the most potent natural toxin, BoNT …
64 results