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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 1
1997 2
1998 6
1999 10
2000 22
2001 40
2002 36
2003 50
2004 62
2005 69
2006 82
2007 83
2008 100
2009 112
2010 121
2011 114
2012 137
2013 150
2014 120
2015 138
2016 175
2017 140
2018 115
2019 135
2020 155
2021 180
2022 149
2023 147
2024 44

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2,382 results

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Page 1
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression.
Korhonen EA, Murtomäki A, Jha SK, Anisimov A, Pink A, Zhang Y, Stritt S, Liaqat I, Stanczuk L, Alderfer L, Sun Z, Kapiainen E, Singh A, Sultan I, Lantta A, Leppänen VM, Eklund L, He Y, Augustin HG, Vaahtomeri K, Saharinen P, Mäkinen T, Alitalo K. Korhonen EA, et al. J Clin Invest. 2022 Aug 1;132(15):e155478. doi: 10.1172/JCI155478. J Clin Invest. 2022. PMID: 35763346 Free PMC article.
Neonatal deletion of genes encoding the Tie receptors or Ang2 in LECs, or administration of an Ang2-blocking Ab decreased VEGFR3 presentation on LECs and inhibited lymphangiogenesis. A similar effect was observed in LECs upon deletion of the PI3K catalytic p110alpha …
Neonatal deletion of genes encoding the Tie receptors or Ang2 in LECs, or administration of an Ang2-blocking Ab decreased VEGF …
Ang2-Targeted Combination Therapy for Cancer Treatment.
Liu N, Liu M, Fu S, Wang J, Tang H, Isah AD, Chen D, Wang X. Liu N, et al. Front Immunol. 2022 Jul 8;13:949553. doi: 10.3389/fimmu.2022.949553. eCollection 2022. Front Immunol. 2022. PMID: 35874764 Free PMC article. Review.
It has been proved that blocking Ang2 can inhibit the growth, invasion and metastasis of cancer cells. ...At the same time, the importance of Ang2 in cancer growth, metastasis, prognosis and combination therapy is pointed out. ...
It has been proved that blocking Ang2 can inhibit the growth, invasion and metastasis of cancer cells. ...At the same time, the impor …
Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology.
Akwii RG, Sajib MS, Zahra FT, Mikelis CM. Akwii RG, et al. Cells. 2019 May 17;8(5):471. doi: 10.3390/cells8050471. Cells. 2019. PMID: 31108880 Free PMC article. Review.
Recent data demonstrates that Ang2 has context-dependent agonist activities. Ang2 plays important roles in physiological processes and the deregulation of its expression is characteristic of several diseases. In this review, we summarize the activity of Ang2 …
Recent data demonstrates that Ang2 has context-dependent agonist activities. Ang2 plays important roles in physiological proce …
Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.
Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ. Reilly JP, et al. Intensive Care Med. 2018 Nov;44(11):1849-1858. doi: 10.1007/s00134-018-5328-0. Epub 2018 Oct 21. Intensive Care Med. 2018. PMID: 30343317 Free PMC article.
We then used linear regression and post-estimation analysis to genetically predict plasma ANG2 and tested genetically predicted ANG2 for ARDS association using logistic regression. ...Plasma ANG2 may be a causal factor in ARDS development. Strategies to reduc …
We then used linear regression and post-estimation analysis to genetically predict plasma ANG2 and tested genetically predicted AN …
Newly-established in vitro inner BRB spheroids to elucidate retinal Ang2-linked substance transfer.
Yamamoto Y, Akanuma SI, Kon H, Endo H, Kubo Y, Hosoya KI. Yamamoto Y, et al. J Control Release. 2022 Nov;351:8-21. doi: 10.1016/j.jconrel.2022.09.019. Epub 2022 Sep 19. J Control Release. 2022. PMID: 36122894
After intravenous administration of Ang2-linked green fluorescence protein (GFP-Ang2) in mice, GFP-derived signals were observed in the neural retina. ...In the inner BRB spheroids, energy-dependent accumulation of GFP-Ang2 and Ang2-linked 5(6)-carboxy …
After intravenous administration of Ang2-linked green fluorescence protein (GFP-Ang2) in mice, GFP-derived signals were observ …
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas.
Hosaka K, Andersson P, Wu J, He X, Du Q, Jing X, Seki T, Gao J, Zhang Y, Sun X, Huang P, Yang Y, Ge M, Cao Y. Hosaka K, et al. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2303740120. doi: 10.1073/pnas.2303740120. Epub 2023 Jul 10. Proc Natl Acad Sci U S A. 2023. PMID: 37428914 Free PMC article.
Mechanistically, KRAS mutations up-regulated the FOXC2 transcription factor that directly elevated ANG2 expression at the transcriptional level. ANG2 bestowed anti-VEGF resistance as an alternative pathway to augment VEGF-independent tumor angiogenesis. Most colorec …
Mechanistically, KRAS mutations up-regulated the FOXC2 transcription factor that directly elevated ANG2 expression at the transcripti …
Interfering growth of malignant melanoma with Ang2-siRNA.
Wang B, Liu Z, Zhang M, San X, Zhang Y, Zhang W, Wang M. Wang B, et al. Mol Biol Rep. 2013 Feb;40(2):1463-71. doi: 10.1007/s11033-012-2189-4. Epub 2012 Nov 16. Mol Biol Rep. 2013. PMID: 23160899 Free PMC article.
To investigate the intervention therapy effect on the growth of malignant melanoma, we have made an observation of expression levels of Ang2 in malignant melanoma cells, which was transduced by small interfering RNA (Ang2-siRNA) of Ang2 in vitro and in vivo. …
To investigate the intervention therapy effect on the growth of malignant melanoma, we have made an observation of expression levels of A …
Construction of Ang2-siRNA chitosan magnetic nanoparticles and the effect on Ang2 gene expression in human malignant melanoma cells.
Liu ZL, You CL, Wang B, Lin JH, Hu XF, Shan XY, Wang MS, Zheng HB, Zhang YD. Liu ZL, et al. Oncol Lett. 2016 Jun;11(6):3992-3998. doi: 10.3892/ol.2016.4539. Epub 2016 May 6. Oncol Lett. 2016. PMID: 27313729 Free PMC article.
The aim of the present study was to construct angiopoietin-2 (Ang2)-small interfering (si)RNA chitosan magnetic nanoparticles and to observe the interference effects of the nanoparticles on the expression of the Ang2 gene in human malignant melanoma cells. ...Ang …
The aim of the present study was to construct angiopoietin-2 (Ang2)-small interfering (si)RNA chitosan magnetic nanoparticles and to …
Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency.
Chatterjee A, Eshwaran R, Huang H, Zhao D, Schmidt M, Wieland T, Feng Y. Chatterjee A, et al. Int J Mol Sci. 2020 May 25;21(10):3713. doi: 10.3390/ijms21103713. Int J Mol Sci. 2020. PMID: 32466219 Free PMC article.
Similar to HG, however, NDPK-B depletion reduced Tie2 tyrosine phosphorylation. Compared to HG, a stronger increase of Ang2 was observed in NDPK-B depleted ECs. Treatment of ECs with soluble Tie2 or siRNA-mediated Tie2 knockdown attenuated NDPK-B depletion- but not HG-indu …
Similar to HG, however, NDPK-B depletion reduced Tie2 tyrosine phosphorylation. Compared to HG, a stronger increase of Ang2 was obser …
IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis.
Jiang S, Li Y, Lin T, Yuan L, Li Y, Wu S, Xia L, Shen H, Lu J. Jiang S, et al. Cell Physiol Biochem. 2016;40(5):1105-1116. doi: 10.1159/000453165. Epub 2016 Dec 14. Cell Physiol Biochem. 2016. PMID: 27960151 Free article.
Blocking the Ang/Tie2 pathway with a Tie2 kinase antibody inhibited the proangiogenic effects of exogenous Ang2 and VEGF in HUVECs. IL-35 inhibited basal and VEGF-induced Ang2 secretion by HUVECs and RA synovial tissue explants; it also antagonized the proangiogenic …
Blocking the Ang/Tie2 pathway with a Tie2 kinase antibody inhibited the proangiogenic effects of exogenous Ang2 and VEGF in HUVECs. I …
2,382 results