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Balancing risk and benefit in venous thromboembolism trials: concept for a bivariate endpoint trial design and analytic approach.
Kittelson JM, Spyropoulos AC, Halperin JL, Kessler CM, Schulman S, Steg G, Turpie AG, Cutler NR, Hiatt WR, Goldenberg NA; Antithrombotic Trials Leadership and Steering (ATLAS) Group. Kittelson JM, et al. J Thromb Haemost. 2013 Aug;11(8):1443-8. doi: 10.1111/jth.12324. J Thromb Haemost. 2013. PMID: 23773172 Free PMC article. Review.
Bivariate evaluation of thromboembolism and bleeding in clinical trials of anticoagulants in patients with atrial fibrillation.
Kittelson JM, Steg PG, Halperin JL, Goldenberg NA, Schulman S, Spyropoulos AC, Kessler CM, Turpie AG, Cutler NR, Hiatt WR; Antithrombotic Trials Leadership and Steering (ATLAS) Group. Kittelson JM, et al. Thromb Haemost. 2016 Aug 30;116(3):544-53. doi: 10.1160/TH15-12-1000. Epub 2016 Jun 23. Thromb Haemost. 2016. PMID: 27346176