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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 2
2001 1
2002 1
2003 3
2004 2
2005 2
2006 1
2007 2
2008 3
2009 4
2010 2
2011 3
2012 1
2013 4
2014 3
2016 3
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2018 2
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2021 3
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2024 0

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48 results

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Page 1
Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T. Hara T, et al. Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4416-E4424. doi: 10.1073/pnas.1703171114. Epub 2017 May 15. Proc Natl Acad Sci U S A. 2017. PMID: 28507122 Free PMC article.
Here, we report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth. ...Administration of E-selectin-neutralizing antibody also abolished host APBA3-mediated metastatic formation. Thus, targeting APBA3 is useful …
Here, we report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth. ...Administration …
Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus.
Uematsu T, Fujita T, Nakaoka HJ, Hara T, Kobayashi N, Murakami Y, Seiki M, Sakamoto T. Uematsu T, et al. Sci Rep. 2016 Nov 24;6:37815. doi: 10.1038/srep37815. Sci Rep. 2016. PMID: 27883071 Free PMC article.
Studies have suggested that excessive activation of the host immune system including macrophages is responsible for the severe pathologies mediated by IFV infection. Here, we focused on the X11 protein family member Mint3/Apba3, known to promote ATP production via glycolys …
Studies have suggested that excessive activation of the host immune system including macrophages is responsible for the severe pathologies m …
Association of an APBA3 Missense Variant with Risk of Premature Ovarian Failure in the Korean Female Population.
Park J, Park Y, Koh I, Kim NK, Baek KH, Yun BS, Lee KJ, Song JY, Lee E, Kwack K. Park J, et al. J Pers Med. 2020 Oct 26;10(4):193. doi: 10.3390/jpm10040193. J Pers Med. 2020. PMID: 33114509 Free PMC article.
No rs55941146 minor allele homozygotes were present in either cases or controls. The APBA3 protein binds FIH-1 that inhibits hypoxia inducible factor-1alpha (HIF-1alpha). HIF-1alpha contributes to granulosa cell proliferation, which is crucial for ovarian follicle growth, …
No rs55941146 minor allele homozygotes were present in either cases or controls. The APBA3 protein binds FIH-1 that inhibits hypoxia …
DNA methylation of APBA3 and MCF2 in borderline personality disorder: Potential biomarkers for response to psychotherapy.
Knoblich N, Gundel F, Brückmann C, Becker-Sadzio J, Frischholz C, Nieratschker V. Knoblich N, et al. Eur Neuropsychopharmacol. 2018 Feb;28(2):252-263. doi: 10.1016/j.euroneuro.2017.12.010. Epub 2017 Dec 20. Eur Neuropsychopharmacol. 2018. PMID: 29274998
In the present study, we aimed to investigate the role of DNA methylation of APBA3 and MCF2 as possible biomarkers for treatment outcome in BPD, whilst validating the previous findings of differential DNA methylation in a cohort of 44 BPD patients and 44 well-matched healt …
In the present study, we aimed to investigate the role of DNA methylation of APBA3 and MCF2 as possible biomarkers for treatment outc …
Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock.
Hara T, Mimura K, Abe T, Shioi G, Seiki M, Sakamoto T. Hara T, et al. J Biol Chem. 2011 Sep 16;286(37):32542-51. doi: 10.1074/jbc.M111.271726. Epub 2011 Jul 21. J Biol Chem. 2011. PMID: 21778228 Free PMC article.
To demonstrate the physiological function of APBA3 in macrophages, we established Apba3(-/-) mice. The mutant mice presented no apparent gross phenotype but exhibited significant resistance against LPS-induced septic shock. ...Thus, we show cell type-specific regula …
To demonstrate the physiological function of APBA3 in macrophages, we established Apba3(-/-) mice. The mutant mice presented n …
Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein.
Tanahashi H, Tabira T. Tanahashi H, et al. Neuroreport. 1999 Aug 20;10(12):2575-8. doi: 10.1097/00001756-199908200-00025. Neuroreport. 1999. PMID: 10574372
The APBA3 was localized by the radiation hybrid mapping to chromosome 19. Determination of the APBA3 genome structure will facilitate the linkage analysis and search for mutations in the APBA3 in patients with Alzheimer's disease....
The APBA3 was localized by the radiation hybrid mapping to chromosome 19. Determination of the APBA3 genome structure will fac …
Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion.
Hara T, Mimura K, Seiki M, Sakamoto T. Hara T, et al. Biochem Biophys Res Commun. 2011 Sep 23;413(2):277-81. doi: 10.1016/j.bbrc.2011.08.085. Epub 2011 Aug 27. Biochem Biophys Res Commun. 2011. PMID: 21893028
Here, we used Apba3(-/-) macrophages to dissect the contribution of the proteolytic and the energy-boosting activities of MT1-MMP. The proteolytic activity of MT1-MMP was not affected by the lack of APBA3 in macrophages. Apba3(-/-) and Mmp14(-/-) macrophages …
Here, we used Apba3(-/-) macrophages to dissect the contribution of the proteolytic and the energy-boosting activities of MT1-MMP. Th …
Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice.
Hara T, Murakami Y, Seiki M, Sakamoto T. Hara T, et al. Biochem Biophys Res Commun. 2017 Aug 26;490(3):688-692. doi: 10.1016/j.bbrc.2017.06.102. Epub 2017 Jun 19. Biochem Biophys Res Commun. 2017. PMID: 28634075
Data from recent studies using transplantation models indicate that Mint3/APBA3 might promote breast cancer malignancy. However, whether Mint3 indeed contributes to tumor development, progression, or metastasis in vivo remains unclear. ...
Data from recent studies using transplantation models indicate that Mint3/APBA3 might promote breast cancer malignancy. However, whet …
Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer's disease.
Kant S, Stopa EG, Johanson CE, Baird A, Silverberg GD. Kant S, et al. Fluids Barriers CNS. 2018 Dec 12;15(1):34. doi: 10.1186/s12987-018-0120-7. Fluids Barriers CNS. 2018. PMID: 30541599 Free PMC article.
., interleukin IL1RL1, p = 0.00001) and potential neurodegenerative genes (e.g., amyloid precursor APBA3, p = 0.002) also implicate disturbed CP function. CONCLUSIONS: Because the altered expression of numerous transcripts in AD-CP help explain decreased CSF production in …
., interleukin IL1RL1, p = 0.00001) and potential neurodegenerative genes (e.g., amyloid precursor APBA3, p = 0.002) also implicate d …
48 results