Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T.
Hara T, et al.
Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4416-E4424. doi: 10.1073/pnas.1703171114. Epub 2017 May 15.
Proc Natl Acad Sci U S A. 2017.
PMID: 28507122
Free PMC article.
Here, we report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth. ...Administration of E-selectin-neutralizing antibody also abolished host APBA3-mediated metastatic formation. Thus, targeting APBA3 is useful …
Here, we report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth. ...Administration …