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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 1
1958 1
1963 3
1964 5
1965 6
1966 83
1967 95
1968 77
1969 64
1970 97
1971 122
1972 81
1973 66
1974 77
1975 112
1976 83
1977 16
1978 17
1979 27
1980 31
1981 32
1982 56
1983 56
1984 50
1985 61
1986 68
1987 56
1988 89
1989 101
1990 133
1991 161
1992 228
1993 271
1994 301
1995 282
1996 319
1997 326
1998 307
1999 316
2000 394
2001 433
2002 486
2003 473
2004 551
2005 581
2006 716
2007 735
2008 750
2009 778
2010 933
2011 1025
2012 1237
2013 1292
2014 1466
2015 1755
2016 2093
2017 2587
2018 3124
2019 3418
2020 4552
2021 5344
2022 5559
2023 5481
2024 2024

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46,734 results

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Page 1
Amyloid, APP, and Electrical Activity of the Brain.
Hefter D, Ludewig S, Draguhn A, Korte M. Hefter D, et al. Neuroscientist. 2020 Jun;26(3):231-251. doi: 10.1177/1073858419882619. Epub 2019 Nov 29. Neuroscientist. 2020. PMID: 31779518 Free PMC article. Review.
Much research on APP focusses on potential contributions to neurodegeneration, mostly based on mouse models with altered expression or mutated forms of APP. However, cumulative evidence from recent years indicates the indispensability of APP and its metabolit …
Much research on APP focusses on potential contributions to neurodegeneration, mostly based on mouse models with altered expression o …
APP as a Protective Factor in Acute Neuronal Insults.
Hefter D, Draguhn A. Hefter D, et al. Front Mol Neurosci. 2017 Feb 2;10:22. doi: 10.3389/fnmol.2017.00022. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28210211 Free PMC article. Review.
A key observation is the up-regulation of APP following acute (stroke, cardiac arrest) or chronic (cerebrovascular disease) hypoxic-ischemic conditions. ...In addition, APP affects the expression of survival- or apoptosis-related genes as well as neurotrophic factor …
A key observation is the up-regulation of APP following acute (stroke, cardiac arrest) or chronic (cerebrovascular disease) hypoxic-i …
APP-A Novel Player within the Presynaptic Active Zone Proteome.
Weingarten J, Weingarten M, Wegner M, Volknandt W. Weingarten J, et al. Front Mol Neurosci. 2017 Feb 20;10:43. doi: 10.3389/fnmol.2017.00043. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28265241 Free PMC article. Review.
The analysis of the hippocampal PAZ proteome derived from APP-mutant mice demonstrates that APP is tightly embedded in the underlying protein network. ...The observed changes in protein abundance that occur in the absence of APP as well as in AD suggest that …
The analysis of the hippocampal PAZ proteome derived from APP-mutant mice demonstrates that APP is tightly embedded in the und …
APP family member dimeric complexes are formed predominantly in synaptic compartments.
Schilling S, August A, Meleux M, Conradt C, Tremmel LM, Teigler S, Adam V, Müller UC, Koo EH, Kins S, Eggert S. Schilling S, et al. Cell Biosci. 2023 Aug 2;13(1):141. doi: 10.1186/s13578-023-01092-6. Cell Biosci. 2023. PMID: 37533067 Free PMC article.
BACKGROUND: The amyloid precursor protein (APP), a key player in Alzheimer's disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. ...Interestingly, only about 20% of APP is dimerized in cultured cells whereas up to 5 …
BACKGROUND: The amyloid precursor protein (APP), a key player in Alzheimer's disease (AD), is part of a larger gene family, including …
The Role of APP in Structural Spine Plasticity.
Montagna E, Dorostkar MM, Herms J. Montagna E, et al. Front Mol Neurosci. 2017 May 10;10:136. doi: 10.3389/fnmol.2017.00136. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28539872 Free PMC article. Review.
Furthermore, APP can be cleaved by several proteases into numerous fragments, many of which affect synaptic function and stability. This review article focuses on the mechanisms of APP in structural spine plasticity, which encompasses the morphological alterations a …
Furthermore, APP can be cleaved by several proteases into numerous fragments, many of which affect synaptic function and stability. T …
Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.
Wang X, Zhou X, Li G, Zhang Y, Wu Y, Song W. Wang X, et al. Front Mol Neurosci. 2017 Sep 15;10:294. doi: 10.3389/fnmol.2017.00294. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28966576 Free PMC article. Review.
Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid beta (Abeta) protein. Abeta is derived from amyloid precursor protein (APP) by sequential cleavages of beta- and gamma-secretase. Although APP upregulation can promote …
Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid beta (Abeta) protein. Abeta is derived fr …
Transcriptional and Post-Transcriptional Regulations of Amyloid-beta Precursor Protein (APP) mRNA.
Sato K, Takayama KI, Hashimoto M, Inoue S. Sato K, et al. Front Aging. 2021 Aug 11;2:721579. doi: 10.3389/fragi.2021.721579. eCollection 2021. Front Aging. 2021. PMID: 35822056 Free PMC article. Review.
Additionally, extra copies of the APP gene caused by chromosomal duplication in patients with Down syndrome can promote AD pathogenesis, indicating the pathological involvement of the APP gene dose in AD. Furthermore, increased APP expression due to locus dup …
Additionally, extra copies of the APP gene caused by chromosomal duplication in patients with Down syndrome can promote AD pathogenes …
Exosomes Mediate APP Dysregulation via APP-miR-185-5p Axis.
Ding L, Yang X, Xia X, Li Y, Wang Y, Li C, Sun Y, Gao G, Zhao S, Sheng S, Liu J, Zheng JC. Ding L, et al. Front Cell Dev Biol. 2022 Feb 11;10:793388. doi: 10.3389/fcell.2022.793388. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35223832 Free PMC article.
In this study, we found that the exosomes isolated from AD mouse brain promoted APP expression in neuronal N2a cells. Moreover, exosomes derived from N2a cells with ectopic expression of APP (APP-EXO) also induced APP dysregulation in normal N2a cells. …
In this study, we found that the exosomes isolated from AD mouse brain promoted APP expression in neuronal N2a cells. Moreover, exoso …
A Novel Method for Evaluating Mobile Apps (App Rating Inventory): Development Study.
Mackey R, Gleason A, Ciulla R. Mackey R, et al. JMIR Mhealth Uhealth. 2022 Apr 15;10(4):e32643. doi: 10.2196/32643. JMIR Mhealth Uhealth. 2022. PMID: 35436227 Free PMC article. Review.
RESULTS: The development phase culminated in a review of 248 apps for a total of 6944 data points and a final 28-item, 3-category app rating system. The App Rating Inventory produces scores for the following three categories: evidence (6 items), content (11 items), …
RESULTS: The development phase culminated in a review of 248 apps for a total of 6944 data points and a final 28-item, 3-category app …
Amyloid precursor protein (APP) and amyloid beta (Abeta) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology.
Pfundstein G, Nikonenko AG, Sytnyk V. Pfundstein G, et al. Front Cell Dev Biol. 2022 Jul 26;10:969547. doi: 10.3389/fcell.2022.969547. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35959488 Free PMC article. Review.
APP interacts with cell adhesion molecules, which influence the normal physiological functions of APP, its amyloidogenic and non-amyloidogenic processing, and formation of Abeta aggregates. ...In this review, we discuss the current knowledge surrounding the interact …
APP interacts with cell adhesion molecules, which influence the normal physiological functions of APP, its amyloidogenic and n …
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