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Year Number of Results
1799 6
1800 4
1801 6
1802 2
1803 2
1804 2
1805 2
1806 3
1807 3
1808 4
1809 3
1810 4
1811 3
1812 2
1813 2
1814 6
1817 1
1818 1
1820 1
1822 1
1823 3
1827 1
1828 1
1829 1
1830 3
1831 2
1832 1
1837 1
1838 2
1839 2
1840 1
1841 8
1842 3
1843 10
1844 2
1845 3
1846 1
1848 2
1849 2
1850 6
1851 2
1852 5
1853 5
1854 5
1855 7
1856 5
1857 7
1858 3
1859 3
1860 5
1861 5
1862 1
1864 8
1865 4
1866 4
1867 5
1868 4
1869 4
1870 3
1871 3
1872 4
1873 5
1874 4
1875 3
1876 3
1877 4
1879 7
1880 5
1881 4
1882 4
1883 9
1884 5
1885 20
1886 12
1887 12
1888 14
1889 12
1890 12
1891 12
1892 12
1893 15
1894 10
1895 15
1896 11
1897 14
1898 16
1899 11
1900 12
1901 14
1902 9
1903 11
1904 13
1905 13
1906 16
1907 13
1908 12
1909 10
1910 12
1911 11
1912 13
1913 10
1914 13
1915 16
1916 14
1917 10
1918 12
1919 10
1920 10
1921 12
1922 11
1923 8
1924 11
1925 12
1926 11
1927 14
1928 15
1929 11
1930 16
1931 13
1932 8
1933 12
1934 12
1935 14
1936 5
1937 6
1938 7
1939 6
1940 6
1941 7
1942 8
1943 7
1944 5
1945 7
1946 15
1947 19
1948 12
1949 6
1950 53
1951 97
1952 126
1953 120
1954 19
1955 36
1956 36
1957 25
1958 22
1959 19
1960 23
1961 22
1962 20
1963 34
1964 46
1965 46
1966 48
1967 63
1968 54
1969 55
1970 81
1971 65
1972 60
1973 92
1974 71
1975 179
1976 217
1977 179
1978 248
1979 280
1980 246
1981 231
1982 273
1983 363
1984 383
1985 472
1986 533
1987 599
1988 724
1989 948
1990 945
1991 966
1992 1014
1993 1156
1994 1253
1995 1334
1996 1385
1997 1387
1998 1565
1999 1715
2000 1804
2001 2010
2002 2260
2003 2533
2004 2748
2005 3062
2006 3385
2007 3592
2008 4043
2009 4461
2010 5015
2011 5683
2012 6351
2013 6940
2014 7573
2015 8167
2016 8993
2017 9590
2018 10342
2019 11666
2020 18843
2021 23095
2022 22277
2023 19837
2024 7941
2025 2

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The following term was not found in PubMed: Fitts-Cowley
Page 1
The BAFF-APRIL System in Cancer.
Ullah MA, Mackay F. Ullah MA, et al. Cancers (Basel). 2023 Mar 16;15(6):1791. doi: 10.3390/cancers15061791. Cancers (Basel). 2023. PMID: 36980677 Free PMC article. Review.
BAFF was initially discovered as a B-cell survival factor, whereas APRIL was first identified as a protein highly expressed in various cancers. ...We also highlight the emerging therapeutics targeting the BAFF-APRIL system in different cancer types....
BAFF was initially discovered as a B-cell survival factor, whereas APRIL was first identified as a protein highly expressed in variou …
Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases.
Samy E, Wax S, Huard B, Hess H, Schneider P. Samy E, et al. Int Rev Immunol. 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. Int Rev Immunol. 2017. PMID: 28215100 Free article. Review.
The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. ...As such, both molecules are rational targets for new therapies in B cell-drive …
The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors i …
TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6-mediated pathways in IgA nephropathy.
Makita Y, Suzuki H, Kano T, Takahata A, Julian BA, Novak J, Suzuki Y. Makita Y, et al. Kidney Int. 2020 Feb;97(2):340-349. doi: 10.1016/j.kint.2019.08.022. Epub 2019 Sep 5. Kidney Int. 2020. PMID: 31748116 Free PMC article.
CpG-oligonucleotide-stimulated mice had elevated serum levels of APRIL that correlated with those of aberrantly glycosylated IgA and IgG-IgA immune complexes. ...However, siRNA knock-down of APRIL completely suppressed overproduction of Gd-IgA1 induced by IL-6. ...
CpG-oligonucleotide-stimulated mice had elevated serum levels of APRIL that correlated with those of aberrantly glycosylated IgA and …
Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell-Related Autoimmune Diseases.
Evans LS, Lewis KE, DeMonte D, Bhandari JG, Garrett LB, Kuijper JL, Ardourel D, Wolfson MF, Debrot S, Mudri S, Kleist K, Griffin LL, Hebb L, Sanderson RJ, Wang N, Seaberg M, Chunyk AG, Yang J, Hong Y, Maria Z, Messenheimer DJ, Holland PM, Peng SL, Rixon MW, Dillon SR. Evans LS, et al. Arthritis Rheumatol. 2023 Jul;75(7):1187-1202. doi: 10.1002/art.42462. Epub 2023 Apr 19. Arthritis Rheumatol. 2023. PMID: 36705554
We undertook this study to develop and evaluate a high-affinity APRIL/BAFF antagonist to overcome the clinical limitations of existing B cell inhibitors. ...RESULTS: Povetacicept inhibited APRIL and BAFF more effectively than all evaluated forms of WT TACI-Fc and se …
We undertook this study to develop and evaluate a high-affinity APRIL/BAFF antagonist to overcome the clinical limitations of existin …
Role of the APRIL molecule in solid tumors.
Nowacka KH, Jabłońska E. Nowacka KH, et al. Cytokine Growth Factor Rev. 2021 Oct;61:38-44. doi: 10.1016/j.cytogfr.2021.08.001. Epub 2021 Aug 19. Cytokine Growth Factor Rev. 2021. PMID: 34446365 Free article. Review.
In the present review, we summarize the current knowledge on the effects of APRIL on human cancer development and develop a scheme demonstrating the mechanism of the action of APRIL on solid tumors. ...The correlations observed between APRIL levels and cancer …
In the present review, we summarize the current knowledge on the effects of APRIL on human cancer development and develop a scheme de …
APRIL in B-cell malignancies and autoimmunity.
Kimberley FC, Medema JP, Hahne M. Kimberley FC, et al. Results Probl Cell Differ. 2009;49:161-82. doi: 10.1007/400_2008_19. Results Probl Cell Differ. 2009. PMID: 19142624 Review.
However, we now know that APRIL also plays an important role in the immune system and in lymphocyte biology. In this chapter we outline the physiological role of APRIL in immunity and describe what is known regarding the role of APRIL in B cell malignancies a …
However, we now know that APRIL also plays an important role in the immune system and in lymphocyte biology. In this chapter we outli …
A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence.
Mathur M, Chan TM, Oh KH, Kooienga L, Zhuo M, Pinto CS, Chacko B. Mathur M, et al. J Clin Med. 2023 Nov 4;12(21):6927. doi: 10.3390/jcm12216927. J Clin Med. 2023. PMID: 37959392 Free PMC article. Review.
The preliminary data in ongoing clinical trials indicate that APRIL inhibition can reduce proteinuria and slow the rate of kidney disease progression by acting at an upstream level in IgAN pathogenesis. ...The weight of the preclinical, clinical, and genetic data supportin …
The preliminary data in ongoing clinical trials indicate that APRIL inhibition can reduce proteinuria and slow the rate of kidney dis …
The contribution of a proliferation-inducing ligand (APRIL) and other TNF superfamily members in pathogenesis and progression of IgA nephropathy.
Yeo SC, Barratt J. Yeo SC, et al. Clin Kidney J. 2023 Dec 4;16(Suppl 2):ii9-ii18. doi: 10.1093/ckj/sfad200. eCollection 2023 Dec. Clin Kidney J. 2023. PMID: 38053976 Free PMC article. Review.
Animal and clinical studies support the involvement of APRIL in the pathogenesis and progression of IgAN. An elevated level of APRIL is found in IgAN when compared with controls, which correlates with the level of Gd-IgA1 and associates with more severe disease pres …
Animal and clinical studies support the involvement of APRIL in the pathogenesis and progression of IgAN. An elevated level of APR …
The 14th of April, Past and Present.
Petraglia Kropf S, Trindade Lima N. Petraglia Kropf S, et al. Trop Med Infect Dis. 2020 Jun 18;5(2):100. doi: 10.3390/tropicalmed5020100. Trop Med Infect Dis. 2020. PMID: 32570723 Free PMC article.
In May 2019, the World Health Organization established the "World Chagas Disease Day", to be celebrated on the 14th of April [...]....
In May 2019, the World Health Organization established the "World Chagas Disease Day", to be celebrated on the 14th of April [...]... …
The number 13 of the family: a proliferation inducing ligand.
Baert L, Ahmed MC, Manfroi B, Huard B. Baert L, et al. Curr Opin Immunol. 2021 Aug;71:132-137. doi: 10.1016/j.coi.2021.06.018. Epub 2021 Aug 16. Curr Opin Immunol. 2021. PMID: 34411773 Review.
Based on this function, APRIL has been considered as a valuable target to dampen unwanted antibody production. After reviewing the late data acquired on the physiological function of APRIL in humoral immunity, we will here review the state of the art regarding AP …
Based on this function, APRIL has been considered as a valuable target to dampen unwanted antibody production. After reviewing the la …
199,770 results
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