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Year Number of Results
1997 2
1998 2
1999 8
2000 5
2001 8
2002 11
2003 3
2004 9
2005 10
2006 20
2007 12
2008 13
2009 20
2010 14
2011 16
2012 17
2013 26
2014 26
2015 20
2016 24
2017 29
2018 20
2019 26
2020 30
2021 32
2022 31
2023 40
2024 9

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426 results

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Page 1
Single-Cell Transcriptome Atlas of Murine Endothelial Cells.
Kalucka J, de Rooij LPMH, Goveia J, Rohlenova K, Dumas SJ, Meta E, Conchinha NV, Taverna F, Teuwen LA, Veys K, García-Caballero M, Khan S, Geldhof V, Sokol L, Chen R, Treps L, Borri M, de Zeeuw P, Dubois C, Karakach TK, Falkenberg KD, Parys M, Yin X, Vinckier S, Du Y, Fenton RA, Schoonjans L, Dewerchin M, Eelen G, Thienpont B, Lin L, Bolund L, Li X, Luo Y, Carmeliet P. Kalucka J, et al. Cell. 2020 Feb 20;180(4):764-779.e20. doi: 10.1016/j.cell.2020.01.015. Epub 2020 Feb 13. Cell. 2020. PMID: 32059779 Free article.
We constructed an atlas of >32,000 single-EC transcriptomes from 11 mouse tissues and identified 78 EC subclusters, including Aqp7(+) intestinal capillaries and angiogenic ECs in healthy tissues. ...
We constructed an atlas of >32,000 single-EC transcriptomes from 11 mouse tissues and identified 78 EC subclusters, including Aqp7 …
AQP7 mediates post-menopausal lipogenesis in adipocytes through FSH-induced transcriptional crosstalk with AP-1 sites.
Chen L, Chen H, Liu X, Li J, Gao Q, Shi S, Wang T, Ye X, Lu Y, Zhang D, Sheng J, Jin L, Huang H. Chen L, et al. Reprod Biomed Online. 2020 Dec;41(6):1122-1132. doi: 10.1016/j.rbmo.2020.08.008. Epub 2020 Aug 18. Reprod Biomed Online. 2020. PMID: 33132060
High circulating FSH in post-menopausal women may play an independent role in regulation of the lipogenic effect of AQP7 in adipocytes. This study explored the role of AQP7 in the pathophysiology of post-menopausal lipogenesis mediated by high concentrations of circ …
High circulating FSH in post-menopausal women may play an independent role in regulation of the lipogenic effect of AQP7 in adipocyte …
Cryo-EM structure supports a role of AQP7 as a junction protein.
Huang P, Venskutonytė R, Prasad RB, Ardalani H, de Maré SW, Fan X, Li P, Spégel P, Yan N, Gourdon P, Artner I, Lindkvist-Petersson K. Huang P, et al. Nat Commun. 2023 Feb 3;14(1):600. doi: 10.1038/s41467-023-36272-y. Nat Commun. 2023. PMID: 36737436 Free PMC article.
Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. ...AQP7 is shown to be highly expressed in human pancreatic alpha- and beta- cells suggesting th …
Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolis …
Physiological roles of AQP7 in the kidney: Lessons from AQP7 knockout mice.
Sohara E, Rai T, Sasaki S, Uchida S. Sohara E, et al. Biochim Biophys Acta. 2006 Aug;1758(8):1106-10. doi: 10.1016/j.bbamem.2006.04.002. Epub 2006 Apr 20. Biochim Biophys Acta. 2006. PMID: 16860289 Free article. Review.
In this paper, we review the physiological functions of AQP7 in the kidney. To investigate this, we generated AQP7 knockout mice. ...On the other hand, AQP7 knockout mice showed marked glycerol in their urine (AQP7, 1.7+/-0.34 mg/ml vs. wild-type, 0.00 …
In this paper, we review the physiological functions of AQP7 in the kidney. To investigate this, we generated AQP7 knockout mi …
Aquaglyceroporin AQP7's affinity for its substrate glycerol: Have we reached convergence in the computed values of glycerol-aquaglyceroporin affinity?
Falato M, Chan R, Chen LY. Falato M, et al. RSC Adv. 2022;12(5):3128-3135. doi: 10.1039/d1ra07367b. Epub 2022 Jan 24. RSC Adv. 2022. PMID: 35222995 Free PMC article.
In this, we obtained a lower bound for the AQP7-glycerol affinity (an upper bound for the dissociation constant). Namely, the AQP7-glycerol affinity is stronger than 1087/M (the dissociation constant is less than 0.92 mM). ...
In this, we obtained a lower bound for the AQP7-glycerol affinity (an upper bound for the dissociation constant). Namely, the AQP7 …
LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.
Ishihama S, Yoshida S, Yoshida T, Mori Y, Ouchi N, Eguchi S, Sakaguchi T, Tsuda T, Kato K, Shimizu Y, Ohashi K, Okumura T, Bando YK, Yagyu H, Wettschureck N, Kubota N, Offermanns S, Kadowaki T, Murohara T, Takefuji M. Ishihama S, et al. FASEB J. 2021 Dec;35(12):e22048. doi: 10.1096/fj.202100882R. FASEB J. 2021. PMID: 34807469
Cardiomyocyte-specific LPL deficiency enhanced cardiac dysfunction and apoptosis following MI. Deficiency of aquaporin 7 (AQP7), a glycerol channel in cardiomyocytes, increased the myocardial infarct size and apoptosis in response to ischemia. ...Moreover, cardiomyocyte-sp …
Cardiomyocyte-specific LPL deficiency enhanced cardiac dysfunction and apoptosis following MI. Deficiency of aquaporin 7 (AQP7), a gl …
Metabolic impact of the glycerol channels AQP7 and AQP9 in adipose tissue and liver.
Lebeck J. Lebeck J. J Mol Endocrinol. 2014 Mar 14;52(2):R165-78. doi: 10.1530/JME-13-0268. Print 2014 Apr. J Mol Endocrinol. 2014. PMID: 24463099 Review.
In the liver, glycerol serves as a gluconeogenic precursor and it is used for the esterification of free fatty acid into TGs. Aquaporin 7 (AQP7) in adipose tissue and AQP9 in the liver are transmembrane proteins that belong to the subset of AQPs called aquaglyceroporins. …
In the liver, glycerol serves as a gluconeogenic precursor and it is used for the esterification of free fatty acid into TGs. Aquaporin 7 ( …
Increased AQP7 abundance in skeletal muscle from obese men with type 2 diabetes.
Lebeck J, Søndergaard E, Nielsen S. Lebeck J, et al. Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E367-E373. doi: 10.1152/ajpendo.00468.2017. Epub 2018 May 21. Am J Physiol Endocrinol Metab. 2018. PMID: 29783856 Free article.
Aquaglyceroporin 7 (AQP7) facilitates the transport of glycerol across cell membranes. ...SAT AQP7 abundance was similar in lean and obese T2D men, whereas muscle AQP7 abundance was more than fourfold higher in obese T2D men. ...
Aquaglyceroporin 7 (AQP7) facilitates the transport of glycerol across cell membranes. ...SAT AQP7 abundance was similar in le …
The structural basis for glycerol permeation by human AQP7.
Zhang L, Yao D, Xia Y, Zhou F, Zhang Q, Wang Q, Qin A, Zhao J, Li D, Li Y, Zhou L, Cao Y. Zhang L, et al. Sci Bull (Beijing). 2021 Aug 15;66(15):1550-1558. doi: 10.1016/j.scib.2020.12.006. Epub 2020 Dec 9. Sci Bull (Beijing). 2021. PMID: 36654284
Compared with other human aquaglyceroporins, AQP7 shows a less conserved "NPA" motif in the center cavity and a pair of aromatic residues at Ar/R selectivity filter. ...Glycerol uptake assay on human AQP7 as well as AQP3 and AQP10 demonstrated strong glycerol transp …
Compared with other human aquaglyceroporins, AQP7 shows a less conserved "NPA" motif in the center cavity and a pair of aromatic resi …
Aquaporin Inhibitors.
Wang S, Solenov EI, Yang B. Wang S, et al. Adv Exp Med Biol. 2023;1398:317-330. doi: 10.1007/978-981-19-7415-1_22. Adv Exp Med Biol. 2023. PMID: 36717504
It has been suggested that although they showed inhibition effects on AQP1, AQP3, AQP4, AQP7, or AQP9 in some researches, none of them could be asserted as AQP inhibitors to some extent. ...
It has been suggested that although they showed inhibition effects on AQP1, AQP3, AQP4, AQP7, or AQP9 in some researches, none of the …
426 results