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2001 1
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Page 1
Arhgef5 Binds alpha-Dystrobrevin 1 and Regulates Neuromuscular Junction Integrity.
Bernadzki KM, Daszczuk P, Rojek KO, Pęziński M, Gawor M, Pradhan BS, de Cicco T, Bijata M, Bijata K, Włodarczyk J, Prószyński TJ, Niewiadomski P. Bernadzki KM, et al. Front Mol Neurosci. 2020 Jun 10;13:104. doi: 10.3389/fnmol.2020.00104. eCollection 2020. Front Mol Neurosci. 2020. PMID: 32587503 Free PMC article.
We show here that Arhgef5 localizes to the NMJ and that its genetic depletion in the muscle causes the fragmentation of the synapses in conditional knockout mice. Arhgef5 loss in vivo is associated with a reduction in the levels of active GTP-bound RhoA and Cdc42 GT …
We show here that Arhgef5 localizes to the NMJ and that its genetic depletion in the muscle causes the fragmentation of the synapses …
Ephexin3/ARHGEF5 Together with Cell Migration Signaling Partners within the Tumor Microenvironment Define Prognostic Transcriptional Signatures in Multiple Cancer Types.
Juan-Guadarrama DG, Beltrán-Navarro YM, Reyes-Cruz G, Vázquez-Prado J. Juan-Guadarrama DG, et al. Int J Mol Sci. 2023 Nov 17;24(22):16427. doi: 10.3390/ijms242216427. Int J Mol Sci. 2023. PMID: 38003617 Free PMC article.
Based on the domain architecture of encoded proteins and gene ontology criteria, we selected Ephexin signaling partners with a role in cytoskeletal reorganization and cell migration. We focused on Ephexin3/ARHGEF5, identified as an essential gene in multiple cancer cell ty …
Based on the domain architecture of encoded proteins and gene ontology criteria, we selected Ephexin signaling partners with a role in cytos …
The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition.
Komiya Y, Onodera Y, Kuroiwa M, Nomimura S, Kubo Y, Nam JM, Kajiwara K, Nada S, Oneyama C, Sabe H, Okada M. Komiya Y, et al. Oncogenesis. 2016 Sep 12;5(9):e258. doi: 10.1038/oncsis.2016.59. Oncogenesis. 2016. PMID: 27617642 Free PMC article.
However, ARHGEF5 was not required for tumor growth in epithelial-like human colorectal cancer HCT116 and HT29 cells, whereas the growth of mesenchymal-like SW480 and SW620 cells depended on ARHGEF5. Induction of EMT by tumor necrosis factor-alpha or Slug in HCT116 c …
However, ARHGEF5 was not required for tumor growth in epithelial-like human colorectal cancer HCT116 and HT29 cells, whereas the grow …
The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.
Kuroiwa M, Oneyama C, Nada S, Okada M. Kuroiwa M, et al. J Cell Sci. 2011 May 15;124(Pt 10):1726-38. doi: 10.1242/jcs.080291. Epub 2011 Apr 26. J Cell Sci. 2011. PMID: 21525037
Arhgef5 was tyrosine-phosphorylated by Src and bound to Src to positively regulate its activity. Furthermore, the pleckstrin homology (PH) domain of Arhgef5 was required for podosome formation, and Arhgef5 formed a ternary complex with Src and phosphoinositid …
Arhgef5 was tyrosine-phosphorylated by Src and bound to Src to positively regulate its activity. Furthermore, the pleckstrin homology …
Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. Wang Z, et al. J Biol Chem. 2009 Oct 16;284(42):28599-606. doi: 10.1074/jbc.M109.047282. Epub 2009 Aug 27. J Biol Chem. 2009. PMID: 19713215 Free PMC article.
Arhgef5 can strongly activate RhoA and RhoB and weakly RhoC and RhoG, but not Rac1, RhoQ, RhoD, or RhoV, in transfected human embryonic kidney 293 cells. In addition, Gbetagamma interacts with Arhgef5 and can stimulate Arhgef5-mediated activation of RhoA in a …
Arhgef5 can strongly activate RhoA and RhoB and weakly RhoC and RhoG, but not Rac1, RhoQ, RhoD, or RhoV, in transfected human embryon …
Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer.
Huang O, Wu D, Xie F, Lin L, Wang X, Jiang M, Li Y, Chen W, Shen K, Hu X. Huang O, et al. Amino Acids. 2015 Jun;47(6):1239-46. doi: 10.1007/s00726-015-1950-0. Epub 2015 Mar 6. Amino Acids. 2015. PMID: 25743165
The oncogenic protein ARHGEF5/TIM has long been known to express specifically in human breast cancer and other tumors, which is an important member of Rho guanine nucleotide exchange factors that activate Rho-family GTPases by promoting GTP/GDP exchange. ...
The oncogenic protein ARHGEF5/TIM has long been known to express specifically in human breast cancer and other tumors, which is an im …
Exploring the systematic effect of N-substituted PxxP motifs on peptoid affinity to ARHGEF5/TIM SH3 domain and its relationship with ARHGEF5/TIM activation.
Fu Y, He P, Zhou Y, Huang S, Liang L, Liu S. Fu Y, et al. Proteins. 2019 Nov;87(11):979-991. doi: 10.1002/prot.25760. Epub 2019 Jun 28. Proteins. 2019. PMID: 31197859
The TIM protein is a short isoform of full-length Rho guanine nucleotide exchange factor 5 (ARHGEF5), which acts as a functional regulator of Rho-dependent signaling pathways by activating the Rho family of GTPases. ...
The TIM protein is a short isoform of full-length Rho guanine nucleotide exchange factor 5 (ARHGEF5), which acts as a functional regu …
Expression and molecular characterization of alternative transcripts of the ARHGEF5/TIM oncogene specific for human breast cancer.
Debily MA, Camarca A, Ciullo M, Mayer C, El Marhomy S, Ba I, Jalil A, Anzisi A, Guardiola J, Piatier-Tonneau D. Debily MA, et al. Hum Mol Genet. 2004 Feb 1;13(3):323-34. doi: 10.1093/hmg/ddh024. Epub 2003 Dec 8. Hum Mol Genet. 2004. PMID: 14662653
The ARHGEF5/TIM oncogene belongs to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. ...We report here the identification of five novel ARHGEF5/TIM alternative transcripts specifically expressed in breast tumors. ...
The ARHGEF5/TIM oncogene belongs to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. ...We report here t …
The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease.
Zhu S, Xiang C, Charlesworth O, Bennett S, Zhang S, Zhou M, Kujan O, Xu J. Zhu S, et al. Front Physiol. 2022 Sep 2;13:1003931. doi: 10.3389/fphys.2022.1003931. eCollection 2022. Front Physiol. 2022. PMID: 36117697 Free PMC article. Review.
ODAM, as a secreted protein which is accumulated at the interface between basal lamina and enamel, mediates the adhesion of the JE to the tooth surface; and is involved with extracellular signalling of WNT and ARHGEF5-RhoA, as well as intracellular signalling of BMP-2-BMPR …
ODAM, as a secreted protein which is accumulated at the interface between basal lamina and enamel, mediates the adhesion of the JE to the to …
The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers.
He P, Tan DL, Liu HX, Lv FL, Wu W. He P, et al. Biochimie. 2015 Apr;111:10-8. doi: 10.1016/j.biochi.2015.01.011. Epub 2015 Jan 31. Biochimie. 2015. PMID: 25645980
The short isoform of Rho guanine nucleotide exchange factor ARHGEF5 is known as TIM, which plays diverse roles in, for example, tumorigenesis, neuronal development and Src-induced podosome formation through the activation of its substrates, the Rho family of GTPases. ...
The short isoform of Rho guanine nucleotide exchange factor ARHGEF5 is known as TIM, which plays diverse roles in, for example, tumor …
38 results