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64 results

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Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence.
Mamula D, Korthals M, Hradsky J, Gottfried A, Fischer KD, Tedford K. Mamula D, et al. J Leukoc Biol. 2021 Nov;110(5):839-852. doi: 10.1002/JLB.1A1219-719R. Epub 2021 Feb 2. J Leukoc Biol. 2021. PMID: 33527537
In Arhgef6(-/-) T cells, expression of Arhgef7 (beta-PIX; betaPIX; Cool-1), a homolog of Arhgef6, was increased and correlated with defective activation and localization of Rac1 and CDC42 GTPases, respectively. ...Together, these findings reveal that Arhgef6 …
In Arhgef6(-/-) T cells, expression of Arhgef7 (beta-PIX; betaPIX; Cool-1), a homolog of Arhgef6, was increased and correlated …
Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs.
Klämbt V, Buerger F, Wang C, Naert T, Richter K, Nauth T, Weiss AC, Sieckmann T, Lai E, Connaughton DM, Seltzsam S, Mann N, Majmundar AJ, Wu CW, Onuchic-Whitford AC, Shril S, Schneider S, Schierbaum L, Dai R, Bekheirnia MR, Joosten M, Shlomovitz O, Vivante A, Banne E, Mane S, Lifton RP, Kirschner KM, Kispert A, Rosenberger G, Fischer KD, Lienkamp SS, Zegers MMP, Hildebrandt F. Klämbt V, et al. J Am Soc Nephrol. 2023 Feb 1;34(2):273-290. doi: 10.1681/ASN.2022010050. Epub 2023 Nov 22. J Am Soc Nephrol. 2023. PMID: 36414417 Free PMC article.
We also assessed the effects in vitro of wild-type and mutant ARHGEF6 proteins, and the effects of Arhgef6 deficiency in mouse and frog models. ...Arhgef6 deficiency in mouse and frog models recapitulated features of human CAKUT. ...
We also assessed the effects in vitro of wild-type and mutant ARHGEF6 proteins, and the effects of Arhgef6 deficiency in mouse …
Combined ARHGEF6 and Tumor Mutational Burden may serve as a potential biomarker for immunotherapy of lung adenocarcinoma.
Tong L, Wang S, Yang J, Zhang Q, Gu X, Mo T, Luo Y, Zhang C, Zhang J, Liu Y. Tong L, et al. Heliyon. 2023 Aug 6;9(8):e18501. doi: 10.1016/j.heliyon.2023.e18501. eCollection 2023 Aug. Heliyon. 2023. PMID: 37600416 Free PMC article.
ARHGEF6, a member of the Dbl-related guanylate exchanger (GEF) family, is highly expressed in gastric cancer and glioma. ...Meanwhile, ARHGEF6 was found to be negatively correlated with TMB. In conclusion, the results of this study suggest that ARHGEF6 is a p …
ARHGEF6, a member of the Dbl-related guanylate exchanger (GEF) family, is highly expressed in gastric cancer and glioma. ...Meanwhile …
Comprehensive analysis identifies ARHGEF6 as a potential prognostic and immunological biomarker in lung adenocarcinoma.
Wang N, Li Y, Zhou X, Wang X, Yang G. Wang N, et al. Comput Biol Med. 2023 Feb;153:106448. doi: 10.1016/j.compbiomed.2022.106448. Epub 2022 Dec 20. Comput Biol Med. 2023. PMID: 36586227
Moreover, ARHGEF6 presented high diagnostic value in LUAD patients (AUC = 0.949), and the patients with low ARHGEF6 expression had more somatic mutations and poor T stage, N stage, clinical prognosis. ...The overexpression of ARHGEF6 remarkably attenuated the …
Moreover, ARHGEF6 presented high diagnostic value in LUAD patients (AUC = 0.949), and the patients with low ARHGEF6 expression …
The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma.
Zheng T, Zhou H, Zheng Z, Guo Y, Liu J, Zhang J, Li S. Zheng T, et al. Comput Biol Med. 2023 May;158:106894. doi: 10.1016/j.compbiomed.2023.106894. Epub 2023 Apr 10. Comput Biol Med. 2023. PMID: 37058762 Free article.
BACKGROUND: Emerging evidences suggest that ARHGEF6 is involved in cancers but the exact significance and underlying mechanism are unclear. ...Mast cells, T cells and NK cells were the first three cells with the highest expression of ARHGEF6 in LUAD tissues. Overexp …
BACKGROUND: Emerging evidences suggest that ARHGEF6 is involved in cancers but the exact significance and underlying mechanism are un …
Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice.
Zhu C, Cheng C, Wang Y, Muhammad W, Liu S, Zhu W, Shao B, Zhang Z, Yan X, He Q, Xu Z, Yu C, Qian X, Lu L, Zhang S, Zhang Y, Xiong W, Gao X, Xu Z, Chai R. Zhu C, et al. Front Mol Neurosci. 2018 Oct 2;11:362. doi: 10.3389/fnmol.2018.00362. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30333726 Free PMC article.
Arhgef6 is the X-linked intellectual disability gene also known as XLID46, and clinical features of patients carrying Arhgef6 mutations include intellectual disability and, in some cases, sensorineural hearing loss. ...At the molecular level, the levels of active CD …
Arhgef6 is the X-linked intellectual disability gene also known as XLID46, and clinical features of patients carrying Arhgef6 …
Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.
Rosenberger G, Jantke I, Gal A, Kutsche K. Rosenberger G, et al. Hum Mol Genet. 2003 Jan 15;12(2):155-67. doi: 10.1093/hmg/ddg019. Hum Mol Genet. 2003. PMID: 12499396
In addition, interaction of ARHGEF6 to ARHGEF7 (betaPIX or Cool-1), a close homolog of ARHGEF6, was confirmed. ...Binding between ARHGEF6 and ARHGEF7 was not affected by ARHGEF6 deltaaa56-83 but did not occur with ARHGEF6 deltaaa396-776. ...
In addition, interaction of ARHGEF6 to ARHGEF7 (betaPIX or Cool-1), a close homolog of ARHGEF6, was confirmed. ...Binding betw …
Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study.
Li K, Wang H, Yang C, Li C, Xue B, Zhou J. Li K, et al. PLoS One. 2023 Apr 7;18(4):e0283934. doi: 10.1371/journal.pone.0283934. eCollection 2023. PLoS One. 2023. PMID: 37027440 Free PMC article.
Our research showed that the expression of ARHGEF6 was mainly higher in AML cell lines, meanwhile, was highest in the samples from patients with AML compared to other cancer types. ...Therefore, ARHGEF6 can become a prognostic marker in AML; ARHGEF6low patients can …
Our research showed that the expression of ARHGEF6 was mainly higher in AML cell lines, meanwhile, was highest in the samples from pa …
Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.
Nagy Z, Wynne K, von Kriegsheim A, Gambaryan S, Smolenski A. Nagy Z, et al. J Biol Chem. 2015 Dec 11;290(50):29974-83. doi: 10.1074/jbc.M115.678003. Epub 2015 Oct 27. J Biol Chem. 2015. PMID: 26507661 Free PMC article.
Reduced CIP4 binding results in enhanced inhibition of cell migration by ARHGAP17. Furthermore, we show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protei …
Reduced CIP4 binding results in enhanced inhibition of cell migration by ARHGAP17. Furthermore, we show that ARHGEF6 is constitutivel …
The mouse Arhgef6 gene: cDNA sequence, expression analysis, and chromosome assignment.
Kutsche K, Gal A. Kutsche K, et al. Cytogenet Cell Genet. 2001;95(3-4):196-201. doi: 10.1159/000059346. Cytogenet Cell Genet. 2001. PMID: 12063400
Here we report the identification and characterization of the orthologous mouse gene, Arhgef6. The gene transcript of approximately 4.4 kb is present in various mouse tissues indicating ubiquitous expression as found for human ARHGEF6. ...A genomic cosmid clone cont …
Here we report the identification and characterization of the orthologous mouse gene, Arhgef6. The gene transcript of approximately 4 …
64 results