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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 3
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2005 9
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2009 5
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2011 4
2012 8
2013 5
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2015 5
2016 5
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105 results

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Page 1
ARL6IP5 Ameliorates alpha-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12.
Siddique I, Kamble K, Gupta S, Solanki K, Bhola S, Ahsan N, Gupta S. Siddique I, et al. Int J Mol Sci. 2023 Jun 22;24(13):10499. doi: 10.3390/ijms241310499. Int J Mol Sci. 2023. PMID: 37445677 Free PMC article.
To address this, in our present study, we identified a novel regulator (ARL6IP5) of neuronal autophagy and showed that the level of ARL6IP5 decreases in the brain with age and in Parkinson's disease in mice and humans. ...Interestingly, detailed mechanistic studies …
To address this, in our present study, we identified a novel regulator (ARL6IP5) of neuronal autophagy and showed that the level of …
ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma.
Kim JY, Bahar E, Lee JY, Chang S, Kim SH, Park EY, Do SI, Yoon H, Kim HS. Kim JY, et al. Cell Death Dis. 2022 Mar 15;13(3):239. doi: 10.1038/s41419-022-04568-4. Cell Death Dis. 2022. PMID: 35293383 Free PMC article.

Notably, ARL6IP5-OE reduced cisplatin-resistance of both OC and CisR OC cells, while ARL6IP5-KD increased cisplatin-resistance (p < 0.05). ARL6IP5-OE suppressed the expressions of DNA repair proteins and increased those of pro-apoptotic proteins; the oppos

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Notably, ARL6IP5-OE reduced cisplatin-resistance of both OC and CisR OC cells, while ARL6IP5-KD increased cisplatin-resistance …
Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.
Wu Y, Wang M, Peng Y, Ding Y, Deng L, Fu Q. Wu Y, et al. Biochem Biophys Res Commun. 2015 Sep 4;464(4):1275-1281. doi: 10.1016/j.bbrc.2015.07.119. Epub 2015 Jul 26. Biochem Biophys Res Commun. 2015. PMID: 26220341
Moreover, Arl6ip5 bound with RANKL and disturbed the RANKL-OPG complex in UAMS-32 cells. Finally, 1 to 36 amino acid deletion on the NH2 lumen terminus of Arl6ip5 impaired the interaction between Arl6ip5 and RANKL, restored the level of soluble RANKL and the …
Moreover, Arl6ip5 bound with RANKL and disturbed the RANKL-OPG complex in UAMS-32 cells. Finally, 1 to 36 amino acid deletion on the …
Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.
Wu Y, Yang M, Fan J, Peng Y, Deng L, Ding Y, Yang R, Zhou J, Miao D, Fu Q. Wu Y, et al. Cell Death Dis. 2014 Oct 16;5(10):e1464. doi: 10.1038/cddis.2014.427. Cell Death Dis. 2014. PMID: 25321471 Free PMC article.
However, its expression pattern and functional role in bone are unknown. Here we demonstrate that Arl6ip5 knock-out mice (Arl6ip5 (delta2/delta2)) show marked decrease of bone mineral density, trabecular bone volume and trabecular thickness. ...In addition, ER stres …
However, its expression pattern and functional role in bone are unknown. Here we demonstrate that Arl6ip5 knock-out mice (Arl6ip5 …
Single Nucleus Transcriptome Data from Alzheimer's Disease Mouse Models Yield New Insight into Pathophysiology.
Weller AE, Ferraro TN, Doyle GA, Reiner BC, Crist RC, Berrettini WH. Weller AE, et al. J Alzheimers Dis. 2022;90(3):1233-1247. doi: 10.3233/JAD-220391. J Alzheimers Dis. 2022. PMID: 36213995
RESULTS: We identified several DEGs in both neuronal and glial cell subtypes in comparisons of wild type (WT) versus 5XFAD and WT versus T2KO mice, including Ttr, Fth1, Pcsk1n, Malat1, Rpl37, Rtn1, Sepw1, Uba52, Mbp, Arl6ip5, Gm26917, Vwa1, and Pgrmc1. We also observed DTU …
RESULTS: We identified several DEGs in both neuronal and glial cell subtypes in comparisons of wild type (WT) versus 5XFAD and WT versus T2K …
Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery.
Ding K, Liu X, Wang L, Zou L, Jiang X, Li A, Zhou J. Ding K, et al. Cancers (Basel). 2022 Sep 24;14(19):4655. doi: 10.3390/cancers14194655. Cancers (Basel). 2022. PMID: 36230577 Free PMC article. Review.
JWA, also known as ADP ribosylation factor-like GTPase 6 interacting protein 5 (ARL6IP5, GenBank: AF070523, 1998), is a microtubule-associated protein and an environmental response gene. ...
JWA, also known as ADP ribosylation factor-like GTPase 6 interacting protein 5 (ARL6IP5, GenBank: AF070523, 1998), is a microtubule-a …
Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson's Disease Animal Models from a Molecular Signaling Perspective.
Udovin L, Quarracino C, Herrera MI, Capani F, Otero-Losada M, Perez-Lloret S. Udovin L, et al. Neural Plast. 2020 Feb 7;2020:1859431. doi: 10.1155/2020/1859431. eCollection 2020. Neural Plast. 2020. PMID: 32089670 Free PMC article. Review.
Another major pathway involves IkappaB kinase (IKK) downregulation by ARL6ip5 (ADP-ribosylation-like factor 6 interacting protein 5, encoded by the cell differentiation-associated, JWA, gene). Typically, IKK releases the proinflammatory NF-kappaB (nuclear factor kappa-ligh …
Another major pathway involves IkappaB kinase (IKK) downregulation by ARL6ip5 (ADP-ribosylation-like factor 6 interacting protein 5, …
Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis.
Wu Y, Bai Y, McEwan DG, Bentley L, Aravani D, Cox RD. Wu Y, et al. Biol Open. 2021 Dec 15;10(12):bio058420. doi: 10.1242/bio.058420. Epub 2021 Dec 13. Biol Open. 2021. PMID: 34779483 Free PMC article.
Finally, co-immunoprecipitation and mass spectrometry identified potential interacting partners of ARL15, including the ER-localised protein ARL6IP5. Together, these results suggest a palmitoylation dependent trafficking-related role of ARL15 as a regulator of adipocyte di …
Finally, co-immunoprecipitation and mass spectrometry identified potential interacting partners of ARL15, including the ER-localised protein …
Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencing.
Zhao J, Xu L, Wei K, Jiang P, Chang C, Xu L, Shi Y, Zheng Y, Shan Y, Zheng Y, Shen Y, Liu J, Guo S, Wang R, He D. Zhao J, et al. Int Immunopharmacol. 2024 Apr 20;131:111860. doi: 10.1016/j.intimp.2024.111860. Epub 2024 Mar 19. Int Immunopharmacol. 2024. PMID: 38508093
RESULTS: The study identified 16 important CG sites, including tumor necrosis factort receptor associated factor 5 (TRAF5) (chr1:211500151), mothers against decapentaplegic homolog 3 (SMAD3) (chr15:67357339), tumor endothelial marker 1 (CD248) (chr11:66083766), lysosomal traffick …
RESULTS: The study identified 16 important CG sites, including tumor necrosis factort receptor associated factor 5 (TRAF5) (chr1:211500151), …
105 results