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N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Varland S, Silva RD, Kjosås I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, Lee JJ, Nedyalkova L, Ušaj M, Whitworth AJ, Andrews BJ, Moffat J, Myers CL, Gevaert K, Boone C, Martinho RG, Arnesen T. Varland S, et al. Among authors: arnesen t. Nat Commun. 2023 Oct 27;14(1):6774. doi: 10.1038/s41467-023-42342-y. Nat Commun. 2023. PMID: 37891180 Free PMC article.
Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase.
Van Damme P, Evjenth R, Foyn H, Demeyer K, De Bock PJ, Lillehaug JR, Vandekerckhove J, Arnesen T, Gevaert K. Van Damme P, et al. Among authors: arnesen t. Mol Cell Proteomics. 2011 May;10(5):M110.004580. doi: 10.1074/mcp.M110.004580. Epub 2011 Mar 7. Mol Cell Proteomics. 2011. PMID: 21383206 Free PMC article.
Protein alpha-N-acetylation studied by N-terminomics.
Van Damme P, Arnesen T, Gevaert K. Van Damme P, et al. Among authors: arnesen t. FEBS J. 2011 Oct;278(20):3822-34. doi: 10.1111/j.1742-4658.2011.08230.x. Epub 2011 Aug 2. FEBS J. 2011. PMID: 21736701 Free article. Review.
Protein N-terminal acetyltransferases: when the start matters.
Starheim KK, Gevaert K, Arnesen T. Starheim KK, et al. Among authors: arnesen t. Trends Biochem Sci. 2012 Apr;37(4):152-61. doi: 10.1016/j.tibs.2012.02.003. Epub 2012 Mar 7. Trends Biochem Sci. 2012. PMID: 22405572 Review.
155 results