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1997 1
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Zhu H, Klement JD, Lu C, Redd PS, Yang D, Smith AD, Poschel DB, Zou J, Liu D, Wang PG, Ostrov D, Coant N, Hannun YA, Colby AH, Grinstaff MW, Liu K. Zhu H, et al. J Immunol. 2021 Mar 15;206(6):1395-1404. doi: 10.4049/jimmunol.2000500. Epub 2021 Feb 5. J Immunol. 2021. PMID: 33547170 Free PMC article.
To target ASAH2, we performed molecular docking based on human ASAH2 protein structure. ...NC06 inhibits ceramidase activity with an IC(50) of 10.16-25.91 muM for human ASAH2 and 18.6-30.2 muM for mouse Asah2 proteins. NC06 induces MDSC death in a dose …
To target ASAH2, we performed molecular docking based on human ASAH2 protein structure. ...NC06 inhibits ceramidase activity w …
Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models.
Su L, Chen Y, Huang C, Wu S, Wang X, Zhao X, Xu Q, Sun R, Kong X, Jiang X, Qiu X, Huang X, Wang M, Wong PP. Su L, et al. Sci Transl Med. 2023 Jan 11;15(678):eabl7895. doi: 10.1126/scitranslmed.abl7895. Epub 2023 Jan 11. Sci Transl Med. 2023. PMID: 36630483
Here, we demonstrate that beta5-integrin represses chemotherapy-induced canonical pyroptosis to confer cancer chemoresistance through ASAH2-driven sphingolipid metabolic reprogramming. Clinically, high beta5-integrin expression associates with poor patient prognosis and ch …
Here, we demonstrate that beta5-integrin represses chemotherapy-induced canonical pyroptosis to confer cancer chemoresistance through ASA …
Role of Ceramidases in Sphingolipid Metabolism and Human Diseases.
Parveen F, Bender D, Law SH, Mishra VK, Chen CC, Ke LY. Parveen F, et al. Cells. 2019 Dec 4;8(12):1573. doi: 10.3390/cells8121573. Cells. 2019. PMID: 31817238 Free PMC article. Review.
In humans, five different ceramidases are known-acid ceramidase, neutral ceramidase, and alkaline ceramidase 1, 2, and 3-which are encoded by five different genes (ASAH1, ASAH2, ACER1, ACER2, and ACER3, respectively). Notably, the neutral ceramidase N-acylsphingosine amido …
In humans, five different ceramidases are known-acid ceramidase, neutral ceramidase, and alkaline ceramidase 1, 2, and 3-which are encoded b …
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.
Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL. Kono M, et al. J Biol Chem. 2006 Mar 17;281(11):7324-31. doi: 10.1074/jbc.M508382200. Epub 2005 Dec 27. J Biol Chem. 2006. PMID: 16380386 Free article.
To explore the physiological functions of a neutral ceramidase with diverse cellular locations, we disrupted the Asah2 gene in mice. Asah2 null mice have a normal life span and do not show obvious abnormalities or major alterations in total ceramide levels in tissue …
To explore the physiological functions of a neutral ceramidase with diverse cellular locations, we disrupted the Asah2 gene in mice. …
Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulating alpha1,2-Fucosylation of Asah2 and Npc1.
Duan C, Wang Z, Wu J, Tan C, Fang F, Qian W, Han C, Hou X. Duan C, et al. Research (Wash D C). 2024 Mar 27;7:0343. doi: 10.34133/research.0343. eCollection 2024. Research (Wash D C). 2024. PMID: 38550777 Free PMC article.
Finally, Fut2 was demonstrated to regulate mitochondrial functions mainly by regulating the alpha1,2-fucosylation of N-acyl sphingosine amidohydrolase 2 (Asah2) and Niemann-Pick type C intracellular cholesterol transporter 1 (Npc1). ...
Finally, Fut2 was demonstrated to regulate mitochondrial functions mainly by regulating the alpha1,2-fucosylation of N-acyl sphingosine amid …
New candidate blood biomarkers potentially associated with white matter hyperintensities progression.
Jiménez-Balado J, Pizarro J, Riba-Llena I, Penalba A, Faura J, Palà E, Montaner J, Hernández-Guillamon M, Delgado P. Jiménez-Balado J, et al. Sci Rep. 2021 Jul 12;11(1):14324. doi: 10.1038/s41598-021-93498-w. Sci Rep. 2021. PMID: 34253757 Free PMC article.
The selected protein candidates for the replication were MMP9 (matrix metalloproteinase-9), which was higher in cases, MET (hepatocyte growth factor receptor) and ASAH2 (neutral ceramidase), which were both lower in cases of WMH progression. ...In contrast, patients with W …
The selected protein candidates for the replication were MMP9 (matrix metalloproteinase-9), which was higher in cases, MET (hepatocyte growt …
Acute physiological effects following Bacillus subtilis DE111 oral ingestion - a randomised, double blinded, placebo-controlled study.
Colom J, Freitas D, Simon A, Khokhlova E, Mazhar S, Buckley M, Phipps C, Deaton J, Brodkorb A, Rea K. Colom J, et al. Benef Microbes. 2023 Mar 14;14(1):31-44. doi: 10.3920/BM2022.0081. Epub 2023 Feb 15. Benef Microbes. 2023. PMID: 36790091 Clinical Trial.
The combination of B. subtilis DE111 and the diet administered during the study increased the expression of the proteins phosphodiesterase ENPP7, ceramidase ASAH2 and the adipokine Zn-alpha-2-glycoprotein that are involved in fatty acid and lipid metabolism. ...
The combination of B. subtilis DE111 and the diet administered during the study increased the expression of the proteins phosphodiesterase E …
Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population.
Price TR, Emfinger CH, Schueler KL, King S, Nicholson R, Beck T, Yandell BS, Summers SA, Holland WL, Krauss RM, Keller MP, Attie AD. Price TR, et al. J Lipid Res. 2023 Dec;64(12):100471. doi: 10.1016/j.jlr.2023.100471. Epub 2023 Nov 7. J Lipid Res. 2023. PMID: 37944753 Free PMC article.
This approach enabled us to nominate the gene encoding the neutral ceramidase, Asah2, as a novel candidate driver at a QTL on chromosome 19 for large HDL particles (HDL-2b). To experimentally validate Asah2, we surveyed lipoproteins in Asah2(-/-) mice. Compar …
This approach enabled us to nominate the gene encoding the neutral ceramidase, Asah2, as a novel candidate driver at a QTL on chromos …
Colon Cancer and Perturbations of the Sphingolipid Metabolism.
Machala M, Procházková J, Hofmanová J, Králiková L, Slavík J, Tylichová Z, Ovesná P, Kozubík A, Vondráček J. Machala M, et al. Int J Mol Sci. 2019 Nov 30;20(23):6051. doi: 10.3390/ijms20236051. Int J Mol Sci. 2019. PMID: 31801289 Free PMC article. Review.
72 results