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Page 1
PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
Chou MC, Wang YH, Chen FY, Kung CY, Wu KP, Kuo JC, Chan SJ, Cheng ML, Lin CY, Chou YC, Ho MC, Firestine S, Huang JR, Chen RH. Chou MC, et al. Mol Cell. 2023 Nov 16;83(22):4123-4140.e12. doi: 10.1016/j.molcel.2023.09.028. Epub 2023 Oct 16. Mol Cell. 2023. PMID: 37848033
Here, we show that K6-polyubiquitination of the DNPS enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (PAICS) by cullin-5/ankyrin repeat and SOCS box containing 11 (Cul5/ASB11)-based ubiquitin ligase plays a driv …
Here, we show that K6-polyubiquitination of the DNPS enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccino …
asb11 is a regulator of embryonic and adult regenerative myogenesis.
Tee JM, Sartori da Silva MA, Rygiel AM, Muncan V, Bink R, van den Brink GR, van Tijn P, Zivkovic D, Kodach LL, Guardavaccaro D, Diks SH, Peppelenbosch MP. Tee JM, et al. Stem Cells Dev. 2012 Nov 20;21(17):3091-103. doi: 10.1089/scd.2012.0123. Epub 2012 Jun 7. Stem Cells Dev. 2012. PMID: 22512762 Free PMC article.
Thus, the expression of d-asb11 is necessary for muscle progenitor expansion, whereas its downregulation marks the onset of terminal differentiation. Hence, we provide evidence that d-asb11 is a principal regulator of embryonic as well as adult regenerative myogenes …
Thus, the expression of d-asb11 is necessary for muscle progenitor expansion, whereas its downregulation marks the onset of terminal …
The UBE2F-CRL5(ASB11)-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells.
Chang Y, Chen Q, Li H, Xu J, Tan M, Xiong X, Sun Y. Chang Y, et al. Dev Cell. 2024 Apr 2:S1534-5807(24)00183-7. doi: 10.1016/j.devcel.2024.03.018. Online ahead of print. Dev Cell. 2024. PMID: 38574733 Free article.
Mechanistically, Ube2f deletion inactivates the Mapk-c-Myc signals via blocking ubiquitylation of Diras2, a substrate of CRL5(Asb11) E3 ligase. Biologically, DIRAS2 suppresses growth and survival of human pancreatic cancer cells harboring mutant KRAS, and Diras2 deletion l …
Mechanistically, Ube2f deletion inactivates the Mapk-c-Myc signals via blocking ubiquitylation of Diras2, a substrate of CRL5(Asb11) …
LncRNA HAGLR May Aggravate Melanoma Malignancy Via miR-4644/ASB11 Pathway.
Luo L, Zhang W, Li Z. Luo L, et al. Mol Biotechnol. 2023 Oct;65(10):1619-1631. doi: 10.1007/s12033-023-00672-8. Epub 2023 Feb 3. Mol Biotechnol. 2023. PMID: 36735150
Mechanistically, HAGLR sponges miR-4644, increasing the levels of ASB11 and further aggravating melanoma. It latter negatively targets ASB11 in melanoma cells. Hence, the HAGLR-miR-4644-ASB11 axis may be a promising target for melanoma treatment....
Mechanistically, HAGLR sponges miR-4644, increasing the levels of ASB11 and further aggravating melanoma. It latter negatively target …
d-Asb11 is an essential mediator of canonical Delta-Notch signalling.
Diks SH, Sartori da Silva MA, Hillebrands JL, Bink RJ, Versteeg HH, van Rooijen C, Brouwers A, Chitnis AB, Peppelenbosch MP, Zivkovic D. Diks SH, et al. Nat Cell Biol. 2008 Oct;10(10):1190-8. doi: 10.1038/ncb1779. Epub 2008 Sep 7. Nat Cell Biol. 2008. PMID: 18776899
This process of lateral inhibition results in selection of either Delta-signalling cells or Notch-signalling cells. Here we show that d-Asb11 is an important mediator of this lateral inhibition. In zebrafish embryos, morpholino oligonucleotide (MO)-mediated knockdown of d- …
This process of lateral inhibition results in selection of either Delta-signalling cells or Notch-signalling cells. Here we show that d-A …
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY, Hung MC, Chen RH. Chen FY, et al. J Cell Biol. 2019 Sep 2;218(9):3002-3018. doi: 10.1083/jcb.201901156. Epub 2019 Aug 6. J Cell Biol. 2019. PMID: 31387940 Free PMC article.
However, the mechanism of this regulation and its physiological functions remain elusive. Here, we identify Cul5-ASB11 as the E3 ligase targeting BIK for ubiquitination and degradation. ...Conversely, genotoxic agents down-regulate this IRE1alpha-XBP1s-ASB11 axis an …
However, the mechanism of this regulation and its physiological functions remain elusive. Here, we identify Cul5-ASB11 as the E3 liga …
The novel gene asb11: a regulator of the size of the neural progenitor compartment.
Diks SH, Bink RJ, van de Water S, Joore J, van Rooijen C, Verbeek FJ, den Hertog J, Peppelenbosch MP, Zivkovic D. Diks SH, et al. J Cell Biol. 2006 Aug 14;174(4):581-92. doi: 10.1083/jcb.200601081. Epub 2006 Aug 7. J Cell Biol. 2006. PMID: 16893969 Free PMC article.
Knockdown of the d-Asb11 protein altered the expression of neural precursor genes sox2 and sox3 and resulted in an initial relative increase in proneural cell numbers. ...Overexpression of d-Asb11 in both a pluripotent and a neural-committed progenitor cell line res …
Knockdown of the d-Asb11 protein altered the expression of neural precursor genes sox2 and sox3 and resulted in an initial relative i …
Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action.
Liu P, Verhaar AP, Peppelenbosch MP. Liu P, et al. Trends Biochem Sci. 2019 Jan;44(1):64-74. doi: 10.1016/j.tibs.2018.10.003. Epub 2018 Nov 13. Trends Biochem Sci. 2019. PMID: 30446376 Review.
The subfamily of six-ankyrin repeat domain-containing Asb proteins (Asb5, Asb9, Asb11, and Asb13) is of specific interest because they display unusual strong evolutionary conservation (e.g., urochordate and human ASB11 are >49% similar at the amino acid level) an …
The subfamily of six-ankyrin repeat domain-containing Asb proteins (Asb5, Asb9, Asb11, and Asb13) is of specific interest because the …
The prevention of schizophrenia.
Brown AS, McGrath JJ. Brown AS, et al. Schizophr Bull. 2011 Mar;37(2):257-61. doi: 10.1093/schbul/sbq122. Epub 2010 Oct 27. Schizophr Bull. 2011. PMID: 20980445 Free PMC article. Review. No abstract available.
Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.
Sartori da Silva MA, Tee JM, Paridaen J, Brouwers A, Runtuwene V, Zivkovic D, Diks SH, Guardavaccaro D, Peppelenbosch MP. Sartori da Silva MA, et al. PLoS One. 2010 Nov 19;5(11):e14023. doi: 10.1371/journal.pone.0014023. PLoS One. 2010. PMID: 21124961 Free PMC article.
To explore the biological functions of the cullin box domain of ankyrin repeat and SOCS-box containing protein 11 (d-Asb11), a key mediator of canonical Delta-Notch signaling, we isolated a zebrafish mutant lacking the Cul5 box (Asb11(Cul)). ...Accordingly, proper c …
To explore the biological functions of the cullin box domain of ankyrin repeat and SOCS-box containing protein 11 (d-Asb11), a key me …
49 results