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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim JS, Waldman T, Lord CJ, Ashworth A. Mendes-Pereira AM, et al. Among authors: ashworth a. EMBO Mol Med. 2009 Sep;1(6-7):315-22. doi: 10.1002/emmm.200900041. EMBO Mol Med. 2009. PMID: 20049735 Free PMC article.
Resistance to therapy caused by intragenic deletion in BRCA2.
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. Edwards SL, et al. Among authors: ashworth a. Nature. 2008 Feb 28;451(7182):1111-5. doi: 10.1038/nature06548. Epub 2008 Feb 10. Nature. 2008. PMID: 18264088
DNA repair deficiency as a therapeutic target in cancer.
Martin SA, Lord CJ, Ashworth A. Martin SA, et al. Among authors: ashworth a. Curr Opin Genet Dev. 2008 Feb;18(1):80-6. doi: 10.1016/j.gde.2008.01.016. Epub 2008 Mar 14. Curr Opin Genet Dev. 2008. PMID: 18343102 Review.
Targeted therapy for cancer using PARP inhibitors.
Lord CJ, Ashworth A. Lord CJ, et al. Among authors: ashworth a. Curr Opin Pharmacol. 2008 Aug;8(4):363-9. doi: 10.1016/j.coph.2008.06.016. Curr Opin Pharmacol. 2008. PMID: 18644251 Review.
Synthetic lethal approaches to breast cancer therapy.
Rehman FL, Lord CJ, Ashworth A. Rehman FL, et al. Among authors: ashworth a. Nat Rev Clin Oncol. 2010 Dec;7(12):718-24. doi: 10.1038/nrclinonc.2010.172. Epub 2010 Oct 19. Nat Rev Clin Oncol. 2010. PMID: 20956981 Review.
822 results