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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1999 1
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2001 9
2002 10
2003 7
2004 12
2005 11
2006 14
2007 20
2008 29
2009 27
2010 35
2011 31
2012 24
2013 37
2014 45
2015 45
2016 37
2017 42
2018 40
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2020 45
2021 44
2022 25
2023 14
2024 9

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564 results

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Page 1
ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.
Wang YM, Tang H, Tang YJ, Liu J, Yin YF, Tang YL, Feng YG, Gu HF. Wang YM, et al. J Adv Res. 2023 Nov 4:S2090-1232(23)00327-2. doi: 10.1016/j.jare.2023.11.004. Online ahead of print. J Adv Res. 2023. PMID: 37931656 Free article.
Finally, we validated the role of ASIC1/RIP1 signaling in lipophagy in vivo (human and mice) and in vitro (RAW264.7 and HTP-1 cells). ...Targeting ASIC1 represents a promising therapeutic avenue for the treatment of atherosclerosis....
Finally, we validated the role of ASIC1/RIP1 signaling in lipophagy in vivo (human and mice) and in vitro (RAW264.7 and HTP-1 cells). …
ASIC1 inhibition impairs the proliferation and migration of pancreatic stellate cells induced by pancreatic cancer cells.
Zhu L, Yin J, Zheng F, Ji L, Yu Y, Liu H. Zhu L, et al. Neoplasma. 2021 Jan;68(1):174-179. doi: 10.4149/neo_2020_200803N811. Epub 2020 Oct 22. Neoplasma. 2021. PMID: 33516168
However, whether ASIC1 is involved in pancreatic cancer cells-induced biological behavior re-educating of PSCs is unclear. ...The results showed that pancreatic cancer cells induced ASIC1 overexpression, and the enhanced proliferation and migration of PSCs was weake …
However, whether ASIC1 is involved in pancreatic cancer cells-induced biological behavior re-educating of PSCs is unclear. ...The res …
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors.
Ackermann K, Wallner S, Brochhausen C, Schreml S. Ackermann K, et al. Int J Mol Sci. 2021 Jun 2;22(11):6024. doi: 10.3390/ijms22116024. Int J Mol Sci. 2021. PMID: 34199609 Free PMC article.
Some NCN show a decreasing ASIC1/2 expression in deeper dermal tumor tissue, while MM seem to not lose ASIC1/2 in deeper dermal portions. ASIC1, ASIC2, TRPV1 and TRPV4 in skin tumors might be involved in tumor progression, thus being potential diagnostic and …
Some NCN show a decreasing ASIC1/2 expression in deeper dermal tumor tissue, while MM seem to not lose ASIC1/2 in deeper derma …
Segmental Upregulation of ASIC1 Channels in the Formalin Acute Pain Mouse Model.
Gobetto MN, Castellanos LCS, Contreras NE, Sodero AO, Cambiagno DA, Malnati GOM, Montes MM, Uchitel OD, Weissmann C. Gobetto MN, et al. Pharmaceuticals (Basel). 2022 Dec 12;15(12):1539. doi: 10.3390/ph15121539. Pharmaceuticals (Basel). 2022. PMID: 36558990 Free PMC article.
Behavioral tests were conducted and tissue was extracted to detect proteins (ASIC1 and pERK) and ASIC1-mRNA and mir485-5p levels. RESULTS: The injection of formalin was accompanied by an increase in ASIC1 levels. ...Gender differences were detected at the ACC …
Behavioral tests were conducted and tissue was extracted to detect proteins (ASIC1 and pERK) and ASIC1-mRNA and mir485-5p leve …
PICK1/calcineurin suppress ASIC1-mediated Ca2+ entry in rat pulmonary arterial smooth muscle cells.
Herbert LM, Nitta CH, Yellowhair TR, Browning C, Gonzalez Bosc LV, Resta TC, Jernigan NL. Herbert LM, et al. Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C390-400. doi: 10.1152/ajpcell.00091.2015. Epub 2015 Dec 23. Am J Physiol Cell Physiol. 2016. PMID: 26702130 Free PMC article.
Acid-sensing ion channel 1 (ASIC1) contributes to Ca(2+) influx and contraction in pulmonary arterial smooth muscle cells (PASMC). ASIC1 binds the PDZ (PSD-95/Dlg/ZO-1) domain of the protein interacting with C kinase 1 (PICK1), and this interaction is important for …
Acid-sensing ion channel 1 (ASIC1) contributes to Ca(2+) influx and contraction in pulmonary arterial smooth muscle cells (PASMC). …
Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension.
Nitta CH, Osmond DA, Herbert LM, Beasley BF, Resta TC, Walker BR, Jernigan NL. Nitta CH, et al. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H41-52. doi: 10.1152/ajpheart.00269.2013. Epub 2013 Nov 1. Am J Physiol Heart Circ Physiol. 2014. PMID: 24186095 Free PMC article.
To test this hypothesis, we examined responses to acute hypoxia in isolated lungs and assessed the effects of CH on indexes of PH, arterial remodeling, and vasoconstrictor reactivity in wild-type (ASIC1(+/+)) and ASIC1 knockout (ASIC1(-/-)) mice. Restoration …
To test this hypothesis, we examined responses to acute hypoxia in isolated lungs and assessed the effects of CH on indexes of PH, arterial …
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C. Ding J, et al. Aging (Albany NY). 2021 Apr 6;13(7):10703-10723. doi: 10.18632/aging.202850. Epub 2021 Apr 6. Aging (Albany NY). 2021. PMID: 33824228 Free PMC article.
Acid-sensing ion channels (ASICs) which act as key receptors for extracellular protons in central and peripheral neurons, have been implicated in IVDD where degeneration is associated with reduced microenvironmental pH. Here we show that ASIC1 and ASIC3, but not ASIC2 and …
Acid-sensing ion channels (ASICs) which act as key receptors for extracellular protons in central and peripheral neurons, have been implicat …
Upregulation of spinal ASIC1 by miR-485 mediates enterodynia in adult offspring rats with prenatal maternal stress.
Xu X, Li YC, Wu YY, Xu YC, Weng RX, Wang CL, Zhang PA, Zhang Y, Xu GY. Xu X, et al. CNS Neurosci Ther. 2021 Feb;27(2):244-255. doi: 10.1111/cns.13542. Epub 2020 Dec 13. CNS Neurosci Ther. 2021. PMID: 33314662 Free PMC article.
MiR-485 is predicted to target the expression of ASIC1. The aim of the present study was designed to determine whether miR-485/ASIC1 signaling participates in enterodynia in the spinal dorsal horn of adult offspring rats with PMS. ...Upregulating the expression mark …
MiR-485 is predicted to target the expression of ASIC1. The aim of the present study was designed to determine whether miR-485/ASI …
ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells.
Gonzalez Bosc LV, Plomaritas DR, Herbert LM, Giermakowska W, Browning C, Jernigan NL. Gonzalez Bosc LV, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L48-58. doi: 10.1152/ajplung.00040.2016. Epub 2016 May 17. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27190058 Free PMC article.
Whether Ca(2+) influx through ASIC1 contributes to NFATc3 activation in the pulmonary vasculature is unknown. ...Using both ASIC1 knockout (ASIC1(-/-)) mice and pharmacological inhibition of ASIC1, we demonstrate that ASIC1 contributes to CH-ind …
Whether Ca(2+) influx through ASIC1 contributes to NFATc3 activation in the pulmonary vasculature is unknown. ...Using both ASIC1 …
Acid-Sensing Ion Channels Structural Aspects, Pathophysiological Importance and Experimental Mutational Data Available Across Various Species to Target Human ASIC1.
Chauhan AS, Sahoo GC, Dikhit MR, Das P. Chauhan AS, et al. Curr Drug Targets. 2019;20(1):111-121. doi: 10.2174/1389450119666180820103316. Curr Drug Targets. 2019. PMID: 30124148 Review.
The review highlights the cASIC1 (Chicken ASIC1) crystal structures, involvement in physiological environment and limitations of currently available inhibitors. In addition, it details the mutational data available to design an inhibitor against hASIC1 (Human ASIC1) …
The review highlights the cASIC1 (Chicken ASIC1) crystal structures, involvement in physiological environment and limitations of curr …
564 results